Detailed information of TA system TA215198

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta-couple_hipB
• Location: 1130701..1131953
• Replicon: chromosome
• Accession: NZ_CP082820
• Organism: Streptococcus pneumoniae strain SCAID PHRX1-2021

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: A0A4J2GTV6
• Locus tag: K8B76_RS05500
• Protein ID: WP_000405373.1
• Coordinates: 1130701..1131477 (-)
• Length: 259 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: -
• Locus tag: K8B76_RS05505
• Protein ID: WP_000579602.1
• Coordinates: 1131477..1131953 (-)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K8B76_RS05485 (K8B76_05485)	1125907..1126803	-	897	WP_000161642.1	restriction endonuclease	-
K8B76_RS05490 (K8B76_05490)	1126828..1129851	-	3024	WP_001858282.1	DEAD/DEAH box helicase	-
K8B76_RS05495 (K8B76_05495)	1129908..1130717	-	810	WP_000413878.1	SAVED domain-containing protein	-
K8B76_RS05500 (K8B76_05500)	1130701..1131477	-	777	WP_000405373.1	type II toxin-antitoxin system toxin PezT	Toxin
K8B76_RS05505 (K8B76_05505)	1131477..1131953	-	477	WP_000579602.1	type II toxin-antitoxin system antitoxin PezA	Antitoxin
K8B76_RS05510 (K8B76_05510)	1132398..1132853	-	456	WP_000500478.1	hypothetical protein	-
K8B76_RS05515 (K8B76_05515)	1133128..1134867	-	1740	Protein_1097	glycoside hydrolase family 13 protein	-
K8B76_RS05520 (K8B76_05520)	1135030..1135914	-	885	WP_000710117.1	diacylglycerol kinase family lipid kinase	-
K8B76_RS05525 (K8B76_05525)	1136026..1136880	-	855	Protein_1099	ADP-ribosylglycohydrolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1125907..1147185	21278

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (25-215)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 259 a.a.
• Molecular weight: 29509.43 Da
• Isoelectric Point: 6.9224

>T215198 WP_000405373.1 NZ_CP082820:c1131477-1130701 [Streptococcus pneumoniae]
MEIQDYTDSEFKHALARNLRSLTRGKKSSKQSIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
ENGKDSVEYTKDFAGKMVESLVTELSHLGYNLLIEGTLRTIDVPKKTAQLLKNKGYEVQLALIATKPELSYLSTLIRYEE
LYAINPNPARATPKEHHDFIVNHLVDNTRQLEELAIFERIQIYQRDRSCVYDSKENTTSAAEVLQEYLFGKWSKVEEEML
KVGEERMRDMSKSNGKDA

Nucleotide

• Length: 777 bp

>T215198 NZ_CP110532:c2848266-2848163 [Enterobacter roggenkampii]
GGCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18289.70 Da
• Isoelectric Point: 4.4188

>AT215198 WP_000579602.1 NZ_CP082820:c1131953-1131477 [Streptococcus pneumoniae]
MIGKNIKSLRKTHDLTQHEFARIIGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIQTNIYLVENFDEIERYSGYLDGIERMLEISEKRMVA

Nucleotide

• Length: 477 bp

>AT215198 NZ_CP110532:2848158-2848301 [Enterobacter roggenkampii]
CAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTT
GGCATTAATGCAGGCTAAGTCGCCTTGCCTTTTAAGAATAGATGACGACGCCAGGTTTTCCAGT

Structures

Toxin

• AlphaFold DB: A0A4J2GTV6