Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 781882..782539 Replicon chromosome
Accession NZ_CP082785
Organism Klebsiella quasipneumoniae strain MMCC7

Toxin (Protein)


Gene name cptA Uniprot ID A0A2A5MNX1
Locus tag K7176_RS03875 Protein ID WP_004205323.1
Coordinates 782129..782539 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag K7176_RS03870 Protein ID WP_002916312.1
Coordinates 781882..782148 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K7176_RS03845 (777039) 777039..778472 - 1434 WP_223079458.1 6-phospho-beta-glucosidase BglA -
K7176_RS03850 (778591) 778591..779319 - 729 WP_004205316.1 MurR/RpiR family transcriptional regulator -
K7176_RS03855 (779369) 779369..779680 + 312 WP_135699228.1 N(4)-acetylcytidine aminohydrolase -
K7176_RS03860 (779843) 779843..780502 + 660 WP_053809968.1 hemolysin III family protein -
K7176_RS03865 (780653) 780653..781636 - 984 WP_017899798.1 tRNA-modifying protein YgfZ -
K7176_RS03870 (781882) 781882..782148 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
K7176_RS03875 (782129) 782129..782539 + 411 WP_004205323.1 protein YgfX Toxin
K7176_RS03880 (782546) 782546..783067 - 522 WP_109938288.1 flavodoxin FldB -
K7176_RS03885 (783168) 783168..784064 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
K7176_RS03890 (784087) 784087..784800 + 714 WP_004205326.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
K7176_RS03895 (784806) 784806..786539 + 1734 WP_004205327.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16035.83 Da        Isoelectric Point: 11.4778

>T215025 WP_004205323.1 NZ_CP082785:782129-782539 [Klebsiella quasipneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
DWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T215025 NZ_CP110369:c5291476-5291093 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT215025 WP_002916312.1 NZ_CP082785:781882-782148 [Klebsiella quasipneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT215025 NZ_CP110369:c5291718-5291476 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A5MNX1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References