Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 160688..161427 Replicon chromosome
Accession NZ_CP082787
Organism Serratia entomophila strain A1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KHA73_RS00650 Protein ID WP_234587439.1
Coordinates 160688..161167 (-) Length 160 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KHA73_RS00655 Protein ID WP_234587441.1
Coordinates 161164..161427 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KHA73_RS00625 (KHA73_00620) 156234..156707 - 474 WP_234587432.1 transcription elongation factor GreB -
KHA73_RS00630 (KHA73_00625) 156983..157942 + 960 WP_234587434.1 curved DNA-binding protein -
KHA73_RS00635 (KHA73_00630) 157945..158259 + 315 WP_234587436.1 chaperone modulator CbpM -
KHA73_RS00640 (KHA73_00635) 158568..159287 + 720 WP_004709363.1 two-component system response regulator OmpR -
KHA73_RS00645 (KHA73_00640) 159284..160654 + 1371 WP_234587438.1 two-component system sensor histidine kinase EnvZ -
KHA73_RS00650 (KHA73_00645) 160688..161167 - 480 WP_234587439.1 type II toxin-antitoxin system VapC family toxin Toxin
KHA73_RS00655 (KHA73_00650) 161164..161427 - 264 WP_234587441.1 plasmid stabilization protein Antitoxin
KHA73_RS00660 (KHA73_00655) 161553..163172 - 1620 WP_234587443.1 phosphoenolpyruvate carboxykinase (ATP) -
KHA73_RS00665 (KHA73_00660) 163369..164235 - 867 WP_234587445.1 Hsp33 family molecular chaperone HslO -
KHA73_RS00670 (KHA73_00665) 164261..164668 - 408 WP_234587446.1 ribosome-associated heat shock protein Hsp15 -
KHA73_RS00675 (KHA73_00670) 164665..165345 - 681 WP_234587448.1 GMP/IMP nucleotidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 160 a.a.        Molecular weight: 17990.69 Da        Isoelectric Point: 5.6173

>T215039 WP_234587439.1 NZ_CP082787:c161167-160688 [Serratia entomophila]
MIILDTNVMSETLRPSPHYNVINWLNEKDNDELYLSAIVIAELFSGVACMPDGKRQRDLKLKLADAIQLKFEGQILPFDG
LCAMQYAELTGRNRLQGKLMSMPDTQIAATCLHYGATLATRNTQDFLHCGIELIDPWQAPTGRRLHEDAAEYYVMSRKS

Download         Length: 480 bp

>T215039 NZ_CP110373:c82984-81641 [Proteus mirabilis]
ATGAAAGCTCAAATACTATCTGTTGCTATGAATGGTGATTTGGTTGGTAAACTAACCAAAAATACTGATGGTGGGATGTC
ATTTCAATACGCAGAAGAATGGTTGGCTGAACCAGGAGCGCGGGCAATCTCATTATCACTTCCTTTGCAAAAGGGGCGCA
TAATCGGTAGCGCAGTTTACAATTTCTTCAGCAACCTTTTACCTGATTCTGAGGCAATTATTGATAGAATGCAGATTCGT
TTTAAGGTAAAAACAAACCATCCTTTTGATCTGCTAGCCGCTGTAGGTCGTGACTGTGTTGGCGCAATCCAATTATATTC
TCCTGATACTGAAATTCCATCGGTGATGGAAACCCATGCTGAACCTTTAAATGAAAATCAAATCGAAGAGCTTTTAGACG
GTTATCAAACCGCCCCCCTTGGAATGTCCGAGGATGTAGACTTTCGGATCTCCCTTGCAGGGGCTCAAGAGAAAACAGCA
TTACTTTGGTATCAAGACTGTTGGCAGCGACCACAAGGCAGTACCCCGACAAGTCATATTTTCAAATTACCCATAGGTCT
GATTGAACACCATAATATTGATCTGCGCGAAAGCTGTGAAAACGAATGGCTATGCTTGTGTATAGCAAGAGAATTTGGAT
TTCCAGTCACCAACGCTGAATTGGCAATATTCGGTCAGAAAAAGGTACTGATCGTAGAGCGTTTTGACCGAAAATGGTCC
TCATCTGGGAACTGGCTGTTGCGCCTTCCCCAAGAGGATTGCTGTCAGGCTTTGAGTGTTGCCCCTGCATTAAAATATGA
ATCTGATGGTGGTCCAGGCATTGAATCTATCATGACGTTGCTTTTGGGCTCACAAAAAGCCATCGACGATAGAGAAATGT
TTTTTAAATCACAAATTCTGTTCTGGATGCTGGCCGCTATAGATGGGCATGGGAAAAACTTTTCCATCTTCATTGAATCT
GGGACATCTTTTCGTTTAACGCCCTTGTATGATGTTATGTCTGCTTTCCCAATTTTTGAAGCACGAGGAATTGAGATAAA
AAAGGCCAAAATGGCTATGGCATTACAAGGAAAAAACAGACAATACAATTTTTCCATGATACAACCTCGTCATTTTATCT
CTACCGCTACAAAGGTCGGGTTTCCAACAAAAACCGCAATGGAGCTAATGATTGATATGGCCGAAAAGACTGATGCAGTT
ATAGCTACCGTATCATCTCAACTGCCTGCGGACTTTCCTGAGCATATCAGTAACGCCATATTTAGTGGGTTATCAATACA
AGCCGATAAGATTAAAAGATGGTCTTCAGGAACGAGCTCACAAAATATGATGGTTTCGAATTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9785.17 Da        Isoelectric Point: 5.1200

>AT215039 WP_234587441.1 NZ_CP082787:c161427-161164 [Serratia entomophila]
MATITVRNLDDEIKELLRISAAKNGHSMEEEARMILKQALVKKPPRYGLGTWMHQHFAEFGGVELDIPPRDAVPPRIVSF
DDEDGNA

Download         Length: 264 bp

>AT215039 NZ_CP110373:c83239-82988 [Proteus mirabilis]
ATGAAAATTACAACGCCATCAATGTTAGCCGCTGCAATACATGACTTGCGCAAACAAAGTAAATTAACCCAAGCTCAAAC
GGCTGAACAAGTCGGTCTCAGGCAAGCAACTGTCTCTGAATTTGAGAACAACCCAGAATCAACAAAACTCGAAACGCTTT
TTAAAATCCTTGCCTCTTTGGAACTGGAACTACATGTAGTGAAGCGAGGAAAAAACCTGAGTGAGGGTAAGGTTTGGAAT
AAGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References