Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 40685..41324 Replicon chromosome
Accession NZ_CP082780
Organism Bacillus aquiflavi strain 3H-10

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag K6959_RS00230 Protein ID WP_163241413.1
Coordinates 40974..41324 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag K6959_RS00225 Protein ID WP_163241415.1
Coordinates 40685..40969 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6959_RS00205 (K6959_00205) 36744..37328 - 585 WP_223087311.1 rhomboid family intramembrane serine protease -
K6959_RS00210 (K6959_00210) 37474..37830 + 357 WP_163241421.1 holo-ACP synthase -
K6959_RS00215 (K6959_00215) 38059..39090 + 1032 WP_163241419.1 outer membrane lipoprotein carrier protein LolA -
K6959_RS00220 (K6959_00220) 39363..40530 + 1168 Protein_43 alanine racemase -
K6959_RS00225 (K6959_00225) 40685..40969 + 285 WP_163241415.1 antitoxin endoai Antitoxin
K6959_RS00230 (K6959_00230) 40974..41324 + 351 WP_163241413.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
K6959_RS00235 (K6959_00235) 42058..42459 + 402 WP_163241411.1 anti-sigma regulatory factor -
K6959_RS00240 (K6959_00240) 42473..43483 + 1011 WP_223087312.1 PP2C family protein-serine/threonine phosphatase -
K6959_RS00245 (K6959_00245) 43542..43877 + 336 WP_163241407.1 anti-sigma factor antagonist -
K6959_RS00250 (K6959_00250) 43874..44353 + 480 WP_163241405.1 anti-sigma B factor RsbW -
K6959_RS00255 (K6959_00255) 44331..45122 + 792 WP_163241403.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13035.03 Da        Isoelectric Point: 4.8998

>T215022 WP_163241413.1 NZ_CP082780:40974-41324 [Bacillus aquiflavi]
MNIKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIIAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVDEALQVSLGLIEF

Download         Length: 351 bp

>T215022 NZ_CP110369:c4631413-4630880 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGTATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10842.29 Da        Isoelectric Point: 7.2015

>AT215022 WP_163241415.1 NZ_CP082780:40685-40969 [Bacillus aquiflavi]
VSESSTATTEILVKLPQHLLSELDGYVKQENGNRSDFIYQATKMYLRERKKRQIREAMRRGYMEMAKINLTIASEAFQAE
YEAEHTVERLVSGG

Download         Length: 285 bp

>AT215022 NZ_CP110369:c4631690-4631424 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References