215201

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 151160..151665 Replicon chromosome
Accession NZ_CP082821
Organism Pseudomonas aeruginosa strain SCAID PLC1-2021 (16/222)

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag K8B72_RS00685 Protein ID WP_003083773.1
Coordinates 151160..151441 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag K8B72_RS00690 Protein ID WP_003083775.1
Coordinates 151438..151665 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8B72_RS00660 (K8B72_00660) 146411..147760 + 1350 WP_003119513.1 C4-dicarboxylate transporter DctA -
K8B72_RS00665 (K8B72_00665) 147809..148495 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
K8B72_RS00670 (K8B72_00670) 148596..149330 + 735 WP_003128333.1 GntR family transcriptional regulator -
K8B72_RS00675 (K8B72_00675) 149510..149920 + 411 WP_003110659.1 aegerolysin family protein -
K8B72_RS00680 (K8B72_00680) 149952..150860 - 909 WP_003083769.1 LysR family transcriptional regulator -
K8B72_RS00685 (K8B72_00685) 151160..151441 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
K8B72_RS00690 (K8B72_00690) 151438..151665 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
K8B72_RS00695 (K8B72_00695) 151841..152461 - 621 WP_003101226.1 hypothetical protein -
K8B72_RS00700 (K8B72_00700) 152562..153062 + 501 WP_003128336.1 LEA type 2 family protein -
K8B72_RS00705 (K8B72_00705) 153135..153476 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
K8B72_RS00710 (K8B72_00710) 153558..154985 - 1428 WP_003083784.1 GABA permease -
K8B72_RS00715 (K8B72_00715) 155154..156647 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T215201 WP_003083773.1 NZ_CP082821:c151441-151160 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T215201 NZ_CP110533:c261707-261420 [Enterobacter quasiroggenkampii]
ATGCATAAATTAACACCTTACGATCCCGCCAACGCGTTGGTGGATGACGAGGAAATCGCCGTGTTTATCGCTGATGCACT
AGAAACAGGCGACTCGACATATATCGCTAAAGCCCTTGGTGTTGTCGCGCGAGCCAAAGGCATGTCGAACATTTCACAGC
AAACCGGTTTATCACGTGAGCAGCTTTATCGGTCATTCAGTGATAAAGGAAACCCAACGCTCAAAACCACGCTCGCGGTC
ATGAAAGCATTGGGTTTTGGGCTAACACTCAAACACGCCGGGGATTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT215201 WP_003083775.1 NZ_CP082821:c151665-151438 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT215201 NZ_CP110533:c262016-261714 [Enterobacter quasiroggenkampii]
ATGAAGGAGATTGTTCAGACAGAATCCTTCCGACGCTGGGAGCAAAACTTAAAAGATCGACGAGCGAAGACCATTATCGC
TTCCCGCCTCTTTCGGTTGGCAAATGGCTTAGCGGGCGACGTTAAACCCGTGGGAGAAGGTATAAGTGAGCTAAGGATCC
ACTTTGGTCCGGGCTACAGAATCTATTTTAAAGACCAGGGCAATTGCATCATCGTGCTGTTATGTGGTGGTGACAAAAGC
AGCCAGGCCAGAGACATACTGATGGCAAAAATGCTGAGCAATGTATCCCAATGGCAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References