Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yeeU/CbtA-CbeA
Location 705512..706213 Replicon chromosome
Accession NZ_CP082773
Organism Escherichia coli O99:H6 strain CU42ET-1

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag K8B87_RS03325 Protein ID WP_087602994.1
Coordinates 705878..706213 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag K8B87_RS03320 Protein ID WP_032149459.1
Coordinates 705512..705847 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8B87_RS03295 (701459) 701459..701677 - 219 WP_001683511.1 AlpA family phage regulatory protein -
K8B87_RS03300 (701795) 701795..702409 - 615 WP_001683512.1 inovirus Gp2 family protein -
K8B87_RS03305 (703002) 703002..703955 + 954 WP_087602991.1 hypothetical protein -
K8B87_RS03310 (704191) 704191..705009 + 819 WP_087602992.1 DUF932 domain-containing protein -
K8B87_RS03315 (705039) 705039..705512 + 474 WP_087602993.1 DNA repair protein RadC -
K8B87_RS03320 (705512) 705512..705847 + 336 WP_032149459.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
K8B87_RS03325 (705878) 705878..706213 + 336 WP_087602994.1 TA system toxin CbtA family protein Toxin
K8B87_RS03330 (706344) 706344..707177 + 834 WP_087602995.1 DUF4942 domain-containing protein -
K8B87_RS03335 (707254) 707254..707502 + 249 WP_024187601.1 ribbon-helix-helix domain-containing protein -
K8B87_RS03340 (707506) 707506..707781 + 276 WP_001683517.1 type II toxin-antitoxin system RelE/ParE family toxin -
K8B87_RS03345 (707895) 707895..708692 + 798 WP_001552326.1 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimB / fimE / fimA / fimI / fimC 688551..721684 33133


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(10-110)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12810.86 Da        Isoelectric Point: 8.9372

>T214888 WP_087602994.1 NZ_CP082773:705878-706213 [Escherichia coli O99:H6]
MKIIPATTLRATTSYLSPVVVWQILLARLLEQHYGLNLNDTPFNNEKVIQEHIDAGIPLVDAVNFLVEKYELIRIDRKGF
SWQEQTPYLRAVDILRARQATGLLRRCHNTP

Download         Length: 336 bp

>T214888 NZ_CP110308:50007-50423 [Xanthomonas phaseoli pv. phaseoli]
ATGATCGTTCTCGATACCAACGTCGTTTCCGAGGCGATGAAGCCCGAGCCGCACCCATCCGTGCGGACCTGGTTGAACGA
TCAAGCCGCTGAAACACTGTACCTGTCCAGCGTGACGCTGGCCGAACTGCTATTTGGCATCGCTGCGCTTCCTGCCGGTA
AGCGCAAGGACATGCTGGAACAGGCCCTTGATGGCCTCATGGGCCTGTTTAGGGATCGGGTGTTGCCATTCGACATCGAT
GCAGCGCGGCGTTATGCCGAATTGGCCGTGACGGCAAAGATCGGAGGGCGAGGATTTCCGACACCCGACGGCTACATCGC
AGCGATTGCTGCCTCGCGGGGTTTCATTGTGGCGTCACGCGACACGGCCCCTTACGAAGCGGCCGGCGTAACCGTCATCA
ATCCGTGGGAAGGGTGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12554.52 Da        Isoelectric Point: 7.7723

>AT214888 WP_032149459.1 NZ_CP082773:705512-705847 [Escherichia coli O99:H6]
MLQKDKVMQQEWGLPCTVTPRFTARLVQERHNLHYLADRAAITGKFSSPDLLHIDQAFPVLMKQLELKLADGELTPCQQR
TVTLYAKGLTCEADTLGSSGYVYIAIYPTQR

Download         Length: 336 bp

>AT214888 NZ_CP110308:49756-50010 [Xanthomonas phaseoli pv. phaseoli]
ATGGCAATGCTGACAGTACGTAATCTGCCGGATGATGTGCACCGCGCATTGCGCATGCGGGCCGCTCAAAATGGGCACAG
CACCGAGGCCGAGGTCCGCGAGATTCTGGCGACCGCAGTCAAGCCAGAGACGCGCGTTCGCCTAGGCGAAGCCTTGGCGG
CTTTGGGTCGCAAGATTGGCCTGACGAATGAGGACTTCGAGGTCTTCGATCGGGTAAGAGACAAGACGCCGGCCGTCCCG
CCGAGGCTTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References