Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 23724..24262 Replicon chromosome
Accession NC_007802
Organism Jannaschia sp. CCS1

Toxin (Protein)


Gene name parE Uniprot ID Q28WH1
Locus tag JANN_RS00130 Protein ID WP_011453150.1
Coordinates 23724..24008 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q28WH0
Locus tag JANN_RS00135 Protein ID WP_011453151.1
Coordinates 24005..24262 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JANN_RS00110 19046..20602 - 1557 WP_011453146.1 alanine:cation symporter family protein -
JANN_RS00115 20615..21046 - 432 WP_011453147.1 universal stress protein -
JANN_RS00120 21276..22568 + 1293 WP_011453148.1 nicotinate phosphoribosyltransferase -
JANN_RS00125 22565..23512 - 948 WP_044006172.1 hypothetical protein -
JANN_RS00130 23724..24008 - 285 WP_011453150.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JANN_RS00135 24005..24262 - 258 WP_011453151.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
JANN_RS00140 24321..24740 - 420 WP_011453152.1 aminoacyl-tRNA hydrolase -
JANN_RS00145 25037..25654 - 618 WP_044006173.1 queuosine precursor transporter -
JANN_RS00150 25771..26955 - 1185 WP_044006174.1 aspartate/tyrosine/aromatic aminotransferase -
JANN_RS00155 26948..27508 - 561 WP_011453155.1 GNAT family N-acetyltransferase -
JANN_RS00160 27505..28368 - 864 WP_011453156.1 3-mercaptopyruvate sulfurtransferase -
JANN_RS00165 28499..28975 - 477 WP_011453157.1 SsrA-binding protein SmpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-91)

Antitoxin

Antitoxin ParD

(4-72)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10391.76 Da        Isoelectric Point: 5.6142

>T21499 WP_011453150.1 NC_007802:c24008-23724 [Jannaschia sp. CCS1]
VKELVIAPRADADLIGIYDYTSDTWGLDQADKYLDELHGRISGLVTGATVSRSAEEVGPGLRRALAGQHVVFFREDAETV
KVVRVLHQRMDLGR

Download         Length: 285 bp

>T21499 NC_007802:c24008-23724 [Jannaschia sp. CCS1]
GTGAAAGAGCTTGTCATTGCGCCGCGCGCGGATGCCGACCTGATCGGCATCTATGACTACACGTCGGATACATGGGGCCT
CGACCAGGCAGATAAATATCTAGATGAATTGCACGGACGGATCAGCGGGTTGGTGACCGGAGCGACGGTTTCGCGAAGCG
CGGAGGAGGTCGGGCCGGGCCTGCGCCGCGCTTTGGCGGGGCAGCATGTGGTGTTTTTTCGGGAGGACGCGGAGACCGTG
AAGGTGGTGCGGGTTCTGCATCAGCGGATGGATTTGGGGAGGTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9582.70 Da        Isoelectric Point: 7.3178

>AT21499 WP_011453151.1 NC_007802:c24262-24005 [Jannaschia sp. CCS1]
MARNTSVSLGDHFGEFINEKVQEGRYGSASDVIRAGLRLLEEEEAKLAHLRELIAQGDASGPGKPWNYEDWKAKRHADYA
KRRAL

Download         Length: 258 bp

>AT21499 NC_007802:c24262-24005 [Jannaschia sp. CCS1]
ATGGCGCGCAATACATCGGTCTCACTCGGGGATCACTTCGGAGAATTCATCAATGAAAAAGTGCAAGAAGGCCGCTATGG
CTCCGCCAGCGACGTGATCCGCGCAGGCCTCAGGCTTCTGGAAGAGGAAGAGGCGAAACTGGCGCATCTGCGAGAGCTGA
TCGCGCAAGGGGATGCGAGCGGGCCGGGCAAACCTTGGAATTACGAGGACTGGAAAGCCAAGCGACACGCCGACTATGCG
AAACGGCGCGCTTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q28WH1

Antitoxin

Source ID Structure
AlphaFold DB Q28WH0

References