Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1860720..1862470 Replicon chromosome
Accession NZ_CP082808
Organism Burkholderia contaminans strain SCAID TST1-2021 (11/270)

Toxin (Protein)


Gene name doc Uniprot ID A0A1E3FSX8
Locus tag K8B66_RS25715 Protein ID WP_039344096.1
Coordinates 1861574..1862470 (-) Length 299 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A1E3FSY5
Locus tag K8B66_RS25710 Protein ID WP_039344097.1
Coordinates 1860720..1861577 (-) Length 286 a.a.

Genomic Context

K8B66_RS25745K8B66_RS25690K8B66_RS25695K8B66_RS25700K8B66_RS25705K8B66_RS25710K8B66_RS25715K8B66_RS25720K8B66_RS25725K8B66_RS25730K8B66_RS25735K8B66_RS25740
Location: 1866021..1867100 (1080 bp)
Type: Others
Protein ID: WP_039344086.1
Location: 1855883..1857373 (1491 bp)
Type: Others
Protein ID: WP_039344105.1
Location: 1857446..1858273 (828 bp)
Type: Others
Protein ID: WP_039344103.1
Location: 1858266..1859933 (1668 bp)
Type: Others
Protein ID: WP_039344101.1
Location: 1859926..1860723 (798 bp)
Type: Others
Protein ID: WP_039344099.1
Location: 1860720..1861577 (858 bp)
Type: Antitoxin
Protein ID: WP_039344097.1
Location: 1861574..1862470 (897 bp)
Type: Toxin
Protein ID: WP_039344096.1
Location: 1862489..1863016 (528 bp)
Type: Others
Protein ID: WP_039344094.1
Location: 1863054..1863824 (771 bp)
Type: Others
Protein ID: WP_039344092.1
Location: 1863817..1864893 (1077 bp)
Type: Others
Protein ID: WP_039344090.1
Location: 1864946..1865257 (312 bp)
Type: Others
Protein ID: WP_039344088.1
Location: 1865259..1865576 (318 bp)
Type: Others
Protein ID: WP_011354710.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
K8B66_RS25690 (K8B66_25690)1855883..1857373-1491WP_039344105.1aldehyde dehydrogenase-
K8B66_RS25695 (K8B66_25695)1857446..1858273-828WP_039344103.1aspartate dehydrogenase-
K8B66_RS25700 (K8B66_25700)1858266..1859933-1668WP_039344101.1thiamine pyrophosphate-binding protein-
K8B66_RS25705 (K8B66_25705)1859926..1860723-798WP_039344099.1SDR family oxidoreductase-
K8B66_RS25710 (K8B66_25710)1860720..1861577-858WP_039344097.1IclR family transcriptional regulatorAntitoxin
K8B66_RS25715 (K8B66_25715)1861574..1862470-897WP_039344096.1alpha/beta fold hydrolaseToxin
K8B66_RS25720 (K8B66_25720)1862489..1863016-528WP_039344094.1cupin domain-containing protein-
K8B66_RS25725 (K8B66_25725)1863054..1863824-771WP_039344092.1SDR family oxidoreductase-
K8B66_RS25730 (K8B66_25730)1863817..1864893-1077WP_039344090.1aromatic ring-hydroxylating dioxygenase subunit alpha-
K8B66_RS25735 (K8B66_25735)1864946..1865257-312WP_039344088.1hypothetical protein-
K8B66_RS25740 (K8B66_25740)1865259..1865576-318WP_011354710.1non-heme iron oxygenase ferredoxin subunit-
K8B66_RS25745 (K8B66_25745)1866021..1867100+1080WP_039344086.1porin-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(51-279)

Antitoxin

Transcription regulator IclR, C-terminal

(143-266)


Sequences

Toxin        


Download         Length: 299 a.a.        Molecular weight: 30700.99 Da        Isoelectric Point: 8.0624

>T215165 WP_039344096.1 NZ_CP082808:c1862470-1861574 [Burkholderia contaminans]
MSVIDKRERDRTAAFAALLGQFPEQRCAAGAAGTIGYREAGAHHAGRALPVVLLHGIGSGAASWVRQLDTLGASRRVLAW
DAPGYGVSTPVHGASPAATDYAASLNAWLEALGIERCVLVGHSLGAIIAGGLIRVMPARIAGLLLVSPAGGYGSAPAETR
DARRDARLAMLAELGPAGLAEQRSGNMLSGFANEDARAWVRWNMARIVPAGYAQATQLLANADLATDLAGFRGRTAVAVG
ANDAITPPAACERIAAAAHVGLQVIPQAGHAGYVEAPAVYSALIDAFCRQCDQQRGLA

Download         Length: 897 bp

>T215165 NZ_CP110517:c63892-63515 [Klebsiella pneumoniae]
ATGCAAACACAACCTGTTCCTCCGAAACGGGAGGTTTCGCCACGCCCGTCACCCGTGGCGATCTGGCAGCGCCTCCTGAG
TCACCTGCTGGACCGTCACTACGGTCTGACGCTCAACGACACGCCATTTGGCAAAGATGGTGTGATCCAAGAGCATATCG
ATGCCGGTATCTCACTGTGCGACGCGGTGAATTTCATCGTGGAGAAATACGACCTGGTACGCACTGATCGTCGCGGTTTT
AACGCGGAAACTCAGTCGCCGCTTCTCACCAGTATCGATATTCTCCGCGCCCGCAAAGCCACCGGGCTGATGACCCGTCA
TAGCTACAGGGCCGTTACCGACATCACCACCGGCAAATACCGTGAGGTGCAACCATGA

Antitoxin


Download         Length: 286 a.a.        Molecular weight: 31463.03 Da        Isoelectric Point: 6.7661

>AT215165 WP_039344097.1 NZ_CP082808:c1861577-1860720 [Burkholderia contaminans]
MNEPLQRPELENGKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYK
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQAPVFSSIRVNVGTRLPAHATTHGH
VLMGDLSLKELHALYPEGTLNRMTNATPETVDALYEVIREDALRGYGVSNSSFERGISVVTAPVRNETQRIVACITVTVP
RPEIDAALIADGLIDKVQRAAAELSRRLNYRSDDEHTFLKALGLR

Download         Length: 858 bp

>AT215165 NZ_CP110517:c64301-63942 [Klebsiella pneumoniae]
TTGTCGAATACAATACCGCCTGTAAACCACGATATCGCCGCCCCTTGGTGGGGGCTTAAACGCGATATCACCCCCTGTTT
TGGCGCACGTCTGGTGCAGGAGGGCAACCGGCTGCATTACCTGAACGACCGCGCCAGCATCACCGGCACCTTCAGCGACG
CGGATTTACGCCATCTCGACCAGGCATTCCCGCTACTGCTGAAGCAACTGGAGCTGATGCTGCTTTCCGGTGAGCTGAAT
CCCCGTCATCAGCACTGCGTCACGCTGTATGCAAAAGGGCTGATATGCGAGGCCGACAGCCTCGGCTCGCACGGGTACGT
CTATCTCGCAATTTACCCGACACCTGCAACAACAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A1E3FSX8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1E3FSY5

References