Detailed information of TA system TA215075

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 702561..704149
• Replicon: chromosome
• Accession: NZ_CP082791
• Organism: Klebsiella pneumoniae strain KP4823

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: KCV57_RS03540
• Protein ID: WP_004184027.1
• Coordinates: 702561..703883 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: KCV57_RS03545
• Protein ID: WP_004176198.1
• Coordinates: 703883..704149 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KCV57_RS03525 (697617)	697617..700118	+	2502	WP_032439971.1	fimbria/pilus outer membrane usher protein	-
KCV57_RS03530 (700106)	700106..701110	+	1005	WP_016946380.1	fimbrial protein	-
KCV57_RS03535 (701252)	701252..702544	+	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
KCV57_RS03540 (702561)	702561..703883	-	1323	WP_004184027.1	type II toxin-antitoxin system HipA family toxin	Toxin
KCV57_RS03545 (703883)	703883..704149	-	267	WP_004176198.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
KCV57_RS03550 (704415)	704415..704741	-	327	WP_004215084.1	hydroxyisourate hydrolase	-
KCV57_RS03555 (704738)	704738..705238	-	501	WP_032418978.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
KCV57_RS03560 (705216)	705216..706595	-	1380	WP_004184021.1	nucleobase:cation symporter-2 family protein	-
KCV57_RS03565 (706941)	706941..708095	+	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
KCV57_RS03570 (708076)	708076..708999	-	924	WP_032418980.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49139.47 Da
• Isoelectric Point: 7.5367

>T215075 WP_004184027.1 NZ_CP082791:c703883-702561 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T215075 NZ_CP110398:c1437894-1437676 [Shigella sonnei]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTATACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9936.36 Da
• Isoelectric Point: 8.5912

>AT215075 WP_004176198.1 NZ_CP082791:c704149-703883 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT215075 NZ_CP110398:c1438294-1437920 [Shigella sonnei]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGAGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG