Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-vagC/VapC-VagC
Location 178358..178995 Replicon chromosome
Accession NZ_CP082807
Organism Burkholderia contaminans strain SCAID TST1-2021 (11/270)

Toxin (Protein)


Gene name vapC Uniprot ID A0A228K4S8
Locus tag K8B66_RS00730 Protein ID WP_039351354.1
Coordinates 178594..178995 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A1E3FXY0
Locus tag K8B66_RS00725 Protein ID WP_039351357.1
Coordinates 178358..178594 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8B66_RS00710 (K8B66_00710) 174051..175082 + 1032 WP_039351365.1 helix-turn-helix domain-containing protein -
K8B66_RS00715 (K8B66_00715) 175200..176297 - 1098 WP_039351363.1 ADP-heptose--LPS heptosyltransferase -
K8B66_RS00720 (K8B66_00720) 176294..177997 - 1704 WP_039351360.1 thiamine pyrophosphate-binding protein -
K8B66_RS00725 (K8B66_00725) 178358..178594 + 237 WP_039351357.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
K8B66_RS00730 (K8B66_00730) 178594..178995 + 402 WP_039351354.1 type II toxin-antitoxin system VapC family toxin Toxin
K8B66_RS00735 (K8B66_00735) 179066..180454 - 1389 WP_039351351.1 L-serine ammonia-lyase -
K8B66_RS00740 (K8B66_00740) 180485..181588 - 1104 WP_223274380.1 alginate lyase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14880.98 Da        Isoelectric Point: 4.7249

>T215160 WP_039351354.1 NZ_CP082807:178594-178995 [Burkholderia contaminans]
MPRYMLDTNMCIYLMKNQPEQVARRFAQCYTGDVVMSAITYAELEYGVAACASPARERGNLAALIDDIPVAPFDVAAAQA
YGPVREATRERKKDHLDKLIAAHAVSLDVVLVTNNERDFVSYPGLRLENWLDD

Download         Length: 402 bp

>T215160 NZ_CP110515:190047-190331 [Klebsiella pneumoniae]
ATGACCTATAAGCTGGCTTTCAACGAATCCGCTCTGAAAGAATGGAAGAAGCTGGGTCATACACTACAGGTACAGTTCAA
AAAGAAACTCAAAGAGCGCCTGGAGAACCCCAGAGTTCCGGCATCACAGCTACATGGACGTAAGGACCAGTATAAAATTA
AGCTACGTGGTGCCGGATATCGCCTTGTCTATCGTGTAGAGGACGACATTGTCACAGTCACTGTTATCGGCGTAGGCAAA
CGCGAAAACGACGACATTTATAATGCAACCCTTAATCGCAATTGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9008.13 Da        Isoelectric Point: 6.4720

>AT215160 WP_039351357.1 NZ_CP082807:178358-178594 [Burkholderia contaminans]
MHTTRVFRNGNSQAVRIPADLAYERSDIELEIERIGDEIRIRPARRPLTRVLEKFAKFGPDFMADGRGDHEQADREGL

Download         Length: 237 bp

>AT215160 NZ_CP110515:189809-190057 [Klebsiella pneumoniae]
ATGGCATTTCAGGTTCTGACCACTACAGCAGCTAGCATTACTGAACTTAAACGTGACCCTATGGGTACTTTCCACGCCGG
GGATGGCGCTCCGGTAGCCATTCTTAATCGTAATGAGCCTGCATTCTACTGTGTGCCACCGGCACTCTATGCCCAGTTGA
TGGAGCTTCTGGAAGATGAAGAGCTGGGACGGATGGCTGATGAGCGAAGCGGAGAAAAGGTTATAGAGGTCAATATTGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A228K4S8

Antitoxin

Source ID Structure
AlphaFold DB A0A1E3FXY0

References