Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2231311..2231825 Replicon chromosome
Accession NZ_CP082789
Organism Staphylococcus aureus strain HL24830

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag K3B00_RS11235 Protein ID WP_000581792.1
Coordinates 2231311..2231520 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag K3B00_RS11240 Protein ID WP_000138932.1
Coordinates 2231532..2231825 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K3B00_RS11215 (2226819) 2226819..2228177 - 1359 WP_000611470.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
K3B00_RS11220 (2228192) 2228192..2229262 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
K3B00_RS11225 (2229580) 2229580..2230782 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
K3B00_RS11230 (2231046) 2231046..2231183 - 138 WP_000828354.1 Lmo0850 family protein -
K3B00_RS11235 (2231311) 2231311..2231520 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
K3B00_RS11240 (2231532) 2231532..2231825 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
K3B00_RS11245 (2231991) 2231991..2233475 + 1485 WP_000571549.1 cardiolipin synthase -
K3B00_RS11250 (2233503) 2233503..2234150 + 648 WP_001187630.1 HD domain-containing protein -
K3B00_RS11255 (2234622) 2234622..2235494 - 873 WP_000725802.1 membrane protein insertase YidC -
K3B00_RS11260 (2235580) 2235580..2236221 - 642 WP_223065208.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T215068 WP_000581792.1 NZ_CP082789:c2231520-2231311 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T215068 NZ_CP110395:3486126-3486407 [Paraburkholderia sp. D15]
ATGATCACGACATTCGGCAACAAGGCTACGGCGGCAATCTTCGAGGGCAAGTTCGTGCGGTCACTGCCTCTGAACATGCA
GACACTCGCACGGCGCAAGCTCCTGATGATCGACGCCGCCGACTCCGTCCAGAACCTGCACGCGCCGCCCGGCAACCGGC
TCGAATCGTTGCAAGGCGACCGTTGCGGGCAATGGAGCATCCGCATCAACACGCAGTGGCGCATCTGCTTCCACTTCGTC
GAGGGGGAGGCGCTCAATGTCGAGATTGTCGACTATCACTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT215068 WP_000138932.1 NZ_CP082789:c2231825-2231532 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT215068 NZ_CP110395:3486424-3486879 [Paraburkholderia sp. D15]
ATGGTCATCAAACGCTCCGAACTGAGCGGCGTCGATTTCTCGGACGTCGCCACCGGCGACAACATCCCGGAAATCCACCC
GGGCGAGATTCTGCGTAGCGAGTTTCTCGACCCGCTCGGCATGTCCGTCAATGCGCTGGCGCTCGCGCTGCGCGTGCCGG
CACCGCGCATCAACGACGTCGTCCGCGGCAAGCGCGCGATCTCGGCGGACACCGCGCTGCGGCTCGAACGCTATCTGGGC
GCGAGCGCGCAGTTCTGGCTCAATCTGCAGATCGCCTACGACCTGCGCGTCGCCACGGCGGCCTCCGGCGCGCAGATCAC
GCGCGAAATCGAGCCCATGCCGAAGGCGGACCGGCCGAAGCTGCCCAGAATGAGCCCCGAGCACGCGCGCGCCGCCGCGC
TCGCCACCAGTCTGCGCCGCGACGCGGAAGAGGAAAGACCGCGGCGCAAGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References