Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 793678..794335 Replicon chromosome
Accession NZ_CP082799
Organism Klebsiella pneumoniae strain SCAID TST1-2021 (15/226)

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag K8B70_RS03965 Protein ID WP_002916310.1
Coordinates 793925..794335 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag K8B70_RS03960 Protein ID WP_002916312.1
Coordinates 793678..793944 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8B70_RS03935 (789320) 789320..790048 - 729 WP_117065205.1 MurR/RpiR family transcriptional regulator -
K8B70_RS03940 (790120) 790120..791088 - 969 WP_013815099.1 IS5-like element IS903B family transposase -
K8B70_RS03945 (791164) 791164..791475 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
K8B70_RS03950 (791639) 791639..792298 + 660 WP_002916317.1 hemolysin III family protein -
K8B70_RS03955 (792449) 792449..793432 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
K8B70_RS03960 (793678) 793678..793944 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
K8B70_RS03965 (793925) 793925..794335 + 411 WP_002916310.1 protein YgfX Toxin
K8B70_RS03970 (794342) 794342..794863 - 522 WP_004144730.1 flavodoxin FldB -
K8B70_RS03975 (794964) 794964..795860 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
K8B70_RS03980 (795883) 795883..796596 + 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
K8B70_RS03985 (796602) 796602..798335 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 790120..791043 923


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T215123 WP_002916310.1 NZ_CP082799:793925-794335 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T215123 NZ_CP110511:304815-304918 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT215123 WP_002916312.1 NZ_CP082799:793678-793944 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT215123 NZ_CP110511:c304956-304685 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References