Detailed information of TA system TA215079

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 2921349..2923030
• Replicon: chromosome
• Accession: NZ_CP082791
• Organism: Klebsiella pneumoniae strain KP4823

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: J2XCI1
• Locus tag: KCV57_RS14165
• Protein ID: WP_004146663.1
• Coordinates: 2921349..2922266 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: KCV57_RS14170
• Protein ID: WP_032418188.1
• Coordinates: 2922272..2923030 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KCV57_RS14145 (2916655)	2916655..2918175	+	1521	WP_032418186.1	sugar ABC transporter ATP-binding protein	-
KCV57_RS14150 (2918172)	2918172..2919170	+	999	WP_002885172.1	ribose ABC transporter permease	-
KCV57_RS14155 (2919201)	2919201..2920142	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
KCV57_RS14160 (2920217)	2920217..2921224	+	1008	WP_032418187.1	carbohydrate kinase family protein	-
KCV57_RS14165 (2921349)	2921349..2922266	-	918	WP_004146663.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
KCV57_RS14170 (2922272)	2922272..2923030	-	759	WP_032418188.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
KCV57_RS14175 (2923116)	2923116..2923844	-	729	WP_004210017.1	response regulator transcription factor	-
KCV57_RS14180 (2924117)	2924117..2926264	+	2148	WP_077598926.1	formate dehydrogenase subunit alpha	-
KCV57_RS14185 (2926261)	2926261..2926404	-	144	WP_022631365.1	hypothetical protein	-
KCV57_RS14190 (2926610)	2926610..2927296	+	687	WP_004151733.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34659.10 Da
• Isoelectric Point: 5.4707

>T215079 WP_004146663.1 NZ_CP082791:c2922266-2921349 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

>T215079 NZ_CP110398:3028919-3029026 [Shigella sonnei]
ATGACGCTCGCGAAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28620.99 Da
• Isoelectric Point: 10.0001

>AT215079 WP_032418188.1 NZ_CP082791:c2923030-2922272 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPETLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT215079 NZ_CP110398:c3028862-3028806 [Shigella sonnei]
TCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTC

Structures

Toxin

• AlphaFold DB: J2XCI1