Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /Xre(antitoxin) |
| Location | 4954798..4956056 | Replicon | chromosome |
| Accession | NZ_CP082821 | ||
| Organism | Pseudomonas aeruginosa strain SCAID PLC1-2021 (16/222) | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | V6AJ34 |
| Locus tag | K8B72_RS23840 | Protein ID | WP_003086331.1 |
| Coordinates | 4954798..4955553 (-) | Length | 252 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | V6AJU7 |
| Locus tag | K8B72_RS23845 | Protein ID | WP_003086329.1 |
| Coordinates | 4955688..4956056 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K8B72_RS23830 (K8B72_23830) | 4949966..4952509 | + | 2544 | WP_003134033.1 | acyl-homoserine-lactone acylase QuiP | - |
| K8B72_RS23835 (K8B72_23835) | 4952664..4954025 | - | 1362 | WP_003134034.1 | DNA recombination protein RmuC | - |
| K8B72_RS23840 (K8B72_23840) | 4954798..4955553 | - | 756 | WP_003086331.1 | RES family NAD+ phosphorylase | Toxin |
| K8B72_RS23845 (K8B72_23845) | 4955688..4956056 | - | 369 | WP_003086329.1 | DUF2384 domain-containing protein | Antitoxin |
| K8B72_RS23850 (K8B72_23850) | 4956129..4957415 | - | 1287 | WP_003134035.1 | FAD-binding oxidoreductase | - |
| K8B72_RS23855 (K8B72_23855) | 4957471..4959060 | - | 1590 | WP_003123191.1 | aldehyde dehydrogenase family protein | - |
| K8B72_RS23860 (K8B72_23860) | 4959139..4959615 | + | 477 | WP_003134036.1 | elongation factor GreAB | - |
| K8B72_RS23865 (K8B72_23865) | 4959618..4959893 | - | 276 | WP_023088486.1 | zinc ribbon domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 252 a.a. Molecular weight: 28236.34 Da Isoelectric Point: 7.7294
>T215205 WP_003086331.1 NZ_CP082821:c4955553-4954798 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA
Download Length: 756 bp
>T215205 NZ_CP110533:c2812229-2812126 [Enterobacter quasiroggenkampii]
GGCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT
GGCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT
Antitoxin
Download Length: 123 a.a. Molecular weight: 13367.63 Da Isoelectric Point: 9.9874
>AT215205 WP_003086329.1 NZ_CP082821:c4956056-4955688 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV
Download Length: 369 bp
>AT215205 NZ_CP110533:2812121-2812264 [Enterobacter quasiroggenkampii]
CAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTT
GGCATTAATGCAGGCTAAGTCGCCTTGCCTTTTAAGAATAGATGACGACGCCAGGTTTTCCAGT
CAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTT
GGCATTAATGCAGGCTAAGTCGCCTTGCCTTTTAAGAATAGATGACGACGCCAGGTTTTCCAGT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|