Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 4226008..4226842 | Replicon | chromosome |
| Accession | NZ_CP082777 | ||
| Organism | Escherichia coli O25:H1 strain CU39ES-1 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | S1PLF5 |
| Locus tag | K8B91_RS20265 | Protein ID | WP_000854690.1 |
| Coordinates | 4226465..4226842 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | S1P7N8 |
| Locus tag | K8B91_RS20260 | Protein ID | WP_001305076.1 |
| Coordinates | 4226008..4226376 (+) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K8B91_RS20220 (4221090) | 4221090..4222217 | + | 1128 | Protein_3945 | hypothetical protein | - |
| K8B91_RS20225 (4222293) | 4222293..4222748 | + | 456 | WP_000581502.1 | IrmA family protein | - |
| K8B91_RS20230 (4222827) | 4222827..4223060 | + | 234 | WP_000902034.1 | DUF905 family protein | - |
| K8B91_RS20235 (4223161) | 4223161..4223979 | + | 819 | WP_001234620.1 | DUF932 domain-containing protein | - |
| K8B91_RS20240 (4224034) | 4224034..4224519 | + | 486 | WP_000849565.1 | antirestriction protein | - |
| K8B91_RS20245 (4224535) | 4224535..4225011 | + | 477 | WP_001186726.1 | RadC family protein | - |
| K8B91_RS20250 (4225074) | 4225074..4225295 | + | 222 | WP_000692329.1 | DUF987 domain-containing protein | - |
| K8B91_RS20255 (4225314) | 4225314..4225958 | + | 645 | WP_000094916.1 | hypothetical protein | - |
| K8B91_RS20260 (4226008) | 4226008..4226376 | + | 369 | WP_001305076.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| K8B91_RS20265 (4226465) | 4226465..4226842 | + | 378 | WP_000854690.1 | TA system toxin CbtA family protein | Toxin |
| K8B91_RS20270 (4226839) | 4226839..4227327 | + | 489 | WP_000761699.1 | DUF5983 family protein | - |
| K8B91_RS20275 (4227344) | 4227344..4227541 | + | 198 | WP_000839293.1 | DUF957 domain-containing protein | - |
| K8B91_RS20280 (4227626) | 4227626..4228471 | + | 846 | WP_001529401.1 | DUF4942 domain-containing protein | - |
| K8B91_RS20285 (4228540) | 4228540..4228935 | + | 396 | WP_000208382.1 | DUF6088 family protein | - |
| K8B91_RS20290 (4228928) | 4228928..4229861 | + | 934 | Protein_3959 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | - |
| K8B91_RS20295 (4230278) | 4230278..4230448 | + | 171 | Protein_3960 | IS110 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14057.04 Da Isoelectric Point: 9.1510
>T215015 WP_000854690.1 NZ_CP082777:4226465-4226842 [Escherichia coli O25:H1]
MKTLPDTHVRAASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYAQVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR
MKTLPDTHVRAASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYAQVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR
Download Length: 378 bp
>T215015 NZ_CP110369:324086-324454 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13560.39 Da Isoelectric Point: 4.7830
>AT215015 WP_001305076.1 NZ_CP082777:4226008-4226376 [Escherichia coli O25:H1]
MSDTLPGTTLPDDNKDLPWWGLPCTVTPCFGACLVQEGNRLHYLADRAGIRGRFSDADAYHPDQAFPLLMKQPELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCDYVYLAVYPTPEMKN
MSDTLPGTTLPDDNKDLPWWGLPCTVTPCFGACLVQEGNRLHYLADRAGIRGRFSDADAYHPDQAFPLLMKQPELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCDYVYLAVYPTPEMKN
Download Length: 369 bp
>AT215015 NZ_CP110369:323868-324089 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|