Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 837843..838372 Replicon chromosome
Accession NZ_CP082789
Organism Staphylococcus aureus strain HL24830

Toxin (Protein)


Gene name TscT Uniprot ID K7ZRX2
Locus tag K3B00_RS03985 Protein ID WP_001103933.1
Coordinates 838055..838372 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID A0A6B0BJC0
Locus tag K3B00_RS03980 Protein ID WP_001058487.1
Coordinates 837843..838052 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K3B00_RS03945 (834294) 834294..834758 + 465 WP_001085185.1 SsrA-binding protein SmpB -
K3B00_RS03955 (835321) 835321..836427 - 1107 WP_000121223.1 tyrosine-type recombinase/integrase -
K3B00_RS03960 (836433) 836433..837050 - 618 WP_223200480.1 helix-turn-helix transcriptional regulator -
K3B00_RS03965 (837238) 837238..837444 + 207 WP_001060953.1 hypothetical protein -
K3B00_RS03970 (837480) 837480..837707 + 228 WP_000164237.1 helix-turn-helix transcriptional regulator -
K3B00_RS03975 (837704) 837704..837850 + 147 WP_000784893.1 hypothetical protein -
K3B00_RS03980 (837843) 837843..838052 + 210 WP_001058487.1 hypothetical protein Antitoxin
K3B00_RS03985 (838055) 838055..838372 + 318 WP_001103933.1 DUF1474 family protein Toxin
K3B00_RS03990 (838439) 838439..839308 + 870 WP_001002695.1 primase alpha helix C-terminal domain-containing protein -
K3B00_RS03995 (839325) 839325..840794 + 1470 WP_001668899.1 virulence-associated E family protein -
K3B00_RS04000 (841080) 841080..841442 + 363 WP_001039169.1 hypothetical protein -
K3B00_RS04005 (841444) 841444..841728 + 285 WP_000998179.1 hypothetical protein -
K3B00_RS04010 (841725) 841725..842366 + 642 WP_063663413.1 pathogenicity island protein -
K3B00_RS04015 (842816) 842816..843157 + 342 WP_001190615.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-98)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12511.13 Da        Isoelectric Point: 4.6364

>T215054 WP_001103933.1 NZ_CP082789:838055-838372 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKEKINDVAIKHGWFVEDKFVKNELETKQEHINFSASYLEHRIQNEHTVELLQVYLKEFGELIQKF
HEIEKASSENFGEESDDAKKLKITE

Download         Length: 318 bp

>T215054 NZ_CP110376:1931072-1931230 [Proteus mirabilis]
ATGCGGACTACTGACAAAGTAGTTCAAGGTAATACGGGAACAACACATATCGGTTACCCAGCTAATATTGATGCTTTTGG
TAAACAAGCTAAGCTGGGAGCAGTATATGTTGAATTTAGTGTGCCTAAAGAATCGTTGATAAAAACAAATGATGAATAG

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8228.24 Da        Isoelectric Point: 4.1682

>AT215054 WP_001058487.1 NZ_CP082789:837843-838052 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSIMNNFESYEHTEYVDGIEVVSEISPEKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp

>AT215054 NZ_CP110376:1930847-1931068 [Proteus mirabilis]
ATGGCTGTATCAATCTGGAGAGATGATGAAGAAAGTGGCTTGTATTATAATCGCTTCCGTTATTATGATAAGGAGACAGG
GCAGTATCTTTCCCCAGATCCGATAGGGCTGCTAGGTAGTGTGAATCCGTATGGATATGTCCATAATCTAGTCAATTTTA
TTGACCCTTTTGGATTATCAACTGTTACTGTTGGTCGTTGGATGAGTCCAGATGAACTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K7ZRX2

Antitoxin

Source ID Structure
AlphaFold DB A0A6B0BJC0

References