Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | ataRT/DUF1778(antitoxin) |
| Location | 38704..39455 | Replicon | plasmid unnamed1 |
| Accession | NZ_CP082797 | ||
| Organism | Klebsiella pneumoniae strain SCAID PHRX2-2021 (20/245) | ||
Toxin (Protein)
| Gene name | ataT | Uniprot ID | W9BA31 |
| Locus tag | K8B77_RS25595 | Protein ID | WP_032104592.1 |
| Coordinates | 38973..39455 (+) | Length | 161 a.a. |
Antitoxin (Protein)
| Gene name | ataR | Uniprot ID | W9B1S8 |
| Locus tag | K8B77_RS25590 | Protein ID | WP_016529519.1 |
| Coordinates | 38704..38982 (+) | Length | 93 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K8B77_RS25575 (K8B77_25575) | 34923..36005 | - | 1083 | WP_016528990.1 | DNA-binding transcriptional repressor LacI | - |
| K8B77_RS26985 | 36041..36123 | - | 83 | Protein_30 | hypothetical protein | - |
| K8B77_RS25580 (K8B77_25580) | 36466..37476 | + | 1011 | WP_004152284.1 | zinc-binding alcohol dehydrogenase family protein | - |
| K8B77_RS25585 (K8B77_25585) | 37860..38396 | - | 537 | WP_032445791.1 | hypothetical protein | - |
| K8B77_RS25590 (K8B77_25590) | 38704..38982 | + | 279 | WP_016529519.1 | DUF1778 domain-containing protein | Antitoxin |
| K8B77_RS25595 (K8B77_25595) | 38973..39455 | + | 483 | WP_032104592.1 | GNAT family N-acetyltransferase | Toxin |
| K8B77_RS25600 (K8B77_25600) | 39493..39897 | + | 405 | WP_016529521.1 | DUF2251 domain-containing protein | - |
| K8B77_RS25605 (K8B77_25605) | 40234..41067 | + | 834 | WP_012540133.1 | GIY-YIG nuclease family protein | - |
| K8B77_RS25610 (K8B77_25610) | 41167..41328 | + | 162 | WP_223367960.1 | bacteriocin immunity protein | - |
| K8B77_RS25615 (K8B77_25615) | 41423..41659 | - | 237 | WP_016529523.1 | hypothetical protein | - |
| K8B77_RS25625 (K8B77_25625) | 43420..43872 | - | 453 | WP_000211298.1 | transcriptional repressor | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | iucA / iucB / iucC / iucD / iutA / iroB / iroC / iroD / iroN / rmpA | 1..162135 | 162135 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 161 a.a. Molecular weight: 17781.73 Da Isoelectric Point: 9.4946
>T215116 WP_032104592.1 NZ_CP082797:38973-39455 [Klebsiella pneumoniae]
MGMRPPEPLTPEHNIAEFCCQDQVLSEWLKKKALKNHRTGISRVFVVCAENTNRVIAYYCLASGSVHRNTVPGAYRRNAP
EALPVIVLGRLAVDAAWARKGLGAALLKDAIYRTEHIAIQVGVRALLVHALNDEVREFYTKFGFEPSIANALTLLFPIKT
MGMRPPEPLTPEHNIAEFCCQDQVLSEWLKKKALKNHRTGISRVFVVCAENTNRVIAYYCLASGSVHRNTVPGAYRRNAP
EALPVIVLGRLAVDAAWARKGLGAALLKDAIYRTEHIAIQVGVRALLVHALNDEVREFYTKFGFEPSIANALTLLFPIKT
Download Length: 483 bp
>T215116 NZ_CP110472:c57178-56603 [Pantoea anthophila]
ATGAACCACACACCTTATCCCGTAGTTTTAGATGCTTGTGTACTTTACCCGTCATTTCTACGGGATTTACTGATCCGCTT
AGGGCTGACTGGACTGTATCAGCCGAAATGGTCAGCCACTATTGAAGATGAATGGCAGCGGAATCTTTTGGCAAATAGGA
CTGATTTAACCCCGGAACAGATTCAACGCACCGCCGCACTGATGAATACAGTGGTTCCCGATGCGATGATTACAGGTTTT
GAACCGCTAATTGATAGTGTTGATTTACCTGACGTTGACGATCGCCACGTCGTCGCAGCTTCTGTTCGTAGCAATTCTGA
AATCATAGTGACGTTCAATCTTAAAGATTTTCCGGCACCGGCACTTAATGCTTTCGGTATAGAAGCGTTGCATCCTGATG
ATTTTGTGATGGATTTGTTCGATTTAAATCGCGCGCTCGTACTCTCGGCAGTAACTACGCAGCGTAGCAATCTGAGGAGA
CCGCCAATGTCAGTTGATGAATACTTAGAAGCCTTACTACGGCAAGGCATGGCGCAAACCGTAAAAGAGTTAAGCATGTA
TCGCTTGCTGATCTAG
ATGAACCACACACCTTATCCCGTAGTTTTAGATGCTTGTGTACTTTACCCGTCATTTCTACGGGATTTACTGATCCGCTT
AGGGCTGACTGGACTGTATCAGCCGAAATGGTCAGCCACTATTGAAGATGAATGGCAGCGGAATCTTTTGGCAAATAGGA
CTGATTTAACCCCGGAACAGATTCAACGCACCGCCGCACTGATGAATACAGTGGTTCCCGATGCGATGATTACAGGTTTT
GAACCGCTAATTGATAGTGTTGATTTACCTGACGTTGACGATCGCCACGTCGTCGCAGCTTCTGTTCGTAGCAATTCTGA
AATCATAGTGACGTTCAATCTTAAAGATTTTCCGGCACCGGCACTTAATGCTTTCGGTATAGAAGCGTTGCATCCTGATG
ATTTTGTGATGGATTTGTTCGATTTAAATCGCGCGCTCGTACTCTCGGCAGTAACTACGCAGCGTAGCAATCTGAGGAGA
CCGCCAATGTCAGTTGATGAATACTTAGAAGCCTTACTACGGCAAGGCATGGCGCAAACCGTAAAAGAGTTAAGCATGTA
TCGCTTGCTGATCTAG
Antitoxin
Download Length: 93 a.a. Molecular weight: 10708.23 Da Isoelectric Point: 4.5156
>AT215116 WP_016529519.1 NZ_CP082797:38704-38982 [Klebsiella pneumoniae]
MKPDIREAPINIRAKTSQRDLIDMAANLVSKSRTDFMLEVACREAQDILLDQRLFLLDDNQFNAFVEELDAPMTPERQAR
IDNLMSRKSPWE
MKPDIREAPINIRAKTSQRDLIDMAANLVSKSRTDFMLEVACREAQDILLDQRLFLLDDNQFNAFVEELDAPMTPERQAR
IDNLMSRKSPWE
Download Length: 279 bp
>AT215116 NZ_CP110472:c57639-57178 [Pantoea anthophila]
ATGACAAACTCAATTCTTGACAGCCTTAGCCTTCCGGCTAAAGGGGAGATTGAGGCAGCTGTACGTGGACAAAGGGAGCT
TGCCGCCTACCTCTCCACAAAAATGGAAACACAAAAAATTGCAATTCAGGACGCAGATAACATAACCCACCAGATCGAAC
TGCCAACGTCTTCACTGACGCTGCTTATGTCGATTTTAGGTGAACTGGCCCTCGGTAACGCGGTTCAAGTTGTTCCTGTA
CATGCAGAATTAACGACGCAGGAAGCAGCCAATATTCTGAATGTTTCACGCCCTCACATGGTGAAACTGCTGGAAGACGG
GAAGCTGCCTTTTCATAAAACAGGTCGCCACCGCCGCGTGCTTTTCGCCGATTTGATGAAGTACAAAGATCAGCGAGATA
GCGAAAGCAATAAAGCAATGCAGGAGTTGGCAGATCTAAGCCAGGAGCTTGGACTTTACTAA
ATGACAAACTCAATTCTTGACAGCCTTAGCCTTCCGGCTAAAGGGGAGATTGAGGCAGCTGTACGTGGACAAAGGGAGCT
TGCCGCCTACCTCTCCACAAAAATGGAAACACAAAAAATTGCAATTCAGGACGCAGATAACATAACCCACCAGATCGAAC
TGCCAACGTCTTCACTGACGCTGCTTATGTCGATTTTAGGTGAACTGGCCCTCGGTAACGCGGTTCAAGTTGTTCCTGTA
CATGCAGAATTAACGACGCAGGAAGCAGCCAATATTCTGAATGTTTCACGCCCTCACATGGTGAAACTGCTGGAAGACGG
GAAGCTGCCTTTTCATAAAACAGGTCGCCACCGCCGCGTGCTTTTCGCCGATTTGATGAAGTACAAAGATCAGCGAGATA
GCGAAAGCAATAAAGCAATGCAGGAGTTGGCAGATCTAAGCCAGGAGCTTGGACTTTACTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|