Detailed information of TA system TA215020

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1486057..1486705
• Replicon: chromosome
• Accession: NZ_CP082778
• Organism: Streptococcus suis strain ID32098

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: JSY00_RS07280
• Protein ID: WP_044679833.1
• Coordinates: 1486544..1486705 (-)
• Length: 54 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: G7SGM2
• Locus tag: JSY00_RS07275
• Protein ID: WP_014637654.1
• Coordinates: 1486057..1486506 (-)
• Length: 150 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JSY00_RS07260 (JSY00_07260)	1481715..1483646	-	1932	WP_202847630.1	C69 family dipeptidase	-
JSY00_RS07265 (JSY00_07265)	1483839..1484699	-	861	WP_044762617.1	SAM-dependent methyltransferase TehB	-
JSY00_RS07270 (JSY00_07270)	1484853..1485896	+	1044	WP_202847719.1	alcohol dehydrogenase catalytic domain-containing protein	-
JSY00_RS07275 (JSY00_07275)	1486057..1486506	-	450	WP_014637654.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
JSY00_RS07280 (JSY00_07280)	1486544..1486705	-	162	WP_044679833.1	type II toxin-antitoxin system HicA family toxin	Toxin
JSY00_RS07285 (JSY00_07285)	1487092..1487310	-	219	WP_228475258.1	hypothetical protein	-
JSY00_RS07290 (JSY00_07290)	1487621..1488478	-	858	WP_052502457.1	ABC transporter ATP-binding protein	-
JSY00_RS07295 (JSY00_07295)	1488480..1489163	-	684	WP_044679832.1	hypothetical protein	-
JSY00_RS07300 (JSY00_07300)	1489566..1490033	-	468	WP_014637647.1	SsrA-binding protein SmpB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (1-52)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (17-114)

Sequences

Toxin

Protein

• Length: 54 a.a.
• Molecular weight: 5807.85 Da
• Isoelectric Point: 10.9132

>T215020 WP_044679833.1 NZ_CP082778:c1486705-1486544 [Streptococcus suis]
MVKLLTAHGWTKTKGGKGSHVKLEKAGERPITIPHGEINKYTERGIKKQAGLL

Nucleotide

• Length: 162 bp

>T215020 NZ_CP110369:c3904638-3904321 [Klebsiella pneumoniae]
ATGTTCAGATTGGTTGTGCATGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGCCCATTGTCCAGGCGAAGATGATCCG
GCAATTAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGACAGTAAACCGCTGGGGCAGGGGCTATTTGAAA
TTCGTGCGTTAGGTTCGGTACAGGGGCGAGGGATCTACGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA

Antitoxin

Protein

• Length: 150 a.a.
• Molecular weight: 16664.69 Da
• Isoelectric Point: 3.9458

>AT215020 WP_014637654.1 NZ_CP082778:c1486506-1486057 [Streptococcus suis]
MLVTYPALFYFDDTDGANAPYFVTFPDFEYSATQGEDMADAMAMASDWLGMNLADYIENGRDIPTPSSINTLSLVDNNPF
RNEDFEMVYDSSKSFISMVMVDVAKYLGSQEPVKKTLTIPRWADTLGRELGLNFSQTLTDAIADKKIHA

Nucleotide

• Length: 450 bp

>AT215020 NZ_CP110369:c3904328-3904041 [Klebsiella pneumoniae]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTGGCCAGCCTGAGGTTCAGGCTGCATTCGATGC
GCAAGAACGTCAACAGCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTAACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCGACAGTCTCCAGAATGGAAGCCAATATCACCCGCGCCAGTCTGGATACCTTAACGCGA
TACGCGTTAGCCTGCGGTATAAAGCACCCGCAAGTTTTACTTTACTAA

Structures

Antitoxin

• AlphaFold DB: G7SGM2