Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
Location | 2002959..2003757 | Replicon | chromosome |
Accession | NZ_CP082773 | ||
Organism | Escherichia coli O99:H6 strain CU42ET-1 |
Toxin (Protein)
Gene name | yeeV | Uniprot ID | Q8VRA6 |
Locus tag | K8B87_RS09470 | Protein ID | WP_000854730.1 |
Coordinates | 2003380..2003757 (+) | Length | 126 a.a. |
Antitoxin (Protein)
Gene name | yeeU | Uniprot ID | A0A0P7R0L9 |
Locus tag | K8B87_RS09465 | Protein ID | WP_001285482.1 |
Coordinates | 2002959..2003333 (+) | Length | 125 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
K8B87_RS09440 (1999334) | 1999334..2000905 | - | 1572 | WP_021563310.1 | IS66 family transposase | - |
K8B87_RS09445 (2000925) | 2000925..2001272 | - | 348 | WP_000624618.1 | IS66 family insertion sequence element accessory protein TnpB | - |
K8B87_RS09450 (2001272) | 2001272..2001949 | - | 678 | WP_032154903.1 | IS66-like element accessory protein TnpA | - |
K8B87_RS09455 (2002025) | 2002025..2002246 | + | 222 | WP_000692315.1 | DUF987 domain-containing protein | - |
K8B87_RS09460 (2002265) | 2002265..2002909 | + | 645 | WP_087603051.1 | antitoxin of toxin-antitoxin stability system | - |
K8B87_RS09465 (2002959) | 2002959..2003333 | + | 375 | WP_001285482.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
K8B87_RS09470 (2003380) | 2003380..2003757 | + | 378 | WP_000854730.1 | TA system toxin CbtA family protein | Toxin |
K8B87_RS09475 (2003754) | 2003754..2004257 | + | 504 | WP_087602440.1 | DUF5983 family protein | - |
K8B87_RS09480 (2004254) | 2004254..2004451 | + | 198 | WP_042022639.1 | DUF957 domain-containing protein | - |
K8B87_RS09485 (2004548) | 2004548..2005391 | + | 844 | Protein_1835 | DUF4942 domain-containing protein | - |
K8B87_RS09495 (2005862) | 2005862..2006800 | + | 939 | WP_087602441.1 | glyoxylate/hydroxypyruvate reductase GhrA | - |
K8B87_RS09500 (2006855) | 2006855..2007592 | + | 738 | WP_000283664.1 | zinc-binding phosphatase | - |
K8B87_RS09505 (2007616) | 2007616..2008170 | + | 555 | WP_001764415.1 | molecular chaperone YcdY | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14212.21 Da Isoelectric Point: 7.2923
>T214896 WP_000854730.1 NZ_CP082773:2003380-2003757 [Escherichia coli O99:H6]
MKTLPDTHVREASRCPSPVTIWQTLLTQLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRSNYRMVNDIIRGEHSEAKR
MKTLPDTHVREASRCPSPVTIWQTLLTQLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRSNYRMVNDIIRGEHSEAKR
Download Length: 378 bp
>T214896 NZ_CP110313:c5121618-5121505 [Xanthomonas phaseoli pv. phaseoli]
TTGAAGGGCGAGCGGCGCGGCCAGTACCGCATCCGGATCAACGATCGATGGCGCATCTGCGTCCGATGGATGGAAGGCGA
TGTGGTCCAGGTCGAAATCATCGATTACCACTGA
TTGAAGGGCGAGCGGCGCGGCCAGTACCGCATCCGGATCAACGATCGATGGCGCATCTGCGTCCGATGGATGGAAGGCGA
TGTGGTCCAGGTCGAAATCATCGATTACCACTGA
Antitoxin
Download Length: 125 a.a. Molecular weight: 13791.44 Da Isoelectric Point: 4.7511
>AT214896 WP_001285482.1 NZ_CP082773:2002959-2003333 [Escherichia coli O99:H6]
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS
Download Length: 375 bp
>AT214896 NZ_CP110313:c5121487-5121197 [Xanthomonas phaseoli pv. phaseoli]
ATGACGGTCCTGCCCAATATCCACCCTGGCGCAATTCTGCTTGAGGAGTTTCTCCAGCCTCTGGGCATCAGCCAGAACGC
ACTGGCACGCGCCACCGGCGTCCCGCCGCGCCGTATCAAAAAAAGCGTGCTGGGCAAGCGCGGCATCACTGCCGACACTG
CCGTGCGTCTGGCCGCCGCGTTGGGAACCTTCGAGCGCTTCTGGCTTGGCCTGCAGGCCGACGACGAGCTGGAGCAGGCG
CATCGCGCGCTGGGCGACTTGCCGGCGCGGATCAAGCGGCTGGCGGCATGA
ATGACGGTCCTGCCCAATATCCACCCTGGCGCAATTCTGCTTGAGGAGTTTCTCCAGCCTCTGGGCATCAGCCAGAACGC
ACTGGCACGCGCCACCGGCGTCCCGCCGCGCCGTATCAAAAAAAGCGTGCTGGGCAAGCGCGGCATCACTGCCGACACTG
CCGTGCGTCTGGCCGCCGCGTTGGGAACCTTCGAGCGCTTCTGGCTTGGCCTGCAGGCCGACGACGAGCTGGAGCAGGCG
CATCGCGCGCTGGGCGACTTGCCGGCGCGGATCAAGCGGCTGGCGGCATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H2V671 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0P7R0L9 |