Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 863195..863672 Replicon chromosome
Accession NZ_CP082789
Organism Staphylococcus aureus strain HL24830

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag K3B00_RS04130 Protein ID WP_000052076.1
Coordinates 863195..863383 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag K3B00_RS04135 Protein ID WP_001059690.1
Coordinates 863412..863672 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K3B00_RS04100 (859185) 859185..859706 + 522 WP_000824484.1 hypothetical protein -
K3B00_RS04105 (860047) 860047..860733 + 687 WP_001792695.1 thermonuclease family protein -
K3B00_RS04110 (861090) 861090..861290 + 201 WP_001059082.1 cold-shock protein -
K3B00_RS04115 (861786) 861786..862004 - 219 WP_000005886.1 hypothetical protein -
K3B00_RS04120 (862066) 862066..862350 - 285 WP_001004395.1 hypothetical protein -
K3B00_RS04125 (862438) 862438..862872 - 435 WP_262409921.1 lipoprotein N-acylation protein LnsA -
K3B00_RS04130 (863195) 863195..863383 - 189 WP_000052076.1 hypothetical protein Toxin
K3B00_RS04135 (863412) 863412..863672 - 261 WP_001059690.1 hypothetical protein Antitoxin
K3B00_RS04140 (864013) 864013..864216 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
K3B00_RS04145 (864213) 864213..864449 - 237 WP_000368687.1 hypothetical protein -
K3B00_RS04150 (864674) 864674..865255 + 582 WP_001140693.1 histidine phosphatase family protein -
K3B00_RS04155 (865328) 865328..865945 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
K3B00_RS04160 (866100) 866100..866594 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
K3B00_RS04165 (866993) 866993..867415 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
K3B00_RS04170 (867563) 867563..868279 + 717 WP_000150012.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-113)

Antitoxin

Helix-turn-helix domain, group 17

(80-127)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T215055 WP_000052076.1 NZ_CP082789:c863383-863195 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T215055 NZ_CP110376:3242087-3242656 [Proteus mirabilis]
ATGACAAACTATACTGTTTTGCTTGATGCCTGTGTCATGTATCCAGCCCCTCTTAGAAGTTATTTAATGTATCTTGCTAA
TACTGGTTTATTTAGAGCACGTTGGAGTAATCAGATCCATGATGAATGGATCACTAATTTATTAGTCAACAATCCAACAT
TAACAGCTGAGCGACTAATACGAACCAGAGATTTAATGAATGCACATGTTCCTGATTGTTTAGTAGAAGGCTACGAACCG
CTTATTTGTGGTTTAAAGCTACCTGATCCTAATGATCGTCATGTGCTAGCAGCAGCAATAAAAGGGCAGGCTCAAGCTAT
AATTACATTTAACTTAAAAGATTTTCCGCAAAAATACCTTAATTCTTTTGATATTTCAGCTATCCATCCTGATGAATTTT
TGAGTGACATGTTTGAATTAAATCCTAGTAGCTGTATTAAAGCGGCGCAACAACATAGACAAAGCCTAAAGAATCCACCA
ATGACCGTAGAGACCTTTTTAGGCTGTTTACAAAAGCAGAAATTACCCCAGTTTATTTCCCATTTACGGGCATTCCAGAT
ATTATTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT215055 WP_001059690.1 NZ_CP082789:c863672-863412 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT215055 NZ_CP110376:3241635-3242087 [Proteus mirabilis]
ATGAATACGATAAGTGAGAGACTTAGTGCTGAAGATATTGCATTAGCAAAATTAAGTAGCCAAGAGCTATCCGCTGTTAT
GGATATTAATGGCAAAACGCAGAAGCTATCCATTATAGATAAGACGGGTAATAATCATATTGTACAAATACCAAATAGTG
CATTACGCCTAATGATTGAAATTCTTACTCAACTAGGGCAAGGGAATACTGTTAGTATCACACCAATCCATGCTGAGCTA
ACGACACAGGAAGCGGCTGATATACTCAATATGTCCCGTCCTACATTTGTAAAATTATTAGATACACGAGCGATACCCTA
CTCTAGAAAAGGAAATCGTAGGAAAGTTGCTTATGCTGATATTGTTGCTTATAAAAATGAATTGGAGCAAAAACGACTTG
ATGCCCTTGCTGAATTATCGCAATTAGATCAAGAAATGGATATGGGGTATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References