Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 3639902..3640488 Replicon chromosome
Accession NZ_CP082791
Organism Klebsiella pneumoniae strain KP4823

Toxin (Protein)


Gene name doc Uniprot ID W8VD46
Locus tag KCV57_RS17495 Protein ID WP_002920800.1
Coordinates 3640120..3640488 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID W9B1V1
Locus tag KCV57_RS17490 Protein ID WP_004174006.1
Coordinates 3639902..3640123 (+) Length 74 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KCV57_RS17470 (3636059) 3636059..3636985 + 927 WP_002920807.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
KCV57_RS17475 (3636982) 3636982..3638259 + 1278 WP_004174005.1 branched chain amino acid ABC transporter permease LivM -
KCV57_RS17480 (3638256) 3638256..3639023 + 768 WP_002920803.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
KCV57_RS17485 (3639025) 3639025..3639738 + 714 WP_004145133.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
KCV57_RS17490 (3639902) 3639902..3640123 + 222 WP_004174006.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KCV57_RS17495 (3640120) 3640120..3640488 + 369 WP_002920800.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
KCV57_RS17500 (3640761) 3640761..3642077 + 1317 WP_004174008.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
KCV57_RS17505 (3642184) 3642184..3643071 + 888 WP_002920792.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
KCV57_RS17510 (3643068) 3643068..3643913 + 846 WP_004145129.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
KCV57_RS17515 (3643915) 3643915..3644985 + 1071 WP_004150074.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3636982..3648510 11528


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(13-86)

Antitoxin

(1-50)


Sequences


Toxin        


Download         Length: 123 a.a.        Molecular weight: 13552.92 Da        Isoelectric Point: 8.6410

>T215081 WP_002920800.1 NZ_CP082791:3640120-3640488 [Klebsiella pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

>T215081 NZ_CP110398:c3144723-3144469 [Shigella sonnei]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8151.15 Da        Isoelectric Point: 4.7769

>AT215081 WP_004174006.1 NZ_CP082791:3639902-3640123 [Klebsiella pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp

>AT215081 NZ_CP110398:c3144971-3144720 [Shigella sonnei]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0H3GUD1


Antitoxin

Source ID Structure
AlphaFold DB A0A5E5YJY7

References