Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | TscAT/- |
Location | 837843..838372 | Replicon | chromosome |
Accession | NZ_CP082789 | ||
Organism | Staphylococcus aureus strain HL24830 |
Toxin (Protein)
Gene name | TscT | Uniprot ID | K7ZRX2 |
Locus tag | K3B00_RS03985 | Protein ID | WP_001103933.1 |
Coordinates | 838055..838372 (+) | Length | 106 a.a. |
Antitoxin (Protein)
Gene name | TscA | Uniprot ID | A0A6B0BJC0 |
Locus tag | K3B00_RS03980 | Protein ID | WP_001058487.1 |
Coordinates | 837843..838052 (+) | Length | 70 a.a. |
Genomic Context
Location: 834294..834758 (465 bp)
Type: Others
Protein ID: WP_001085185.1
Type: Others
Protein ID: WP_001085185.1
Location: 837238..837444 (207 bp)
Type: Others
Protein ID: WP_001060953.1
Type: Others
Protein ID: WP_001060953.1
Location: 837480..837707 (228 bp)
Type: Others
Protein ID: WP_000164237.1
Type: Others
Protein ID: WP_000164237.1
Location: 837704..837850 (147 bp)
Type: Others
Protein ID: WP_000784893.1
Type: Others
Protein ID: WP_000784893.1
Location: 837843..838052 (210 bp)
Type: Antitoxin
Protein ID: WP_001058487.1
Type: Antitoxin
Protein ID: WP_001058487.1
Location: 838055..838372 (318 bp)
Type: Toxin
Protein ID: WP_001103933.1
Type: Toxin
Protein ID: WP_001103933.1
Location: 838439..839308 (870 bp)
Type: Others
Protein ID: WP_001002695.1
Type: Others
Protein ID: WP_001002695.1
Location: 839325..840794 (1470 bp)
Type: Others
Protein ID: WP_001668899.1
Type: Others
Protein ID: WP_001668899.1
Location: 841080..841442 (363 bp)
Type: Others
Protein ID: WP_001039169.1
Type: Others
Protein ID: WP_001039169.1
Location: 841444..841728 (285 bp)
Type: Others
Protein ID: WP_000998179.1
Type: Others
Protein ID: WP_000998179.1
Location: 841725..842366 (642 bp)
Type: Others
Protein ID: WP_063663413.1
Type: Others
Protein ID: WP_063663413.1
Location: 842816..843157 (342 bp)
Type: Others
Protein ID: WP_001190615.1
Type: Others
Protein ID: WP_001190615.1
Location: 835321..836427 (1107 bp)
Type: Others
Protein ID: WP_000121223.1
Type: Others
Protein ID: WP_000121223.1
Location: 836433..837050 (618 bp)
Type: Others
Protein ID: WP_223200480.1
Type: Others
Protein ID: WP_223200480.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
K3B00_RS03945 (834294) | 834294..834758 | + | 465 | WP_001085185.1 | SsrA-binding protein SmpB | - |
K3B00_RS03955 (835321) | 835321..836427 | - | 1107 | WP_000121223.1 | tyrosine-type recombinase/integrase | - |
K3B00_RS03960 (836433) | 836433..837050 | - | 618 | WP_223200480.1 | helix-turn-helix transcriptional regulator | - |
K3B00_RS03965 (837238) | 837238..837444 | + | 207 | WP_001060953.1 | hypothetical protein | - |
K3B00_RS03970 (837480) | 837480..837707 | + | 228 | WP_000164237.1 | helix-turn-helix transcriptional regulator | - |
K3B00_RS03975 (837704) | 837704..837850 | + | 147 | WP_000784893.1 | hypothetical protein | - |
K3B00_RS03980 (837843) | 837843..838052 | + | 210 | WP_001058487.1 | hypothetical protein | Antitoxin |
K3B00_RS03985 (838055) | 838055..838372 | + | 318 | WP_001103933.1 | DUF1474 family protein | Toxin |
K3B00_RS03990 (838439) | 838439..839308 | + | 870 | WP_001002695.1 | primase alpha helix C-terminal domain-containing protein | - |
K3B00_RS03995 (839325) | 839325..840794 | + | 1470 | WP_001668899.1 | virulence-associated E family protein | - |
K3B00_RS04000 (841080) | 841080..841442 | + | 363 | WP_001039169.1 | hypothetical protein | - |
K3B00_RS04005 (841444) | 841444..841728 | + | 285 | WP_000998179.1 | hypothetical protein | - |
K3B00_RS04010 (841725) | 841725..842366 | + | 642 | WP_063663413.1 | pathogenicity island protein | - |
K3B00_RS04015 (842816) | 842816..843157 | + | 342 | WP_001190615.1 | hypothetical protein | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
No matching records found |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 106 a.a. Molecular weight: 12511.13 Da Isoelectric Point: 4.6364
>T215054 WP_001103933.1 NZ_CP082789:838055-838372 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKEKINDVAIKHGWFVEDKFVKNELETKQEHINFSASYLEHRIQNEHTVELLQVYLKEFGELIQKF
HEIEKASSENFGEESDDAKKLKITE
MNWEIKDLMCDIEVIKEKINDVAIKHGWFVEDKFVKNELETKQEHINFSASYLEHRIQNEHTVELLQVYLKEFGELIQKF
HEIEKASSENFGEESDDAKKLKITE
Download Length: 318 bp
>T215054 NZ_CP110376:1931072-1931230 [Proteus mirabilis]
ATGCGGACTACTGACAAAGTAGTTCAAGGTAATACGGGAACAACACATATCGGTTACCCAGCTAATATTGATGCTTTTGG
TAAACAAGCTAAGCTGGGAGCAGTATATGTTGAATTTAGTGTGCCTAAAGAATCGTTGATAAAAACAAATGATGAATAG
ATGCGGACTACTGACAAAGTAGTTCAAGGTAATACGGGAACAACACATATCGGTTACCCAGCTAATATTGATGCTTTTGG
TAAACAAGCTAAGCTGGGAGCAGTATATGTTGAATTTAGTGTGCCTAAAGAATCGTTGATAAAAACAAATGATGAATAG
Antitoxin
Download Length: 70 a.a. Molecular weight: 8228.24 Da Isoelectric Point: 4.1682
>AT215054 WP_001058487.1 NZ_CP082789:837843-838052 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSIMNNFESYEHTEYVDGIEVVSEISPEKHLELIMKWCAQELKNNFQLEKGE
MNNEQKEVIEHVVYQLELSIMNNFESYEHTEYVDGIEVVSEISPEKHLELIMKWCAQELKNNFQLEKGE
Download Length: 210 bp
>AT215054 NZ_CP110376:1930847-1931068 [Proteus mirabilis]
ATGGCTGTATCAATCTGGAGAGATGATGAAGAAAGTGGCTTGTATTATAATCGCTTCCGTTATTATGATAAGGAGACAGG
GCAGTATCTTTCCCCAGATCCGATAGGGCTGCTAGGTAGTGTGAATCCGTATGGATATGTCCATAATCTAGTCAATTTTA
TTGACCCTTTTGGATTATCAACTGTTACTGTTGGTCGTTGGATGAGTCCAGATGAACTCTAA
ATGGCTGTATCAATCTGGAGAGATGATGAAGAAAGTGGCTTGTATTATAATCGCTTCCGTTATTATGATAAGGAGACAGG
GCAGTATCTTTCCCCAGATCCGATAGGGCTGCTAGGTAGTGTGAATCCGTATGGATATGTCCATAATCTAGTCAATTTTA
TTGACCCTTTTGGATTATCAACTGTTACTGTTGGTCGTTGGATGAGTCCAGATGAACTCTAA
Structures
Toxin
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Source | ID | Structure |
---|---|---|
AlphaFold DB | K7ZRX2 |
Antitoxin
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Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A6B0BJC0 |