Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 3802211..3802833 Replicon chromosome
Accession NZ_CP082781
Organism Microbacterium resistens strain MZT7

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag K8F61_RS17950 Protein ID WP_231820152.1
Coordinates 3802426..3802833 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag K8F61_RS17945 Protein ID WP_067242273.1
Coordinates 3802211..3802429 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8F61_RS17920 (K8F61_17920) 3798101..3798496 - 396 WP_231820149.1 type II toxin-antitoxin system VapC family toxin -
K8F61_RS17925 (K8F61_17925) 3798493..3798768 - 276 WP_231820150.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
K8F61_RS17930 (K8F61_17930) 3798856..3799422 + 567 WP_067242267.1 DUF3817 domain-containing protein -
K8F61_RS17935 (K8F61_17935) 3799419..3801023 + 1605 WP_067242270.1 glutamine-hydrolyzing GMP synthase -
K8F61_RS17940 (K8F61_17940) 3801150..3802103 + 954 WP_231820151.1 L-lactate dehydrogenase -
K8F61_RS17945 (K8F61_17945) 3802211..3802429 + 219 WP_067242273.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
K8F61_RS17950 (K8F61_17950) 3802426..3802833 + 408 WP_231820152.1 PIN domain nuclease Toxin
K8F61_RS17955 (K8F61_17955) 3802870..3803541 - 672 WP_231820153.1 DNA alkylation repair protein -
K8F61_RS17960 (K8F61_17960) 3803751..3804176 + 426 WP_067242282.1 YciI family protein -
K8F61_RS17965 (K8F61_17965) 3804187..3805479 + 1293 WP_231820154.1 RNA polymerase sigma factor -
K8F61_RS17970 (K8F61_17970) 3805549..3806472 - 924 WP_067242288.1 Bax inhibitor-1/YccA family protein -
K8F61_RS17975 (K8F61_17975) 3806531..3807568 + 1038 WP_231820155.1 glycerophosphodiester phosphodiesterase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-117)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-39)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14845.08 Da        Isoelectric Point: 4.7540

>T215024 WP_231820152.1 NZ_CP082781:3802426-3802833 [Microbacterium resistens]
VILVDSSVWIDYLRDAPVPVVDELEDLIRSGADIRITEPVIMELLAGSSRNGDAVESLVNGLPLLRTDSMVDFRAAGELF
RASRRNGRPIRSLVDCLIAAIAIRHDAALLHKDRDFAFLAEISPLRLHPSVPPPD

Download         Length: 408 bp

>T215024 NZ_CP110369:c4974038-4973121 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGCGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8237.41 Da        Isoelectric Point: 4.5310

>AT215024 WP_067242273.1 NZ_CP082781:3802211-3802429 [Microbacterium resistens]
MTRTNIDIDDDLVKEVMGRYNLSTKKEAVNFALRRLVGVPLTKDFLLSLRGTGWDGDLDEMRDDPPVIWDKA

Download         Length: 219 bp

>AT215024 NZ_CP110369:c4974802-4974044 [Klebsiella pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGGCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGAGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References