Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4095299..4095956 Replicon chromosome
Accession NZ_CP082791
Organism Klebsiella pneumoniae strain KP4823

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag KCV57_RS19855 Protein ID WP_002916310.1
Coordinates 4095546..4095956 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag KCV57_RS19850 Protein ID WP_002916312.1
Coordinates 4095299..4095565 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KCV57_RS19825 (4090455) 4090455..4091888 - 1434 WP_032418366.1 6-phospho-beta-glucosidase -
KCV57_RS19830 (4092007) 4092007..4092735 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
KCV57_RS19835 (4092785) 4092785..4093096 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
KCV57_RS19840 (4093260) 4093260..4093919 + 660 WP_002916317.1 hemolysin III family protein -
KCV57_RS19845 (4094070) 4094070..4095053 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
KCV57_RS19850 (4095299) 4095299..4095565 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
KCV57_RS19855 (4095546) 4095546..4095956 + 411 WP_002916310.1 protein YgfX Toxin
KCV57_RS19860 (4095963) 4095963..4096484 - 522 WP_004144730.1 flavodoxin FldB -
KCV57_RS19865 (4096585) 4096585..4097481 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
KCV57_RS19870 (4097504) 4097504..4098217 + 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KCV57_RS19875 (4098223) 4098223..4099956 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T215082 WP_002916310.1 NZ_CP082791:4095546-4095956 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T215082 NZ_CP110398:c3144971-3144720 [Shigella sonnei]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT215082 WP_002916312.1 NZ_CP082791:4095299-4095565 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT215082 NZ_CP110398:c3144723-3144469 [Shigella sonnei]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References