Detailed information of TA system TA215018

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): omega-epsilon-zeta/zeta-couple_hipB
• Location: 1172696..1173939
• Replicon: chromosome
• Accession: NZ_CP082778
• Organism: Streptococcus suis strain ID32098

Toxin (Protein)

• Gene name: sezT
• Uniprot ID: G7SEB4
• Locus tag: JSY00_RS05800
• Protein ID: WP_001235242.1
• Coordinates: 1172696..1173463 (-)
• Length: 256 a.a.

Antitoxin (Protein)

• Gene name: sezA
• Uniprot ID: -
• Locus tag: JSY00_RS05805
• Protein ID: WP_000578719.1
• Coordinates: 1173463..1173939 (-)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JSY00_RS05785 (JSY00_05785)	1169084..1169449	-	366	WP_000431640.1	MobC family plasmid mobilization relaxosome protein	-
JSY00_RS05790 (JSY00_05790)	1169452..1169814	-	363	WP_000140674.1	SAG1252 family conjugative relaxosome accessory protein	-
JSY00_RS05795 (JSY00_05795)	1170152..1172695	-	2544	WP_000601012.1	AAA family ATPase	-
JSY00_RS05800 (JSY00_05800)	1172696..1173463	-	768	WP_001235242.1	type II toxin-antitoxin system toxin PezT	Toxin
JSY00_RS05805 (JSY00_05805)	1173463..1173939	-	477	WP_000578719.1	type II toxin-antitoxin system antitoxin PezA	Antitoxin
JSY00_RS05810 (JSY00_05810)	1174009..1174299	-	291	WP_000667951.1	hypothetical protein	-
JSY00_RS05815 (JSY00_05815)	1174349..1174738	-	390	WP_044475264.1	DUF5945 family protein	-
JSY00_RS05820 (JSY00_05820)	1174735..1174962	-	228	WP_000110922.1	DUF5965 family protein	-
JSY00_RS05825 (JSY00_05825)	1174990..1176090	-	1101	WP_014636297.1	toprim domain-containing protein	-
JSY00_RS05830 (JSY00_05830)	1176130..1176768	-	639	WP_014636296.1	hypothetical protein	-
JSY00_RS05835 (JSY00_05835)	1176863..1177153	-	291	WP_000893083.1	DUF5966 family protein	-
JSY00_RS05840 (JSY00_05840)	1177167..1177466	-	300	WP_014636295.1	DUF5962 family protein	-
JSY00_RS05845 (JSY00_05845)	1177537..1178496	-	960	Protein_1111	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	tet(O) / erm(B)	-	1074575..1319526	244951

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (28-214)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 256 a.a.
• Molecular weight: 28985.80 Da
• Isoelectric Point: 5.1126

>T215018 WP_001235242.1 NZ_CP082778:c1173463-1172696 [Streptococcus suis]
MRLEEFSEAEFQKALQRTIRALTRGKTIPDQPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFAGKMVEQLVDELSTQGYHLLIEGTLRTTQVPRQTAQLLSSKGYQVSLAVIGTKPELSYLSTLIRYEE
LYAIDPTQARATPKEHHDGIVENLVDNLRELESENLFDQIQIYQRDRTCIYDSETAEGSAAEVLQECLFGKWSKVEEEMV
KESELLLKELLEKNK

Nucleotide

• Length: 768 bp

>T215018 NZ_CP110369:1864350-1864452 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18266.77 Da
• Isoelectric Point: 4.6424

>AT215018 WP_000578719.1 NZ_CP082778:c1173939-1173463 [Streptococcus suis]
MIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLTPVEDYHLTLKVE
VIKERGAAILSKLYRYQDSQDIVFDDESNPWILMSDDLAELINTKIYLVATFDEIERYNGYLDGIERMLDMVHHRVVA

Nucleotide

• Length: 477 bp

>AT215018 NZ_CP110369:c1864459-1864314 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Structures

Toxin

• AlphaFold DB: G7SEB4