Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 781028..781685 Replicon chromosome
Accession NZ_CP082796
Organism Klebsiella pneumoniae strain SCAID PHRX2-2021 (20/245)

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag K8B77_RS03910 Protein ID WP_002916310.1
Coordinates 781275..781685 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag K8B77_RS03905 Protein ID WP_002916312.1
Coordinates 781028..781294 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8B77_RS03880 (776184) 776184..777617 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
K8B77_RS03885 (777736) 777736..778464 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
K8B77_RS03890 (778514) 778514..778825 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
K8B77_RS03895 (778989) 778989..779648 + 660 WP_002916317.1 hemolysin III family protein -
K8B77_RS03900 (779799) 779799..780782 - 984 WP_023286864.1 tRNA-modifying protein YgfZ -
K8B77_RS03905 (781028) 781028..781294 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
K8B77_RS03910 (781275) 781275..781685 + 411 WP_002916310.1 protein YgfX Toxin
K8B77_RS03915 (781692) 781692..782213 - 522 WP_004144730.1 flavodoxin FldB -
K8B77_RS03920 (782314) 782314..783210 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
K8B77_RS03925 (783233) 783233..783946 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
K8B77_RS03930 (783952) 783952..785685 + 1734 WP_032445465.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T215100 WP_002916310.1 NZ_CP082796:781275-781685 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T215100 NZ_CP110404:c4059806-4059471 [Shigella sonnei]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT215100 WP_002916312.1 NZ_CP082796:781028-781294 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT215100 NZ_CP110404:c4060054-4059806 [Shigella sonnei]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References