Detailed information of TA system TA021507

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 1885497..1886103
• Replicon: chromosome
• Accession: NC_007908
• Organism: Albidiferax ferrireducens T118 (Rhodoferax ferrireducens T118)

Toxin (Protein)

• Gene name: relE
• Uniprot ID: Q21XM4
• Locus tag: RFER_RS08860
• Protein ID: WP_011464047.1
• Coordinates: 1885783..1886103 (+)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: RFER_RS08855
• Protein ID: WP_041791784.1
• Coordinates: 1885497..1885796 (+)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RFER_RS08835	1881352..1881954	+	603	WP_011464042.1	phosphatase PAP2 family protein	-
RFER_RS08840	1882251..1882997	-	747	WP_011464043.1	PE-PGRS family protein	-
RFER_RS08845	1883248..1884135	+	888	WP_011464044.1	hypothetical protein	-
RFER_RS08850	1884119..1885360	+	1242	WP_011464045.1	hypothetical protein	-
RFER_RS08855	1885497..1885796	+	300	WP_041791784.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
RFER_RS08860	1885783..1886103	+	321	WP_011464047.1	type II toxin-antitoxin system YafQ family toxin	Toxin
RFER_RS08865	1886103..1886858	+	756	WP_011464048.1	DNA repair protein RecO	-
RFER_RS08870	1886855..1887613	+	759	WP_011464049.1	pyridoxine 5'-phosphate synthase	-
RFER_RS08875	1887610..1888002	+	393	WP_011464050.1	holo-ACP synthase	-
RFER_RS08880	1888083..1889177	+	1095	WP_011464051.1	beta-N-acetylhexosaminidase	-
RFER_RS08885	1889174..1889401	-	228	WP_011464052.1	hypothetical protein	-
RFER_RS08890	1889597..1890811	+	1215	WP_041791788.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (10-104)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (3-71)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12255.14 Da
• Isoelectric Point: 8.5121

>T21507 WP_011464047.1 NC_007908:1885783-1886103 [Rhodoferax ferrireducens T118]
MAKTKARKLRQFEPLKAFDKDWEKLAHSGRHELTRLKVVMALLLDHEAPLPPEYLDHPLQGGWDGHRECHIGGDWLLIYR
LADVGSKTERVIFCRTGTHSALFGYY

Nucleotide

• Length: 321 bp

>T21507 NC_007908:1885783-1886103 [Rhodoferax ferrireducens T118]
ATGGCAAAAACTAAAGCGCGCAAGCTGCGGCAGTTTGAGCCACTCAAGGCTTTTGACAAAGACTGGGAAAAACTTGCACA
CAGTGGCCGTCATGAGCTGACGCGGCTCAAGGTGGTGATGGCTTTGTTGCTTGACCACGAGGCACCTTTACCCCCTGAAT
ATCTGGATCACCCGCTGCAAGGCGGCTGGGACGGTCACCGCGAGTGCCATATCGGCGGCGATTGGCTTTTGATTTACCGT
TTGGCCGATGTGGGCTCAAAGACCGAGAGAGTCATTTTTTGTCGAACGGGGACGCATTCAGCGTTGTTTGGCTACTACTG
A

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 10638.24 Da
• Isoelectric Point: 8.5954

>AT21507 WP_041791784.1 NC_007908:1885497-1885796 [Rhodoferax ferrireducens T118]
VEAVIKSRIDAGLKAEVEQVLSALGLTVSDVMRMTFAQIAARKGLPFDVKLPNAQTMDVLKESDAALNRLRAGAAPRFDS
LDNYFAAMDGKVARSDGKN

Nucleotide

• Length: 300 bp

>AT21507 NC_007908:1885497-1885796 [Rhodoferax ferrireducens T118]
GTGGAAGCCGTTATTAAAAGCCGCATCGACGCCGGTTTGAAGGCCGAGGTTGAACAAGTTCTGTCAGCCTTGGGTTTAAC
CGTCAGTGATGTGATGCGCATGACTTTTGCGCAAATCGCTGCGCGCAAGGGCTTGCCGTTTGATGTCAAGTTACCCAATG
CGCAAACGATGGATGTGCTGAAAGAATCAGACGCTGCACTGAATCGCTTGCGCGCCGGCGCTGCACCGCGCTTTGACTCT
TTGGACAATTATTTTGCTGCCATGGATGGCAAGGTGGCAAGGTCCGATGGCAAAAACTAA

Structures

Toxin

• AlphaFold DB: Q21XM4