Detailed information of TA system TA215021

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/-
• Location: 1957758..1958283
• Replicon: chromosome
• Accession: NZ_CP082778
• Organism: Streptococcus suis strain ID32098

Toxin (Protein)

• Gene name: parE
• Uniprot ID: G7SEL6
• Locus tag: JSY00_RS09440
• Protein ID: WP_014638724.1
• Coordinates: 1957758..1958087 (-)
• Length: 110 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: JSY00_RS09445
• Protein ID: WP_238492611.1
• Coordinates: 1958077..1958283 (-)
• Length: 69 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JSY00_RS09420 (JSY00_09420)	1953108..1954838	-	1731	WP_041179291.1	membrane protein	-
JSY00_RS09425 (JSY00_09425)	1955041..1955913	-	873	WP_014638721.1	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA	-
JSY00_RS09430 (JSY00_09430)	1956091..1957260	-	1170	WP_014638722.1	hypothetical protein	-
JSY00_RS09435 (JSY00_09435)	1957277..1957660	-	384	WP_014638723.1	DUF2513 domain-containing protein	-
JSY00_RS09440 (JSY00_09440)	1957758..1958087	-	330	WP_014638724.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JSY00_RS09445 (JSY00_09445)	1958077..1958283	-	207	WP_238492611.1	toxin-antitoxin system antitoxin subunit	Antitoxin
JSY00_RS09450 (JSY00_09450)	1958462..1958830	-	369	WP_024401195.1	hypothetical protein	-
JSY00_RS09455 (JSY00_09455)	1958823..1959392	-	570	WP_105105440.1	ribonuclease M5	-
JSY00_RS09460 (JSY00_09460)	1959376..1960158	-	783	WP_105105439.1	TatD family hydrolase	-
JSY00_RS09465 (JSY00_09465)	1960265..1960402	-	138	WP_002939016.1	50S ribosomal protein L34	-
JSY00_RS09470 (JSY00_09470)	1960570..1961565	-	996	WP_024395756.1	RNA-binding cell elongation regulator Jag/EloR	-
JSY00_RS09475 (JSY00_09475)	1961585..1962397	-	813	WP_202847568.1	YidC/Oxa1 family membrane protein insertase	-
JSY00_RS09480 (JSY00_09480)	1962381..1962740	-	360	WP_004194560.1	ribonuclease P protein component	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-96)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 110 a.a.
• Molecular weight: 12607.51 Da
• Isoelectric Point: 5.7640

>T215021 WP_014638724.1 NZ_CP082778:c1958087-1957758 [Streptococcus suis]
MEFESYSVILAPAVEKELADIYAYFSEQFSEEIAKRRIGMIVEALESLQIFPERGFNADNRFGKQIDPPHLTRGYVIGKD
YIALYRVVEKEVRVGHLFATKSDYVKLLK

Nucleotide

• Length: 330 bp

>T215021 NZ_CP110369:4036004-4036222 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin

Protein

• Length: 69 a.a.
• Molecular weight: 7816.90 Da
• Isoelectric Point: 3.9249

>AT215021 WP_238492611.1 NZ_CP082778:c1958283-1958077 [Streptococcus suis]
MNQLDLTAGFNLFLQNIAVKNELPILTEEELEREELFLQLQKEIQENQQAIEAGQGISLEIVKEKYGI

Nucleotide

• Length: 207 bp

>AT215021 NZ_CP110369:4035603-4035977 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Structures

Toxin

• AlphaFold DB: G7SEL6