Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 2861406..2861925 Replicon chromosome
Accession NZ_CP082808
Organism Burkholderia contaminans strain SCAID TST1-2021 (11/270)

Toxin (Protein)


Gene name relE Uniprot ID A0A1E3FLI5
Locus tag K8B66_RS30120 Protein ID WP_039349649.1
Coordinates 2861406..2861687 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A4V2WFY1
Locus tag K8B66_RS30125 Protein ID WP_039349647.1
Coordinates 2861677..2861925 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8B66_RS30100 (K8B66_30100) 2857061..2857759 - 699 WP_039349658.1 MgtC/SapB family protein -
K8B66_RS30105 (K8B66_30105) 2857874..2858983 + 1110 WP_039349656.1 AGE family epimerase/isomerase -
K8B66_RS30110 (K8B66_30110) 2858956..2860575 - 1620 WP_039349654.1 methyl-accepting chemotaxis protein -
K8B66_RS30115 (K8B66_30115) 2860845..2861288 + 444 WP_011353771.1 PaaI family thioesterase -
K8B66_RS30120 (K8B66_30120) 2861406..2861687 - 282 WP_039349649.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K8B66_RS30125 (K8B66_30125) 2861677..2861925 - 249 WP_039349647.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
K8B66_RS30130 (K8B66_30130) 2862067..2863119 - 1053 WP_039349645.1 CaiB/BaiF CoA-transferase family protein -
K8B66_RS30135 (K8B66_30135) 2863303..2864493 - 1191 WP_039349643.1 2-methylaconitate cis-trans isomerase PrpF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-81)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(12-78)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10986.88 Da        Isoelectric Point: 10.7091

>T215166 WP_039349649.1 NZ_CP082808:c2861687-2861406 [Burkholderia contaminans]
MTFELAFLEPALKEWKKLDRTVRDQFKSRLAERLENPRIPSAKLQGHPDRYKIKLRSVGYRLVYEVRDSEVLVLVVAVGR
RERDAVYLAAMKR

Download         Length: 282 bp

>T215166 NZ_CP110518:c14266-13916 [Klebsiella pneumoniae]
ATGTGGGTCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACCGATAGAGCAAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGCCCCATGCTGTCGAGGCCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTTCGGGTCCAAAGCAAAGGAGATCCTATCAGAGCGTTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGTGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9031.44 Da        Isoelectric Point: 5.6792

>AT215166 WP_039349647.1 NZ_CP082808:c2861925-2861677 [Burkholderia contaminans]
MPHTILANVTASVSELKRNPMGTVAAGEGFPVAILNHNEPAFYCIPAKTWEAMVERLEDIEDNALADKRAKEKVVKVKLN
DL

Download         Length: 249 bp

>AT215166 NZ_CP110518:c13911-13609 [Klebsiella pneumoniae]
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1E3FLI5

Antitoxin

Source ID Structure
AlphaFold DB A0A4V2WFY1

References