Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) TscAT/-
Location 2159426..2159964 Replicon chromosome
Accession NZ_CP082789
Organism Staphylococcus aureus strain HL24830

Toxin (Protein)


Gene name TscT Uniprot ID A0A0H3K0C1
Locus tag K3B00_RS10870 Protein ID WP_001078344.1
Coordinates 2159426..2159752 (-) Length 109 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID A0A0H3JSN0
Locus tag K3B00_RS10875 Protein ID WP_001058495.1
Coordinates 2159755..2159964 (-) Length 70 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K3B00_RS10845 (2154650) 2154650..2154991 - 342 WP_001190615.1 hypothetical protein -
K3B00_RS10850 (2155441) 2155441..2156082 - 642 WP_001047698.1 hypothetical protein -
K3B00_RS10855 (2156079) 2156079..2156459 - 381 WP_000356942.1 hypothetical protein -
K3B00_RS10860 (2156769) 2156769..2158478 - 1710 WP_000447473.1 DUF927 domain-containing protein -
K3B00_RS10865 (2158492) 2158492..2159361 - 870 WP_209498897.1 primase alpha helix C-terminal domain-containing protein -
K3B00_RS10870 (2159426) 2159426..2159752 - 327 WP_001078344.1 DUF1474 family protein Toxin
K3B00_RS10875 (2159755) 2159755..2159964 - 210 WP_001058495.1 hypothetical protein Antitoxin
K3B00_RS10880 (2159957) 2159957..2160103 - 147 WP_000784885.1 hypothetical protein -
K3B00_RS10885 (2160100) 2160100..2160417 - 318 WP_000481967.1 helix-turn-helix domain-containing protein -
K3B00_RS10890 (2160422) 2160422..2160640 - 219 WP_209498898.1 helix-turn-helix transcriptional regulator -
K3B00_RS10895 (2160813) 2160813..2161487 + 675 WP_000620857.1 helix-turn-helix transcriptional regulator -
K3B00_RS10900 (2161501) 2161501..2162673 + 1173 WP_209498900.1 tyrosine-type recombinase/integrase -
K3B00_RS10905 (2162742) 2162742..2164358 - 1617 WP_000240642.1 chaperonin GroEL -
K3B00_RS10910 (2164434) 2164434..2164718 - 285 WP_000917289.1 co-chaperone GroES -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - scn / sak / hlb / sell / sec / tsst-1 / groEL 2096119..2164718 68599


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-100)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 109 a.a.        Molecular weight: 12968.26 Da        Isoelectric Point: 4.3050

>T215066 WP_001078344.1 NZ_CP082789:c2159752-2159426 [Staphylococcus aureus]
MNREIKDLFSDLKLLKDSFEDLKDSNGWHFDELYPYEPNHVLNKDELIGEGFSYHERRIHNNQMFDLFHLYIEQFDNIIE
KFYEIEKASSENFGEESDDAKNSIKVAE

Download         Length: 327 bp

>T215066 NZ_CP110395:1952720-1953136 [Paraburkholderia sp. D15]
TTGTATTTGATTGATACCAACGTCATCAGCGAGATCAGGCGTTGGGAGCGGGCGAATGCCGGCGTGCGGCGATTTTTCCG
GCAAGCCGAGCAGGAGGGGCGAAAGCTCTATCTTTCGGTCGTTACAGTCGGCGAACTGAGGCGCGGCGTCGAGCAGGTGC
GCTATCGCGGGGATCTGATGCAGGCGGCCGTACTTGAGCGTTGGATGAACACGGTGCTAAAGCGATTTGCCAAAAGCATT
CTGTCGATCGACGAGATTGCGGCTCACGTCTGGGGCAAGTTGCGGGTGCCGCATTCTGAGCCGGCCGTCGACAAGTTGAT
TGCCGCGACCGCATTGTCGTGCGATCTGGTAGTGGTAACGCGTAACGTGGCGGACTTCGCGGGACCGGGGATACGCGTGG
TCAATCCGTTCGATTGA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8206.22 Da        Isoelectric Point: 4.3718

>AT215066 WP_001058495.1 NZ_CP082789:c2159964-2159755 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSVVNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp

>AT215066 NZ_CP110395:1952497-1952733 [Paraburkholderia sp. D15]
ATGGCAAATTTATGGGTTCATAGTGTCGACGACACCTTGTTCGACACGCTTGTTCGGGAAGCCGAAGCGAATGGACGGTC
GGTGGAGGAAGAGCACCGGTTCATTCTCGAGGAAGCATTGCAGACGGTCTACAACCGCCAGTTCATCCGGGCATTGATGA
GCATGCCCAACGTCGGCGAAGACGCCGACTTCGAGCGGGTCAACGACAGACGCGAGGCTCCCGTTGTATTTGATTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0H3K0C1


Antitoxin

Source ID Structure
AlphaFold DB A0A0H3JSN0

References