Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 2957332..2958163 | Replicon | chromosome |
| Accession | NZ_CP082773 | ||
| Organism | Escherichia coli O99:H6 strain CU42ET-1 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | - |
| Locus tag | K8B87_RS14360 | Protein ID | WP_087602611.1 |
| Coordinates | 2957789..2958163 (+) | Length | 125 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | - |
| Locus tag | K8B87_RS14355 | Protein ID | WP_087602652.1 |
| Coordinates | 2957332..2957700 (+) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K8B87_RS14320 (2952386) | 2952386..2953456 | + | 1071 | WP_000102631.1 | patatin-like phospholipase family protein | - |
| K8B87_RS14325 (2953592) | 2953592..2954270 | + | 679 | Protein_2787 | hypothetical protein | - |
| K8B87_RS14330 (2954286) | 2954286..2954696 | + | 411 | WP_000846704.1 | hypothetical protein | - |
| K8B87_RS14335 (2954917) | 2954917..2955738 | + | 822 | WP_087603069.1 | DUF932 domain-containing protein | - |
| K8B87_RS14340 (2956001) | 2956001..2956471 | + | 471 | WP_234257570.1 | antirestriction protein | - |
| K8B87_RS14345 (2956487) | 2956487..2956963 | + | 477 | WP_001186786.1 | RadC family protein | - |
| K8B87_RS14350 (2957032) | 2957032..2957253 | + | 222 | WP_000692312.1 | DUF987 domain-containing protein | - |
| K8B87_RS14355 (2957332) | 2957332..2957700 | + | 369 | WP_087602652.1 | type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA | Antitoxin |
| K8B87_RS14360 (2957789) | 2957789..2958163 | + | 375 | WP_087602611.1 | type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA | Toxin |
| K8B87_RS14365 (2958160) | 2958160..2958354 | + | 195 | WP_000988600.1 | DUF5983 family protein | - |
| K8B87_RS14370 (2958400) | 2958400..2958480 | + | 81 | Protein_2796 | hypothetical protein | - |
| K8B87_RS14375 (2958769) | 2958769..2958849 | - | 81 | WP_023441679.1 | hypothetical protein | - |
| K8B87_RS14380 (2958828) | 2958828..2959151 | + | 324 | WP_223216378.1 | EutP/PduV family microcompartment system protein | - |
| K8B87_RS14385 (2959252) | 2959252..2959581 | - | 330 | WP_045177570.1 | DUF496 family protein | - |
| K8B87_RS14390 (2959753) | 2959753..2960811 | - | 1059 | WP_234257579.1 | FUSC family protein | - |
| K8B87_RS14395 (2961009) | 2961009..2961482 | - | 474 | WP_061353310.1 | DNA gyrase inhibitor SbmC | - |
| K8B87_RS14400 (2961601) | 2961601..2962767 | - | 1167 | WP_087602613.1 | serine-type D-Ala-D-Ala carboxypeptidase DacD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 13894.91 Da Isoelectric Point: 7.8793
>T214906 WP_087602611.1 NZ_CP082773:2957789-2958163 [Escherichia coli O99:H6]
MKTLPVLPGQAASSRPSPVEIWQKLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTHSQLINSIDILRARRATGLMTRDNYRAVNNITLGKYPETK
MKTLPVLPGQAASSRPSPVEIWQKLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTHSQLINSIDILRARRATGLMTRDNYRAVNNITLGKYPETK
Download Length: 375 bp
>T214906 NZ_CP110339:2193810-2194187 [Brucella sp. JSBI001]
GTGATACTAGCAGATACTTCCATTTGGATTGATCATTTCCGCCGAGGTGATAACGATCTTGTAAAAATTATTGGTAACGA
TCTTCTGCTTTGCCATCCGGCAGTTATTGGCGAACTTGCTTTGGGCAGCCTACGCGACAGGACCGCTGTGTTAACTTTTC
TCCGCGCACAGCGTGAGACTATCGTAGCAACCCACGACGAGGTTATGACTCTCATTGAGAGGCATAGCGTTTTTAGCATG
GGTATTGGCTACACGGATGCTCACTTGCTCGCTTCTGTCCTACTTGATCAGCGCACATCCCTTTGGACTCGAGACAAGCG
GCTCAAGCTAGCGGCCCTCAAAGCTGGCGCTGCTCTTTATGAGCCCTTTCACAATTAA
GTGATACTAGCAGATACTTCCATTTGGATTGATCATTTCCGCCGAGGTGATAACGATCTTGTAAAAATTATTGGTAACGA
TCTTCTGCTTTGCCATCCGGCAGTTATTGGCGAACTTGCTTTGGGCAGCCTACGCGACAGGACCGCTGTGTTAACTTTTC
TCCGCGCACAGCGTGAGACTATCGTAGCAACCCACGACGAGGTTATGACTCTCATTGAGAGGCATAGCGTTTTTAGCATG
GGTATTGGCTACACGGATGCTCACTTGCTCGCTTCTGTCCTACTTGATCAGCGCACATCCCTTTGGACTCGAGACAAGCG
GCTCAAGCTAGCGGCCCTCAAAGCTGGCGCTGCTCTTTATGAGCCCTTTCACAATTAA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13504.26 Da Isoelectric Point: 5.9526
>AT214906 WP_087602652.1 NZ_CP082773:2957332-2957700 [Escherichia coli O99:H6]
VSDTLPGTTHPDNNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLSSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLACEADTLSSCGYVYLAVYPTPEMKN
VSDTLPGTTHPDNNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLSSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLACEADTLSSCGYVYLAVYPTPEMKN
Download Length: 369 bp
>AT214906 NZ_CP110339:2193613-2193813 [Brucella sp. JSBI001]
ATGCGTTCAACCATTAATCTTGATGATAATCTCTTGGAAAAAGCCAGATCCCTGACGGGCACAAAGGAGACAGCCGCTTT
GGTCCGCCAAGCGTTAGAAGCACTCGTGCGCGTCGAGACTGGTAAACGGCTTATCGCTCTTGGAGGTACCATGCCGGACG
CTGAAGCCGCCCCCCGCCGTCGGAGCTCAGTGAATAAGTGA
ATGCGTTCAACCATTAATCTTGATGATAATCTCTTGGAAAAAGCCAGATCCCTGACGGGCACAAAGGAGACAGCCGCTTT
GGTCCGCCAAGCGTTAGAAGCACTCGTGCGCGTCGAGACTGGTAAACGGCTTATCGCTCTTGGAGGTACCATGCCGGACG
CTGAAGCCGCCCCCCGCCGTCGGAGCTCAGTGAATAAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|