Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) TscAT/-
Location 837843..838372 Replicon chromosome
Accession NZ_CP082789
Organism Staphylococcus aureus strain HL24830

Toxin (Protein)


Gene name TscT Uniprot ID K7ZRX2
Locus tag K3B00_RS03985 Protein ID WP_001103933.1
Coordinates 838055..838372 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID A0A6B0BJC0
Locus tag K3B00_RS03980 Protein ID WP_001058487.1
Coordinates 837843..838052 (+) Length 70 a.a.

Genomic Context


K3B00_RS03945K3B00_RS03965K3B00_RS03970K3B00_RS03975K3B00_RS03980K3B00_RS03985K3B00_RS03990K3B00_RS03995K3B00_RS04000K3B00_RS04005K3B00_RS04010K3B00_RS04015K3B00_RS03955K3B00_RS03960
Location: 834294..834758 (465 bp)
Type: Others
Protein ID: WP_001085185.1
Location: 837238..837444 (207 bp)
Type: Others
Protein ID: WP_001060953.1
Location: 837480..837707 (228 bp)
Type: Others
Protein ID: WP_000164237.1
Location: 837704..837850 (147 bp)
Type: Others
Protein ID: WP_000784893.1
Location: 837843..838052 (210 bp)
Type: Antitoxin
Protein ID: WP_001058487.1
Location: 838055..838372 (318 bp)
Type: Toxin
Protein ID: WP_001103933.1
Location: 838439..839308 (870 bp)
Type: Others
Protein ID: WP_001002695.1
Location: 839325..840794 (1470 bp)
Type: Others
Protein ID: WP_001668899.1
Location: 841080..841442 (363 bp)
Type: Others
Protein ID: WP_001039169.1
Location: 841444..841728 (285 bp)
Type: Others
Protein ID: WP_000998179.1
Location: 841725..842366 (642 bp)
Type: Others
Protein ID: WP_063663413.1
Location: 842816..843157 (342 bp)
Type: Others
Protein ID: WP_001190615.1
Location: 835321..836427 (1107 bp)
Type: Others
Protein ID: WP_000121223.1
Location: 836433..837050 (618 bp)
Type: Others
Protein ID: WP_223200480.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
K3B00_RS03945 (834294)834294..834758+465WP_001085185.1SsrA-binding protein SmpB-
K3B00_RS03955 (835321)835321..836427-1107WP_000121223.1tyrosine-type recombinase/integrase-
K3B00_RS03960 (836433)836433..837050-618WP_223200480.1helix-turn-helix transcriptional regulator-
K3B00_RS03965 (837238)837238..837444+207WP_001060953.1hypothetical protein-
K3B00_RS03970 (837480)837480..837707+228WP_000164237.1helix-turn-helix transcriptional regulator-
K3B00_RS03975 (837704)837704..837850+147WP_000784893.1hypothetical protein-
K3B00_RS03980 (837843)837843..838052+210WP_001058487.1hypothetical proteinAntitoxin
K3B00_RS03985 (838055)838055..838372+318WP_001103933.1DUF1474 family proteinToxin
K3B00_RS03990 (838439)838439..839308+870WP_001002695.1primase alpha helix C-terminal domain-containing protein-
K3B00_RS03995 (839325)839325..840794+1470WP_001668899.1virulence-associated E family protein-
K3B00_RS04000 (841080)841080..841442+363WP_001039169.1hypothetical protein-
K3B00_RS04005 (841444)841444..841728+285WP_000998179.1hypothetical protein-
K3B00_RS04010 (841725)841725..842366+642WP_063663413.1pathogenicity island protein-
K3B00_RS04015 (842816)842816..843157+342WP_001190615.1hypothetical protein-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-98)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 106 a.a.        Molecular weight: 12511.13 Da        Isoelectric Point: 4.6364

>T215054 WP_001103933.1 NZ_CP082789:838055-838372 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKEKINDVAIKHGWFVEDKFVKNELETKQEHINFSASYLEHRIQNEHTVELLQVYLKEFGELIQKF
HEIEKASSENFGEESDDAKKLKITE

Download         Length: 318 bp

>T215054 NZ_CP110376:1931072-1931230 [Proteus mirabilis]
ATGCGGACTACTGACAAAGTAGTTCAAGGTAATACGGGAACAACACATATCGGTTACCCAGCTAATATTGATGCTTTTGG
TAAACAAGCTAAGCTGGGAGCAGTATATGTTGAATTTAGTGTGCCTAAAGAATCGTTGATAAAAACAAATGATGAATAG

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8228.24 Da        Isoelectric Point: 4.1682

>AT215054 WP_001058487.1 NZ_CP082789:837843-838052 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSIMNNFESYEHTEYVDGIEVVSEISPEKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp

>AT215054 NZ_CP110376:1930847-1931068 [Proteus mirabilis]
ATGGCTGTATCAATCTGGAGAGATGATGAAGAAAGTGGCTTGTATTATAATCGCTTCCGTTATTATGATAAGGAGACAGG
GCAGTATCTTTCCCCAGATCCGATAGGGCTGCTAGGTAGTGTGAATCCGTATGGATATGTCCATAATCTAGTCAATTTTA
TTGACCCTTTTGGATTATCAACTGTTACTGTTGGTCGTTGGATGAGTCCAGATGAACTCTAA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBK7ZRX2


Antitoxin

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Source
ID
Structure
AlphaFold DBA0A6B0BJC0

References