Detailed information of TA system TA021508

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/YoeB-YefM
• Location: 2335717..2336225
• Replicon: chromosome
• Accession: NC_007912
• Organism: Saccharophagus degradans 2-40

Toxin (Protein)

• Gene name: relE
• Uniprot ID: Q21JM5
• Locus tag: SDE_RS09685
• Protein ID: WP_011468322.1
• Coordinates: 2335717..2335977 (-)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: Q21JM4
• Locus tag: SDE_RS09690
• Protein ID: WP_011468323.1
• Coordinates: 2335974..2336225 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SDE_RS09645	2331249..2331650	+	402	WP_011468314.1	DUF4259 domain-containing protein	-
SDE_RS09650	2331766..2332458	+	693	WP_011468315.1	hypothetical protein	-
SDE_RS09655	2332599..2332913	-	315	WP_011468316.1	helix-turn-helix domain-containing protein	-
SDE_RS09660	2332918..2333355	-	438	WP_011468317.1	SRPBCC family protein	-
SDE_RS09665	2333620..2334096	+	477	WP_011468318.1	aminoglycoside N-acetyltransferase AAC(3)-Ig	-
SDE_RS09670	2334243..2334857	+	615	WP_011468319.1	pyridoxamine 5'-phosphate oxidase family protein	-
SDE_RS09675	2334990..2335355	+	366	WP_011468320.1	DoxX family protein	-
SDE_RS09680	2335377..2335592	+	216	WP_011468321.1	DUF4287 domain-containing protein	-
SDE_RS09685	2335717..2335977	-	261	WP_011468322.1	Txe/YoeB family addiction module toxin	Toxin
SDE_RS09690	2335974..2336225	-	252	WP_011468323.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
SDE_RS09695	2336591..2337379	+	789	WP_011468324.1	hypothetical protein	-
SDE_RS09700	2337453..2337950	+	498	WP_011468325.1	ATP-binding protein	-
SDE_RS09705	2338168..2338755	-	588	WP_011468326.1	OmpA family protein	-
SDE_RS09710	2338983..2340245	-	1263	WP_158303871.1	acyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	aac(3)-Ig	-	2305630..2336384	30754

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10483.92 Da
• Isoelectric Point: 9.8547

>T21508 WP_011468322.1 NC_007912:c2335977-2335717 [Saccharophagus degradans 2-40]
MKQTFSSRAWEEYLNWQKTDKAMLKRINTLIKNTTRDPFDGIGKLEPLKHSLSGYWSRRINDEHRFVYKVSDDQLLIAQL
RYHYEY

Nucleotide

• Length: 261 bp

>T21508 NC_007912:c2335977-2335717 [Saccharophagus degradans 2-40]
ATGAAGCAGACCTTCTCTTCTAGGGCTTGGGAAGAGTATCTAAATTGGCAAAAGACCGATAAGGCGATGCTGAAGCGTAT
CAACACTCTAATTAAGAATACAACCCGAGATCCCTTTGATGGGATTGGTAAGCTAGAACCGCTCAAACATAGCCTTTCTG
GCTACTGGTCTCGACGGATTAATGATGAACATAGATTCGTTTATAAAGTCTCAGACGATCAACTTCTCATTGCGCAATTG
CGATATCACTACGAGTACTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9068.35 Da
• Isoelectric Point: 5.0773

>AT21508 WP_011468323.1 NC_007912:c2336225-2335974 [Saccharophagus degradans 2-40]
MDALSYTAARANLAKTMEKVCNDHAPVIITRKSEAPVVMVSLADYQAMEETAYLMRSPANARHLLESIAELEAGKGTERS
LSE

Nucleotide

• Length: 252 bp

>AT21508 NC_007912:c2336225-2335974 [Saccharophagus degradans 2-40]
ATGGACGCTTTAAGCTACACAGCCGCTAGAGCTAACCTAGCAAAAACTATGGAGAAAGTCTGCAATGACCATGCTCCGGT
CATTATTACCCGTAAAAGCGAGGCTCCCGTTGTTATGGTCTCACTTGCGGACTACCAAGCGATGGAAGAAACCGCGTACC
TTATGCGCTCTCCCGCCAATGCCAGGCACTTACTTGAGTCTATAGCCGAACTAGAGGCAGGCAAAGGAACTGAAAGGAGC
TTGAGTGAATGA

Structures

Toxin

• AlphaFold DB: Q21JM5

Antitoxin

• AlphaFold DB: Q21JM4