Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4049077..4049746 Replicon chromosome
Accession NZ_CP082787
Organism Serratia entomophila strain A1

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag KHA73_RS19575 Protein ID WP_234586127.1
Coordinates 4049077..4049499 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID -
Locus tag KHA73_RS19580 Protein ID WP_234586128.1
Coordinates 4049480..4049746 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KHA73_RS19555 (KHA73_19565) 4044961..4045479 + 519 WP_234586120.1 flavodoxin FldB -
KHA73_RS19560 (KHA73_19570) 4045516..4046883 - 1368 WP_234586122.1 cell envelope integrity protein CreD -
KHA73_RS19565 (KHA73_19575) 4046967..4048385 - 1419 WP_234586124.1 two-component system sensor histidine kinase CreC -
KHA73_RS19570 (KHA73_19580) 4048382..4049077 - 696 WP_234586126.1 two-component system response regulator CreB -
KHA73_RS19575 (KHA73_19585) 4049077..4049499 - 423 WP_234586127.1 protein YgfX Toxin
KHA73_RS19580 (KHA73_19590) 4049480..4049746 - 267 WP_234586128.1 FAD assembly factor SdhE Antitoxin
KHA73_RS19585 (KHA73_19595) 4050070..4051062 + 993 WP_234586129.1 tRNA-modifying protein YgfZ -
KHA73_RS19590 (KHA73_19600) 4051099..4051596 - 498 WP_234586130.1 DUF2165 domain-containing protein -
KHA73_RS19595 (KHA73_19605) 4051737..4052411 - 675 WP_234586131.1 hemolysin III family protein -
KHA73_RS19600 (KHA73_19610) 4052595..4053203 + 609 WP_234586132.1 HD domain-containing protein -
KHA73_RS19605 (KHA73_19615) 4053245..4054174 - 930 WP_234586133.1 ribokinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 4041672..4107755 66083


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 16590.64 Da        Isoelectric Point: 10.6004

>T215050 WP_234586127.1 NZ_CP082787:c4049499-4049077 [Serratia entomophila]
VAQWRCDVRVSWRTQLFSLLTHGLLILLILVSPWPEGFWVIWLVLLTLVVFQCIRSQKRIAAVQGELRLLADRRFSWHGR
EWLLAKKPWMPGYGMLLTLQPMEGKKRRRLWLASDSMSKEEWRHLRQLLLYPPAGDDEDA

Download         Length: 423 bp

>T215050 NZ_CP110375:4091279-4092592 [Proteus mirabilis]
ATGGCGAGTCTTGATGTATATATGAATGAATACTATGTGGGCATCTTTACTAAAAAAAGCTCAGGTGCGCATTCATTCCA
ATATACTGAAGATTGGGTTAATCAACCAGGAAGTCGTCCCATCTCTCTTTCGATGCCATTACAGCTTCAAGAATATCAAG
GAGACTGTGTCTATAATTTCTTTGATAATCTGTTACCTGATAATACTGAAATTAGAAATCGTATTGTGAGTCGCTATAAT
GCGAACTCAAATCAACCCTTTGACCTATTAGCGGCTATCGGTGCAGATACTGTTGGTGCATTAAGGTTACTTCCTAGTGG
CAGTACGCCTGCGGATATCAAAAAAATAGAATATCAAAAACTCAATGATACTGAGCTTGAAAAAATTCTACTAGGATATA
AATCCAATACTCCACTCGGTATGCTTAAAGAATATACTGATTTCAGAATTTCCATCGCTGGAGCACAAGAAAAAACGGCA
TTACTTTTAAAAGATAATCATTGGTGTGTGCCACATAATAACACACCAACTACCCATATTATTAAACTGCCAATTGGTGT
TATTGAAAGTCATTCTTATACAATGGATTTATCCAATAGTGTAGAAAATGAGTATCTTTGTACCTTAATTGCCAAAGAAT
TTGATCTTCCCGTCCCCCACTGCTCTATTATTAAAACAAAAAATGTTAAAGCGCTTGCTGTAGAACGTTTCGATAGAAAA
TATTCATCTGATAAATCGTGGATAATACGTTTACCTCAAGAAGATTTTTGCCAAATTTTAAATATACCTTCTGCGCTAAA
ATATGAAAATGAAGGAGGGCCTGGCATTATCGATATTATGAAATATTTACTTGGTTCATCAAATGCCGATCAAGATCGTT
TTCATTTTATGAAGGCACAAGTGCTATTTTGGCTTTTGGCTGCAACGGATGGACACGCAAAGAATTTTTCTGTTTTTATC
AACCAAGAAGGACGTTTCCATCTCACTCCCCTTTATGACATTATGTCCATCTATCCCAATTTCGGAGGACGAGGACTTAA
TCCACGAGATGCAAAACTTGCTATGGGATTAAAAGCAAGCCGAGGCAAAAAATACGCAATAGAACAAATTTTTCCTCGTC
ATTTCTACCAAACAGCTGAAGCTGTCGGTTTCGATCCTTCATTAATGAGCGATATTCTTCGTTATTTTTATCAAGAAATG
GACGATGTCATACAACGCGTAAAACAGCAATTACCCGAGGATTTCCCTTCTGAGATTAGCAATACAATATTAGATGGAAT
GAAAGCACGCGCTGTTAGATTAGCTAACATTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10458.96 Da        Isoelectric Point: 4.7921

>AT215050 WP_234586128.1 NZ_CP082787:c4049746-4049480 [Serratia entomophila]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDQLNDTDKALFIRLLECDDPDLFNWLMNHGAPQDSELQRMVALIQTRN
KDRGPVAM

Download         Length: 267 bp

>AT215050 NZ_CP110375:4091021-4091278 [Proteus mirabilis]
ATGATCATAATTAATGCCTATCAACTCAGTGTGCATCTAAAAGATGTCCGATTAACAAAAAAACTGTCTCAAAGTAAAGT
CGCCCAAAAAGTAGGGATCCGACAAGATACCGTGTCCAATTTTGAACTTAATCCTAATTCCACCAAACTAGAAACCTTTT
TCAAACTGCTCTCCGCACTAAATTTAGAGATGGAAATTCATCCTAAAGATGCTAAAAATAATTTAGCACACAAAAGTGAA
TGGAAAGAGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References