Detailed information of TA system TA215113

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4759026..4759542
• Replicon: chromosome
• Accession: NZ_CP082796
• Organism: Klebsiella pneumoniae strain SCAID PHRX2-2021 (20/245)

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: K8B77_RS22755
• Protein ID: WP_032446557.1
• Coordinates: 4759026..4759310 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: R4Y888
• Locus tag: K8B77_RS22760
• Protein ID: WP_002886901.1
• Coordinates: 4759300..4759542 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K8B77_RS22730 (4754422)	4754422..4754730	-	309	WP_002886907.1	PTS sugar transporter subunit IIB	-
K8B77_RS22735 (4754815)	4754815..4754988	+	174	WP_002886906.1	hypothetical protein	-
K8B77_RS22740 (4754991)	4754991..4755734	+	744	WP_032446555.1	MurR/RpiR family transcriptional regulator	-
K8B77_RS22745 (4756091)	4756091..4758229	+	2139	WP_032446556.1	anaerobic ribonucleoside-triphosphate reductase	-
K8B77_RS22750 (4758558)	4758558..4759022	+	465	WP_004178375.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
K8B77_RS22755 (4759026)	4759026..4759310	-	285	WP_032446557.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
K8B77_RS22760 (4759300)	4759300..4759542	-	243	WP_002886901.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
K8B77_RS22765 (4759620)	4759620..4761530	-	1911	WP_004152270.1	PRD domain-containing protein	-
K8B77_RS22770 (4761553)	4761553..4762707	-	1155	WP_002886900.1	lactonase family protein	-
K8B77_RS22775 (4762774)	4762774..4763514	-	741	WP_002886899.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-82)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11110.98 Da
• Isoelectric Point: 10.3787

>T215113 WP_032446557.1 NZ_CP082796:c4759310-4759026 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHLANKRL

Nucleotide

• Length: 285 bp

>T215113 NZ_CP110470:475960-476550 [Rhodococcus opacus]
GTGAAACGACTCGACCTGGTGGCCGGCTGCAACGGCGCCGGCAAGTCCACCTTCGTGGCCTTCACCCTCGCCCCCCTGCT
GCCAGCCAGCCCGCTCGTCAATGCCGACGAAATCGCCACACAACGATGGCCGGCAGATCCGGCCATCCACTCCTATGAGG
CGGCAGAGATCGCCGCGAAGACCCGAGCACATCTGCTCACCCTAGGGAAATCGTTCATCGCCGCGACGGTGTTCTCCCAT
CCGTCGAAGCTGGAGCTGATCGACCAAGCACGCACACACGACTACACCGTCGTCTTACATGTGGTGATGATTCCCGAGGA
ACTAGCGGTCCAGCGTGTGCGCTACCGGGCGCAAGCCGGCGGACACGAAGTGCCCGAAGACAAGATCCGCCAGCGATACC
AAAGAATATGGAGTCTGCTCGCTCAGGCGTTCCCACGGTCTGATCATGTGACCGTGTACGACAACAGCTCGAGCACCGGC
CCGCGCATCGTCGCCCAATTCACCGACGGACACCTCGTCGGCGAAGCCACCTGGCCCGCATGGACACCCGCAGAACTGAC
CTCGCACACCAGCCGGGGCGAGCACCCATAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9045.55 Da
• Isoelectric Point: 6.3340

>AT215113 WP_002886901.1 NZ_CP082796:c4759542-4759300 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Nucleotide

• Length: 243 bp

>AT215113 NZ_CP110470:475580-475963 [Rhodococcus opacus]
ATGCACAGCACTGGCGACAAGGTCACCCGCCTGGCAGCCGACCTGGTGGCCAGCGCCATGGCCGAGGGAGAACGGCAACA
CCGCACCGGACGCCAACAACTCGAACACTGGGCCCGGGTGGGACGTGCGGTCTCGAGCCGACAGACCGCGGCCCGCCGCC
GAGTAGAAGACGCCCTCGCCGGCCGGTTGCCGCTCGGCGAACTCGGACCCGAAGAAGGCACAGTGTTCAACGCCGAGATC
AACGCGGCGATCGAGGAACAACTGGCCACCACCGACTACGGCTCTACGCTTGCCGCCCAGGGAATCACCACCGTCGCACT
GTCCGAGGACGGTCAGATCATCGAGTACCGTCCCGACGGCACGCGCACAATCCTGCCCGAGTGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GLP0