215017

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 975170..975671 Replicon chromosome
Accession NZ_CP082778
Organism Streptococcus suis strain ID32098

Toxin (Protein)


Gene name relE Uniprot ID G7SDZ6
Locus tag JSY00_RS04890 Protein ID WP_014637925.1
Coordinates 975405..975671 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A116L3F7
Locus tag JSY00_RS04885 Protein ID WP_024385716.1
Coordinates 975170..975421 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JSY00_RS04860 (JSY00_04860) 970497..971663 + 1167 WP_202847705.1 ATP-grasp domain-containing protein -
JSY00_RS04865 (JSY00_04865) 971804..971944 + 141 WP_044683303.1 hypothetical protein -
JSY00_RS04870 (JSY00_04870) 971957..972328 + 372 WP_202847704.1 NisI/SpaI family lantibiotic immunity lipoprotein -
JSY00_RS04875 (JSY00_04875) 972356..973108 + 753 WP_015646831.1 ATP-binding cassette domain-containing protein -
JSY00_RS04880 (JSY00_04880) 973109..975079 + 1971 WP_202847703.1 ABC transporter permease -
JSY00_RS04885 (JSY00_04885) 975170..975421 + 252 WP_024385716.1 DUF6290 family protein Antitoxin
JSY00_RS04890 (JSY00_04890) 975405..975671 + 267 WP_014637925.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JSY00_RS04895 (JSY00_04895) 975710..976378 + 669 WP_024413648.1 response regulator transcription factor -
JSY00_RS04900 (JSY00_04900) 976375..977316 + 942 WP_024413647.1 sensor histidine kinase -
JSY00_RS04905 (JSY00_04905) 977497..979005 + 1509 WP_202847702.1 phosphomannomutase/phosphoglucomutase -
JSY00_RS04910 (JSY00_04910) 979068..980138 - 1071 WP_044769194.1 tyrosine recombinase XerS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(10-87)

Antitoxin

Protein of unknown function DUF6290

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10345.99 Da        Isoelectric Point: 10.7260

>T215017 WP_014637925.1 NZ_CP082778:975405-975671 [Streptococcus suis]
MKTSYKLVPTGRFIKQLKKLDKFTQKQITNYLSSHVTDNPRQYGKALTANRSGQWRYRIGNYRVIVSIEDDKLIVTALEV
GHRKEIYK

Download         Length: 267 bp

>T215017 NZ_CP110369:1772986-1773318 [Klebsiella pneumoniae]
ATGGACAGAGGGGAAATCTGGCTTGTTTCACTGGATCCGATTGCTGGCCACGAGCAAAGTGGAAAACGTCCGGTACTCAT
TGTATCGAAGGCATCGTTTAACAAGCTGACCCGACTACCGGTCGTGGTTCCCGTCACCAGCGGCGGAAACTTTGCACGTA
CAGCAGGTTTCACGGTTTCACTGGAAGAGGCGGGGACCAAAACAACAGGCGTTATTCGCTGCGACCAGCCCAGGACTATC
GATATGGCGGCCCGGAAAGGCAAGCGTCTGGAACGCATACCTGACGTCGTTGTCAACGAGGTGCTTGCCAGGCTGGATGC
GATGCTGAGTTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9296.46 Da        Isoelectric Point: 3.6675

>AT215017 WP_024385716.1 NZ_CP082778:975170-975421 [Streptococcus suis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADIALAEYEADLANGIEPISWEEMLEDLGLTDE
DQL

Download         Length: 252 bp

>AT215017 NZ_CP110369:1772728-1772985 [Klebsiella pneumoniae]
ATGTATACAACTCGCCTGAAAAAGGTCGGCGGATCCATCATGCTGGCGGTTCCTCCCGCCGTGCTGAAAACGCTGGAGCT
GTCGACGGACAGCGAAGTGGGTATGACCATTGATAATGGCTGCCTGATTATTGAACCCCAGAAACGGCCCCGTTATTCGC
TTGAGGAGCTGCTGGCGCAGTGCGATCCGCACGCCGAAATGAGCGAAGAGGATCGGGAATGGATTGATGCGCCTGCGGTG
GGCAAGGAGATTCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G7SDZ6

Antitoxin

Source ID Structure
AlphaFold DB A0A116L3F7

References