21492

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2154696..2155210 Replicon chromosome
Accession NC_007795
Organism Staphylococcus aureus subsp. aureus NCTC 8325

Toxin (Protein)


Gene name TsdT Uniprot ID Q2FWH0
Locus tag SAOUHSC_02321 Protein ID YP_500800.1
Coordinates 2154696..2154905 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q2FWG9
Locus tag SAOUHSC_02322 Protein ID YP_500801.1
Coordinates 2154917..2155210 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAOUHSC_02317 2150204..2151562 - 1359 YP_500796.1 UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanyl ligase -
SAOUHSC_02318 2151577..2152647 - 1071 YP_500797.1 D-alanyl-alanine synthetase A -
SAOUHSC_02319 2152965..2154167 + 1203 YP_500798.1 hypothetical protein -
SAOUHSC_02320 2154431..2154568 - 138 YP_500799.1 hypothetical protein -
SAOUHSC_02321 2154696..2154905 - 210 YP_500800.1 hypothetical protein Toxin
SAOUHSC_02322 2154917..2155210 - 294 YP_500801.1 hypothetical protein Antitoxin
SAOUHSC_02323 2155376..2156860 + 1485 YP_500802.1 cardiolipin synthetase -
SAOUHSC_02324 2156888..2157535 + 648 YP_500803.1 hypothetical protein -
SAOUHSC_02325 2157595..2157702 - 108 YP_500804.1 hypothetical protein -
SAOUHSC_02326 2157710..2157802 - 93 YP_500805.1 hypothetical protein -
SAOUHSC_02327 2158348..2159220 - 873 YP_500806.1 hypothetical protein -
SAOUHSC_02328 2159306..2159947 - 642 YP_500807.1 thiamine-phosphate pyrophosphorylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T21492 YP_500800.1 NC_007795:c2154905-2154696 [Staphylococcus aureus subsp. aureus NCTC 8325]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T21492 NC_007795:c2154905-2154696 [Staphylococcus aureus subsp. aureus NCTC 8325]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT21492 YP_500801.1 NC_007795:c2155210-2154917 [Staphylococcus aureus subsp. aureus NCTC 8325]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT21492 NC_007795:c2155210-2154917 [Staphylococcus aureus subsp. aureus NCTC 8325]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB Q2FWG9

References