Detailed information of TA system TA215170

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1841795..1842571
• Replicon: chromosome
• Accession: NZ_CP082813
• Organism: Staphylococcus aureus strain SCAID OTT1-2021 (597/2)

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: K8B68_RS08745
• Protein ID: WP_000031109.1
• Coordinates: 1841795..1841947 (-)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: W8U4V4
• Locus tag: K8B68_RS08750
• Protein ID: WP_001251224.1
• Coordinates: 1841972..1842571 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K8B68_RS08730 (1837714)	1837714..1838535	+	822	WP_000669377.1	RluA family pseudouridine synthase	-
K8B68_RS08735 (1838992)	1838992..1840377	-	1386	WP_000116239.1	class II fumarate hydratase	-
K8B68_RS08740 (1840573)	1840573..1840968	-	396	WP_000901019.1	hypothetical protein	-
K8B68_RS08745 (1841795)	1841795..1841947	-	153	WP_000031109.1	SAS053 family protein	Toxin
K8B68_RS08750 (1841972)	1841972..1842571	-	600	WP_001251224.1	glucosamine-6-phosphate isomerase	Antitoxin
K8B68_RS08755 (1842730)	1842730..1843200	-	471	WP_000181394.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
K8B68_RS08760 (1843205)	1843205..1844332	-	1128	WP_000379990.1	tRNA epoxyqueuosine(34) reductase QueG	-
K8B68_RS08765 (1844483)	1844483..1845205	-	723	WP_000590809.1	amino acid ABC transporter ATP-binding protein	-
K8B68_RS08770 (1845198)	1845198..1846655	-	1458	WP_000649916.1	ABC transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5950.31 Da
• Isoelectric Point: 3.9075

>T215170 WP_000031109.1 NZ_CP082813:c1841947-1841795 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEESQ

Nucleotide

• Length: 153 bp

>T215170 NZ_CP110523:755597-756082 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGACCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22343.47 Da
• Isoelectric Point: 5.1445

>AT215170 WP_001251224.1 NZ_CP082813:c1842571-1841972 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT215170 NZ_CP110523:755307-755600 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA

Structures

Antitoxin

• AlphaFold DB: W8U4V4