Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /RES-TIGR02293 |
| Location | 99597..100507 | Replicon | plasmid unnamed1 |
| Accession | NZ_CP082797 | ||
| Organism | Klebsiella pneumoniae strain SCAID PHRX2-2021 (20/245) | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | R4YBC5 |
| Locus tag | K8B77_RS25925 | Protein ID | WP_004144067.1 |
| Coordinates | 100037..100507 (+) | Length | 157 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | W9B1L8 |
| Locus tag | K8B77_RS25920 | Protein ID | WP_016528982.1 |
| Coordinates | 99597..100040 (+) | Length | 148 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K8B77_RS25890 (K8B77_25890) | 94611..95132 | + | 522 | WP_004213635.1 | ferric citrate uptake sigma factor FecI | - |
| K8B77_RS25895 (K8B77_25895) | 95129..96082 | + | 954 | Protein_95 | fec operon regulator FecR | - |
| K8B77_RS25900 (K8B77_25900) | 96169..98295 | + | 2127 | WP_032446634.1 | TonB-dependent Fe(3+) dicitrate receptor FecA | - |
| K8B77_RS25905 (K8B77_25905) | 98377..98496 | + | 120 | Protein_97 | Fe3+-citrate ABC transporter substrate-binding protein | - |
| K8B77_RS25910 (K8B77_25910) | 98677..98898 | + | 222 | WP_016528984.1 | DUF2188 domain-containing protein | - |
| K8B77_RS25915 (K8B77_25915) | 99007..99496 | + | 490 | Protein_99 | DUF4113 domain-containing protein | - |
| K8B77_RS25920 (K8B77_25920) | 99597..100040 | + | 444 | WP_016528982.1 | DUF2384 domain-containing protein | Antitoxin |
| K8B77_RS25925 (K8B77_25925) | 100037..100507 | + | 471 | WP_004144067.1 | RES family NAD+ phosphorylase | Toxin |
| K8B77_RS25930 (K8B77_25930) | 100618..100878 | - | 261 | WP_016528980.1 | hypothetical protein | - |
| K8B77_RS25935 (K8B77_25935) | 101278..102506 | + | 1229 | WP_085956323.1 | IS3 family transposase | - |
| K8B77_RS25940 (K8B77_25940) | 102477..103256 | - | 780 | WP_225932725.1 | Hok/Gef family protein | - |
| K8B77_RS25945 (K8B77_25945) | 103742..103909 | + | 168 | WP_162837823.1 | hypothetical protein | - |
| K8B77_RS27030 (K8B77_25950) | 104550..104708 | - | 159 | WP_004181898.1 | type I toxin-antitoxin system Hok family toxin | - |
| K8B77_RS25955 (K8B77_25955) | 105193..105399 | + | 207 | Protein_107 | IS66 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | iucA / iucB / iucC / iucD / iutA / iroB / iroC / iroD / iroN / rmpA | 1..162135 | 162135 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 157 a.a. Molecular weight: 17573.83 Da Isoelectric Point: 4.5152
>T215117 WP_004144067.1 NZ_CP082797:100037-100507 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPDNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPDNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
Download Length: 471 bp
>T215117 NZ_CP110473:1466698-1467030 [Pantoea anthophila]
ATGGAGAGAGGAGAAATCTGGCTGGTGACCCTCGATCCTACAGCAGGTCATGAACAAAGCGGGAGGCGTCCGGTACTTAT
CGTTTCTCCGGCTTCCTTTAACGCATTTACCCGATTACCGATTGTGGTGCCGGTGACCCGCGGCGGGAATTTTGCCCGTG
CAGCAGGCTTTGCTGTTTCACTGGATGGAGCAGGGTGCAGAACAAAGGGTGTCGTTCGCTGCGATCAGCCGAGAACGCTC
GATATGGAAGCCCGCGAAGGCAGGCGGCTTGAGAGACTTCCTGACGCTATCGTGAACGAAGTGCTGGCACGGCTGGAAGC
CATTCTGAACTGA
ATGGAGAGAGGAGAAATCTGGCTGGTGACCCTCGATCCTACAGCAGGTCATGAACAAAGCGGGAGGCGTCCGGTACTTAT
CGTTTCTCCGGCTTCCTTTAACGCATTTACCCGATTACCGATTGTGGTGCCGGTGACCCGCGGCGGGAATTTTGCCCGTG
CAGCAGGCTTTGCTGTTTCACTGGATGGAGCAGGGTGCAGAACAAAGGGTGTCGTTCGCTGCGATCAGCCGAGAACGCTC
GATATGGAAGCCCGCGAAGGCAGGCGGCTTGAGAGACTTCCTGACGCTATCGTGAACGAAGTGCTGGCACGGCTGGAAGC
CATTCTGAACTGA
Antitoxin
Download Length: 148 a.a. Molecular weight: 16494.83 Da Isoelectric Point: 10.2498
>AT215117 WP_016528982.1 NZ_CP082797:99597-100040 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEIIKLITRLEHGVYS
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEIIKLITRLEHGVYS
Download Length: 444 bp
>AT215117 NZ_CP110473:1466440-1466697 [Pantoea anthophila]
ATGTTTATCACGCGTCTTAAAAAGGTAGGCGGATCGGTCATGCTGGCGGTTCCTCCCGCCGTTCTGAAAACGCTGTCGTT
GTCGGCAAACAGTGAAGTCGGAATGACCATCGATAATGGTTATCTGATCGTCAAACCCCGGACCCGACCGCGCTATTCAC
TTGAGGAACTGCTTGCGCAATGCGATCCACATGCGGAAATCAGTAAAGAAGATCGCGACTGGATTGATGCACCTGCAGCA
GGTAAGGAGAACCTGTAA
ATGTTTATCACGCGTCTTAAAAAGGTAGGCGGATCGGTCATGCTGGCGGTTCCTCCCGCCGTTCTGAAAACGCTGTCGTT
GTCGGCAAACAGTGAAGTCGGAATGACCATCGATAATGGTTATCTGATCGTCAAACCCCGGACCCGACCGCGCTATTCAC
TTGAGGAACTGCTTGCGCAATGCGATCCACATGCGGAAATCAGTAAAGAAGATCGCGACTGGATTGATGCACCTGCAGCA
GGTAAGGAGAACCTGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A384IED8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | W9B1L8 |