Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-MazE
Location 13994..14589 Replicon plasmid unnamed2
Accession NZ_CP082811
Organism Burkholderia contaminans strain SCAID TST1-2021 (11/270)

Toxin (Protein)


Gene name chpB Uniprot ID A0A6P2RVL2
Locus tag K8B66_RS37690 Protein ID WP_039341512.1
Coordinates 13994..14344 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID -
Locus tag K8B66_RS37695 Protein ID WP_076841588.1
Coordinates 14338..14589 (-) Length 84 a.a.

Genomic Context

K8B66_RS37645K8B66_RS37650K8B66_RS38750K8B66_RS37655K8B66_RS38460K8B66_RS37660K8B66_RS37665K8B66_RS37670K8B66_RS37675K8B66_RS37680K8B66_RS37685K8B66_RS37690K8B66_RS37695K8B66_RS37700K8B66_RS37705K8B66_RS37710K8B66_RS38465K8B66_RS38470
Location: 9603..10151 (549 bp)
Type: Others
Protein ID: WP_039341499.1
Location: 10164..10628 (465 bp)
Type: Others
Protein ID: WP_039341501.1
Location: 10732..10854 (123 bp)
Type: Others
Protein ID: WP_256103105.1
Location: 10906..11319 (414 bp)
Type: Others
Protein ID: WP_069586059.1
Location: 11469..11699 (231 bp)
Type: Others
Protein ID: WP_083268473.1
Location: 11708..12058 (351 bp)
Type: Others
Protein ID: WP_046196913.1
Location: 12141..12365 (225 bp)
Type: Others
Protein ID: WP_039341503.1
Location: 12410..13084 (675 bp)
Type: Others
Protein ID: WP_076841591.1
Location: 13156..13365 (210 bp)
Type: Others
Protein ID: WP_039341506.1
Location: 13337..13690 (354 bp)
Type: Others
Protein ID: WP_157644981.1
Location: 13739..13981 (243 bp)
Type: Others
Protein ID: WP_039341511.1
Location: 13994..14344 (351 bp)
Type: Toxin
Protein ID: WP_039341512.1
Location: 14338..14589 (252 bp)
Type: Antitoxin
Protein ID: WP_076841588.1
Location: 14795..16276 (1482 bp)
Type: Others
Protein ID: WP_069586063.1
Location: 16309..16449 (141 bp)
Type: Others
Protein ID: WP_157644980.1
Location: 16453..17568 (1116 bp)
Type: Others
Protein ID: WP_069586064.1
Location: 17565..18248 (684 bp)
Type: Others
Protein ID: WP_225936036.1
Location: 18378..19046 (669 bp)
Type: Others
Protein ID: Protein_31
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
K8B66_RS37645 (K8B66_37645)9603..10151-549WP_039341499.1phospholipase D family protein-
K8B66_RS37650 (K8B66_37650)10164..10628-465WP_039341501.1hypothetical protein-
K8B66_RS3875010732..10854-123WP_256103105.1hypothetical protein-
K8B66_RS37655 (K8B66_37655)10906..11319-414WP_069586059.1hypothetical protein-
K8B66_RS3846011469..11699-231WP_083268473.1hypothetical protein-
K8B66_RS37660 (K8B66_37660)11708..12058-351WP_046196913.1hypothetical protein-
K8B66_RS37665 (K8B66_37665)12141..12365-225WP_039341503.1hypothetical protein-
K8B66_RS37670 (K8B66_37670)12410..13084-675WP_076841591.1hypothetical protein-
K8B66_RS37675 (K8B66_37675)13156..13365-210WP_039341506.1hypothetical protein-
K8B66_RS37680 (K8B66_37680)13337..13690-354WP_157644981.1hypothetical protein-
K8B66_RS37685 (K8B66_37685)13739..13981-243WP_039341511.1hypothetical protein-
K8B66_RS37690 (K8B66_37690)13994..14344-351WP_039341512.1type II toxin-antitoxin system ChpB family toxinToxin
K8B66_RS37695 (K8B66_37695)14338..14589-252WP_076841588.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
K8B66_RS37700 (K8B66_37700)14795..16276-1482WP_069586063.1hypothetical protein-
K8B66_RS37705 (K8B66_37705)16309..16449-141WP_157644980.1hypothetical protein-
K8B66_RS37710 (K8B66_37710)16453..17568-1116WP_069586064.1P-type DNA transfer ATPase VirB11-
K8B66_RS3846517565..18248-684WP_225936036.1TrbI/VirB10 family protein-
K8B66_RS3847018378..19046-669Protein_31IS21 family transposase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid--1..2741727417


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-116)

Antitoxin

Antitoxin PemI-like

(1-83)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12400.34 Da        Isoelectric Point: 8.6851

>T215168 WP_039341512.1 NZ_CP082811:c14344-13994 [Burkholderia contaminans]
MVRRVKFERGDIVRVSLNPTIGKEQQGDFRPALVLSPAAFNALGVALVAPITQGGEFARYAGFAVPLSGAGTETQGVALV
NMVRTLDLEARGARKVERAPVEVVEDALARLQTILE

Download         Length: 351 bp

>T215168 NZ_CP110523:349494-349862 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATGTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 8904.14 Da        Isoelectric Point: 4.9679

>AT215168 WP_076841588.1 NZ_CP082811:c14589-14338 [Burkholderia contaminans]
MELKIQKWGNSAAVRLPAVLLEQIGASAGSSLNADVRPDGVLLTPARRKYSLDELVAQCDQNAPQPADLAAWVEAKPVGH
EAW

Download         Length: 252 bp

>AT215168 NZ_CP110523:349276-349497 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A6P2RVL2

Antitoxin

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Source
ID
Structure
No matching records found

References