Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 799215..799872 Replicon chromosome
Accession NZ_CP082805
Organism Klebsiella pneumoniae strain SCAID PHRX1-2021 (13/97)

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag K8B74_RS03965 Protein ID WP_002916310.1
Coordinates 799462..799872 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag K8B74_RS03960 Protein ID WP_002916312.1
Coordinates 799215..799481 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8B74_RS03935 (794423) 794423..795856 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
K8B74_RS03940 (795975) 795975..796703 - 729 WP_048336809.1 MurR/RpiR family transcriptional regulator -
K8B74_RS03945 (796753) 796753..797064 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
K8B74_RS03950 (797228) 797228..797887 + 660 WP_002916317.1 hemolysin III family protein -
K8B74_RS03955 (797986) 797986..798969 - 984 WP_014906951.1 tRNA-modifying protein YgfZ -
K8B74_RS03960 (799215) 799215..799481 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
K8B74_RS03965 (799462) 799462..799872 + 411 WP_002916310.1 protein YgfX Toxin
K8B74_RS03970 (799879) 799879..800400 - 522 WP_002916308.1 flavodoxin FldB -
K8B74_RS03975 (800501) 800501..801397 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
K8B74_RS03980 (801420) 801420..802133 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
K8B74_RS03985 (802139) 802139..803872 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T215144 WP_002916310.1 NZ_CP082805:799462-799872 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T215144 NZ_CP110514:349494-349862 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATGTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT215144 WP_002916312.1 NZ_CP082805:799215-799481 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT215144 NZ_CP110514:349276-349497 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References