Detailed information of TA system TA021503

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): toxTA/Tad-HTH_37
• Location: 3855602..3856265
• Replicon: chromosome
• Accession: NC_007907
• Organism: Desulfitobacterium hafniense Y51

Toxin (Protein)

• Gene name: toxT
• Uniprot ID: Q24S02
• Locus tag: DSY_RS18115
• Protein ID: WP_011461083.1
• Coordinates: 3855906..3856265 (-)
• Length: 120 a.a.

Antitoxin (Protein)

• Gene name: toxA
• Uniprot ID: -
• Locus tag: DSY_RS18110
• Protein ID: WP_005815811.1
• Coordinates: 3855602..3855898 (-)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DSY_RS18085	3850789..3851556	-	768	WP_011461079.1	ABC transporter ATP-binding protein	-
DSY_RS18090	3851716..3852384	-	669	WP_041272548.1	ATP-binding cassette domain-containing protein	-
DSY_RS18095	3852384..3853076	-	693	WP_005815806.1	molybdate ABC transporter permease subunit	-
DSY_RS18100	3853236..3854075	-	840	WP_011461081.1	molybdate ABC transporter substrate-binding protein	-
DSY_RS18105	3854458..3855465	+	1008	WP_011461082.1	helix-turn-helix transcriptional regulator	-
DSY_RS18110	3855602..3855898	-	297	WP_005815811.1	helix-turn-helix transcriptional regulator	Antitoxin
DSY_RS18115	3855906..3856265	-	360	WP_011461083.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DSY_RS18120	3856474..3857709	-	1236	WP_011461084.1	LL-diaminopimelate aminotransferase	-
DSY_RS18125	3858112..3860613	-	2502	WP_041272549.1	diguanylate cyclase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (18-111)

Antitoxin

• Cro/C1-type helix-turn-helix domain (31-85)

Sequences

Toxin

Protein

• Length: 120 a.a.
• Molecular weight: 14026.20 Da
• Isoelectric Point: 9.5218

>T21503 WP_011461083.1 NC_007907:c3856265-3855906 [Desulfitobacterium hafniense Y51]
MFQIEFYNDAQGNSPIEDFLDKLDKKAATSKANRVRLKKIYEYLDILEKLGPIGEPYTKHLDGKIWELRPYSDRILFAGL
IDGKFILLHHFVKKTNKTPRREIEKALTNLEDYIQRAKE

Nucleotide

• Length: 360 bp

>T21503 NC_007907:c3856265-3855906 [Desulfitobacterium hafniense Y51]
ATGTTTCAAATTGAATTTTATAATGATGCTCAAGGCAATTCACCAATTGAAGATTTTTTAGATAAACTGGATAAGAAAGC
GGCAACCAGCAAGGCAAACCGAGTCCGGCTTAAAAAGATTTATGAGTATTTGGACATTCTGGAGAAACTAGGGCCAATCG
GCGAGCCCTATACAAAACATTTGGACGGGAAGATATGGGAACTTAGACCATATAGTGATAGAATTTTATTTGCAGGCTTG
ATAGACGGCAAATTTATTCTTCTTCATCATTTTGTTAAGAAAACCAATAAAACACCAAGACGGGAAATCGAAAAGGCACT
TACAAACTTAGAAGATTATATTCAAAGGGCAAAGGAGTGA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11105.85 Da
• Isoelectric Point: 8.4935

>AT21503 WP_005815811.1 NC_007907:c3855898-3855602 [Desulfitobacterium hafniense Y51]
MAKTWNDYKKNIKSLTAEEKAEIDLKVKIVSQIVEARKEKGLSQTELEAISGIKQTHIARLENNRNDPQLTTILKLLYPL
GMTLDVVPIVPFDTNQSQ

Nucleotide

• Length: 297 bp

>AT21503 NC_007907:c3855898-3855602 [Desulfitobacterium hafniense Y51]
ATGGCAAAAACCTGGAATGATTACAAAAAAAATATAAAATCCTTAACAGCAGAAGAAAAAGCTGAAATTGATTTGAAAGT
TAAAATCGTTAGCCAAATTGTAGAAGCCAGAAAAGAAAAAGGATTGAGTCAGACTGAACTGGAAGCAATCAGCGGAATTA
AGCAAACTCATATAGCCCGGCTTGAAAATAACCGCAATGACCCTCAGCTAACAACCATTTTAAAGCTGCTGTACCCATTG
GGAATGACACTGGATGTTGTCCCTATCGTCCCCTTCGACACAAACCAATCCCAATAA

Structures

Toxin

• AlphaFold DB: Q24S02