Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2231744..2232258 Replicon chromosome
Accession NZ_CP082815
Organism Staphylococcus aureus strain SCAID WND1-2021 (598)

Toxin (Protein)


Gene name TsdT Uniprot ID A0A7U7IDH9
Locus tag K8B78_RS11105 Protein ID WP_000581791.1
Coordinates 2231744..2231953 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag K8B78_RS11110 Protein ID WP_000138934.1
Coordinates 2231965..2232258 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8B78_RS11085 (2227662) 2227662..2228732 - 1071 WP_000159639.1 D-alanine--D-alanine ligase -
K8B78_RS11090 (2229050) 2229050..2230252 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
K8B78_RS11095 (2230413) 2230413..2231096 - 684 Protein_2162 transposase -
K8B78_RS11100 (2231479) 2231479..2231616 - 138 WP_000828354.1 Lmo0850 family protein -
K8B78_RS11105 (2231744) 2231744..2231953 - 210 WP_000581791.1 heavy metal-associated domain-containing protein Toxin
K8B78_RS11110 (2231965) 2231965..2232258 - 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
K8B78_RS11115 (2232424) 2232424..2233908 + 1485 WP_223065130.1 cardiolipin synthase -
K8B78_RS11120 (2233936) 2233936..2234583 + 648 WP_001187612.1 HD domain-containing protein -
K8B78_RS11125 (2235196) 2235196..2236068 - 873 WP_000725802.1 membrane protein insertase YidC -
K8B78_RS11130 (2236154) 2236154..2236795 - 642 WP_000483150.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7826.83 Da        Isoelectric Point: 4.1008

>T215191 WP_000581791.1 NZ_CP082815:c2231953-2231744 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVIINIIDGQVTVAYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T215191 NZ_CP110528:258-608 [Klebsiella pneumoniae]
ATGTGGGATATCATAACAACCGAGTGCTTTGATGGGTGGTTTCTTGCTCAGAGCGATGCTCTCAGGGAGTCTGTCTATGA
GGCTATGGGTGTACTGGAGAAATTCGGCCCGGCACTAGGTAGACCGTATGTTGATACGCTAAACGATTCTGATTTTGCCA
ATATGAAAGAGTTGCGCATCCAACATCATGGTAATCCTGTCAGAGCATTTTTTGCGTTTGATCCTACGCGCCGCGCCATC
GTCTTGTGTGCCGGTGATAAAACAGGGGCAAACGAAAAGCGCTTCTATAAGGATATGATTAGGCTTGCTGATTCGGAATA
CCGTAAACATCTTGCGAAACTGGAGAAATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT215191 WP_000138934.1 NZ_CP082815:c2232258-2231965 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT215191 NZ_CP110528:611-910 [Klebsiella pneumoniae]
ATGGCTACTTACAGAGAACTCCTGGCTAAAGAAAGCCCTGAAATGCAGGCTAGGGTAGCGGAGCGGGTTGAAGAAGTCAG
CATTCAAATAGCTCTTAGCATGTTACGTGATGAGCTAAATATTTCACAAACTGAGCTGGCTGCTGTCATGGGTGTTAAAC
AACCTTCTGTTGCCCGTATGGAGCAGGCTGACAATGATCCGAGACTATCAACACTCAAACGTTACGTGAAAGCGTTAGGT
GGAGAATTGAGTTTGGATGTAACACTTCCGACTGGTAAGCGAGTTGCATTTCATATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7IDH9

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References