Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | cptAB/Cpta(toxin) |
| Location | 3900499..3901153 | Replicon | chromosome |
| Accession | NZ_CP082773 | ||
| Organism | Escherichia coli O99:H6 strain CU42ET-1 | ||
Toxin (Protein)
| Gene name | cptA | Uniprot ID | S1PAM6 |
| Locus tag | K8B87_RS18630 | Protein ID | WP_000244781.1 |
| Coordinates | 3900499..3900906 (-) | Length | 136 a.a. |
Antitoxin (Protein)
| Gene name | cptB | Uniprot ID | S1PPB1 |
| Locus tag | K8B87_RS18635 | Protein ID | WP_000354046.1 |
| Coordinates | 3900887..3901153 (-) | Length | 89 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K8B87_RS18610 (3896456) | 3896456..3898189 | - | 1734 | WP_000813189.1 | single-stranded-DNA-specific exonuclease RecJ | - |
| K8B87_RS18615 (3898195) | 3898195..3898905 | - | 711 | WP_000715230.1 | bifunctional protein-disulfide isomerase/oxidoreductase DsbC | - |
| K8B87_RS18620 (3898930) | 3898930..3899826 | - | 897 | WP_087602758.1 | site-specific tyrosine recombinase XerD | - |
| K8B87_RS18625 (3899938) | 3899938..3900459 | + | 522 | WP_001055874.1 | flavodoxin FldB | - |
| K8B87_RS18630 (3900499) | 3900499..3900906 | - | 408 | WP_000244781.1 | protein YgfX | Toxin |
| K8B87_RS18635 (3900887) | 3900887..3901153 | - | 267 | WP_000354046.1 | FAD assembly factor SdhE | Antitoxin |
| K8B87_RS18640 (3901396) | 3901396..3902376 | + | 981 | WP_001553396.1 | tRNA-modifying protein YgfZ | - |
| K8B87_RS18645 (3902453) | 3902453..3903112 | - | 660 | WP_000250274.1 | hemolysin III family protein | - |
| K8B87_RS18650 (3903276) | 3903276..3903587 | - | 312 | WP_001182956.1 | N(4)-acetylcytidine aminohydrolase | - |
| K8B87_RS18655 (3903632) | 3903632..3905065 | + | 1434 | WP_140395597.1 | 6-phospho-beta-glucosidase BglA | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 136 a.a. Molecular weight: 16061.99 Da Isoelectric Point: 11.5202
>T214911 WP_000244781.1 NZ_CP082773:c3900906-3900499 [Escherichia coli O99:H6]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR
Download Length: 408 bp
>T214911 NZ_CP110342:c2926068-2925250 [Marinobacter sp. AN1]
TTGAGCTACCTGGAGCGAATATACACCCAGACGGGGCCACTCAAGGGGCAGGTTTACCGGGTGGCGGAAACCCAGGAGAA
ATCCGCCACCACCGATATCGTCGACACCGCTGAAGAGCAGTCTCGCCTTGAAGAGCTACTGGAAGAAAGCAAGCCGCCTT
ACACGCACCCTGATCGTGGGCTGCACTACCTGTTGAAAACGCCATTTCGATATCCGCCGTTGCGTTATGGTTCTCGCTTC
GGGCGAGTCTTCGAGAAAAGCCTGTTTTACGGTTCTGCCGACACCCAAACGGCGTTGTCGGAAACCGCTTATTACCGGCT
GGTGTTCGTTCGGGACACTACAAAGCCGTTCCCCAGGCCGGTCAAATCCCACCATACAATCTTTGAAGCGTCGGTAGGGG
TGGAAAAGGGGCTCCAGCTTCAATCGTCCGCCTGGCGCGATGTTCGGGACAAGCTGACCCATCCGTCGGATTATGCGTTT
ACCCAGGCTCTGGGGGGCGAGATGCGGGAAGCTGGTGTTCAGGCGTTCCAGTTTATTTCAGCCCGGGCAGTGCAGGTGGG
GCTTCGGGCTCCCGACGCTGAAGACAGGGCTGCAGGAAAGTCCAAGTCGGGGTTGAACGCAGTGGGCCTCAACTGGGGGG
TGTTCACGCCAAAAGCCTTCCGGCGGCGTCAGCCGAGTAATTTTCGGCCGATGATTGCCGTGACCACCCGAGAGCACGTA
TCCATTGTCGTGACGGAGCGTGATGGTACCTCTACCGCCGCGGAATTCCCTGCCGACAGATTTATGGTAGCCGGGCAGCT
TCCCCGTCCCGCGGTCTGA
TTGAGCTACCTGGAGCGAATATACACCCAGACGGGGCCACTCAAGGGGCAGGTTTACCGGGTGGCGGAAACCCAGGAGAA
ATCCGCCACCACCGATATCGTCGACACCGCTGAAGAGCAGTCTCGCCTTGAAGAGCTACTGGAAGAAAGCAAGCCGCCTT
ACACGCACCCTGATCGTGGGCTGCACTACCTGTTGAAAACGCCATTTCGATATCCGCCGTTGCGTTATGGTTCTCGCTTC
GGGCGAGTCTTCGAGAAAAGCCTGTTTTACGGTTCTGCCGACACCCAAACGGCGTTGTCGGAAACCGCTTATTACCGGCT
GGTGTTCGTTCGGGACACTACAAAGCCGTTCCCCAGGCCGGTCAAATCCCACCATACAATCTTTGAAGCGTCGGTAGGGG
TGGAAAAGGGGCTCCAGCTTCAATCGTCCGCCTGGCGCGATGTTCGGGACAAGCTGACCCATCCGTCGGATTATGCGTTT
ACCCAGGCTCTGGGGGGCGAGATGCGGGAAGCTGGTGTTCAGGCGTTCCAGTTTATTTCAGCCCGGGCAGTGCAGGTGGG
GCTTCGGGCTCCCGACGCTGAAGACAGGGCTGCAGGAAAGTCCAAGTCGGGGTTGAACGCAGTGGGCCTCAACTGGGGGG
TGTTCACGCCAAAAGCCTTCCGGCGGCGTCAGCCGAGTAATTTTCGGCCGATGATTGCCGTGACCACCCGAGAGCACGTA
TCCATTGTCGTGACGGAGCGTGATGGTACCTCTACCGCCGCGGAATTCCCTGCCGACAGATTTATGGTAGCCGGGCAGCT
TCCCCGTCCCGCGGTCTGA
Antitoxin
Download Length: 89 a.a. Molecular weight: 10547.12 Da Isoelectric Point: 5.1599
>AT214911 WP_000354046.1 NZ_CP082773:c3901153-3900887 [Escherichia coli O99:H6]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI
Download Length: 267 bp
>AT214911 NZ_CP110342:c2926430-2926065 [Marinobacter sp. AN1]
ATGACCCTGGCCGCCGCCACGCAAAACCGGACCAACGATCGCACTTTGCTCGCCAAGGCGCTTTTTAATGCCGCCGATGC
CATGGGGGTTGCCAAGGCTGACGTGTCAAAGATCGTTGGACGGGATCGTACCGGCATCACTCGCGACGGCATTGATCCGC
AGTCAAAGTCCGGCGAACTGGCGCTTATGTTTGTTCGTGTATACCGGGGGCTTTATGCACTGGTCGGTGGCGACCGGGAC
AATATGCGGCACTGGCTAACCACTGATAATGAGTACTTCGGCCAGGCGCCCCTGCAGACGATGAAAACCTGCGAGGGCCT
GGTGCGGGTAGTGATGTACCTCGATGCCATCCGGGGCAAGGTTTGA
ATGACCCTGGCCGCCGCCACGCAAAACCGGACCAACGATCGCACTTTGCTCGCCAAGGCGCTTTTTAATGCCGCCGATGC
CATGGGGGTTGCCAAGGCTGACGTGTCAAAGATCGTTGGACGGGATCGTACCGGCATCACTCGCGACGGCATTGATCCGC
AGTCAAAGTCCGGCGAACTGGCGCTTATGTTTGTTCGTGTATACCGGGGGCTTTATGCACTGGTCGGTGGCGACCGGGAC
AATATGCGGCACTGGCTAACCACTGATAATGAGTACTTCGGCCAGGCGCCCCTGCAGACGATGAAAACCTGCGAGGGCCT
GGTGCGGGTAGTGATGTACCTCGATGCCATCCGGGGCAAGGTTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | S1PAM6 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U9QD57 |