Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | sanaTA/AbiEii-DUF6088 |
| Location | 4254243..4255524 | Replicon | chromosome |
| Accession | NZ_CP082772 | ||
| Organism | Escherichia coli O2:H1 strain HM670 | ||
Toxin (Protein)
| Gene name | sanaT | Uniprot ID | - |
| Locus tag | K8B93_RS20525 | Protein ID | WP_021528665.1 |
| Coordinates | 4254631..4255524 (+) | Length | 298 a.a. |
Antitoxin (Protein)
| Gene name | sanaA | Uniprot ID | S1P7P2 |
| Locus tag | K8B93_RS20520 | Protein ID | WP_000208382.1 |
| Coordinates | 4254243..4254638 (+) | Length | 132 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K8B93_RS20475 (4249748) | 4249748..4250221 | + | 474 | WP_001538139.1 | antirestriction protein | - |
| K8B93_RS20480 (4250237) | 4250237..4250714 | + | 478 | Protein_3986 | RadC family protein | - |
| K8B93_RS20485 (4250777) | 4250777..4250998 | + | 222 | WP_000692326.1 | DUF987 domain-containing protein | - |
| K8B93_RS20490 (4251017) | 4251017..4251661 | + | 645 | Protein_3988 | antitoxin of toxin-antitoxin stability system | - |
| K8B93_RS20495 (4251711) | 4251711..4252091 | + | 381 | WP_001285599.1 | type IV toxin-antitoxin system YeeU family antitoxin | - |
| K8B93_RS20500 (4252168) | 4252168..4252545 | + | 378 | WP_000854689.1 | TA system toxin CbtA family protein | - |
| K8B93_RS20505 (4252542) | 4252542..4253030 | + | 489 | WP_000761698.1 | DUF5983 family protein | - |
| K8B93_RS20510 (4253047) | 4253047..4253244 | + | 198 | WP_000839250.1 | DUF957 domain-containing protein | - |
| K8B93_RS20515 (4253329) | 4253329..4254174 | + | 846 | WP_001530851.1 | DUF4942 domain-containing protein | - |
| K8B93_RS20520 (4254243) | 4254243..4254638 | + | 396 | WP_000208382.1 | DUF6088 family protein | Antitoxin |
| K8B93_RS20525 (4254631) | 4254631..4255524 | + | 894 | WP_021528665.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| K8B93_RS20530 (4255995) | 4255995..4256165 | + | 171 | Protein_3996 | IS110 family transposase | - |
| K8B93_RS20535 (4256514) | 4256514..4258013 | + | 1500 | WP_000174401.1 | IS21-like element ISEc10 family transposase | - |
| K8B93_RS20540 (4258010) | 4258010..4258765 | + | 756 | Protein_3998 | IS21-like element ISEc10 family helper ATPase IstB | - |
| K8B93_RS20545 (4259392) | 4259392..4260375 | + | 984 | WP_021528669.1 | KpsF/GutQ family sugar-phosphate isomerase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 298 a.a. Molecular weight: 34268.37 Da Isoelectric Point: 5.9850
>T214883 WP_021528665.1 NZ_CP082772:4254631-4255524 [Escherichia coli O2:H1]
MPELTSLFPDVADALDIESVAIVEKDYFVVDLLRLLKEIKPETHTLVFAGGTALSKAGISLNRMSEDIDIKLVPTENFMQ
NGRDKRRKIRKEIVQIITDVIHNSDIFSLDNENARITRDEYRYNEISVRYPQTFAQVPCLRPFIKLELMESTLLEHPESR
DIYSLVTELTGKGTPITAFPCATILSTQAEKLISMMRRTAAHLRNPEQQDDEFLVRHIYDNYCIVREKGVNVPVLKNFVQ
ICIQQDIERYGNQYPQFCSSPVDELKKGLDALRDYPVHKLRFQRFVNPMVFGNTQIN
MPELTSLFPDVADALDIESVAIVEKDYFVVDLLRLLKEIKPETHTLVFAGGTALSKAGISLNRMSEDIDIKLVPTENFMQ
NGRDKRRKIRKEIVQIITDVIHNSDIFSLDNENARITRDEYRYNEISVRYPQTFAQVPCLRPFIKLELMESTLLEHPESR
DIYSLVTELTGKGTPITAFPCATILSTQAEKLISMMRRTAAHLRNPEQQDDEFLVRHIYDNYCIVREKGVNVPVLKNFVQ
ICIQQDIERYGNQYPQFCSSPVDELKKGLDALRDYPVHKLRFQRFVNPMVFGNTQIN
Download Length: 894 bp
>T214883 NZ_CP110305:c8605-8189 [Xanthomonas phaseoli pv. phaseoli]
ATGATCGTTCTCGATACCAACGTCGTTTCCGAGGCGATGAAGCCCGAGCCGCACCCATCCGTGCGGACCTGGTTGAACGA
TCAAGCCGCTGAAACACTGTACCTGTCCAGCGTGACGCTGGCCGAACTGCTATTTGGCATCGCTGCGCTTCCTGCCGGTA
AGCGCAAGGACATGCTGGAACAGGCCCTTGATGGCCTCATGGGCCTGTTTAGGGATCGGGTGTTGCCATTCGACATCGAT
GCAGCGCGGCGTTATGCCGAATTGGCCGTGACGGCAAAGATCGGAGGGCGAGGATTTCCGACACCCGACGGCTACATCGC
AGCGATTGCTGCCTCGCGGGGTTTCATTGTGGCGTCACGCGACACGGCCCCTTACGAAGCGGCCGGCGTAACCGTCATCA
ATCCGTGGGAAGGGTGA
ATGATCGTTCTCGATACCAACGTCGTTTCCGAGGCGATGAAGCCCGAGCCGCACCCATCCGTGCGGACCTGGTTGAACGA
TCAAGCCGCTGAAACACTGTACCTGTCCAGCGTGACGCTGGCCGAACTGCTATTTGGCATCGCTGCGCTTCCTGCCGGTA
AGCGCAAGGACATGCTGGAACAGGCCCTTGATGGCCTCATGGGCCTGTTTAGGGATCGGGTGTTGCCATTCGACATCGAT
GCAGCGCGGCGTTATGCCGAATTGGCCGTGACGGCAAAGATCGGAGGGCGAGGATTTCCGACACCCGACGGCTACATCGC
AGCGATTGCTGCCTCGCGGGGTTTCATTGTGGCGTCACGCGACACGGCCCCTTACGAAGCGGCCGGCGTAACCGTCATCA
ATCCGTGGGAAGGGTGA
Antitoxin
Download Length: 132 a.a. Molecular weight: 14640.09 Da Isoelectric Point: 11.3150
>AT214883 WP_000208382.1 NZ_CP082772:4254243-4254638 [Escherichia coli O2:H1]
MTTKDRIQSRLNRSKRYVFTRDDFRDIAGYDQVGRALRTLVNEGKLMKVGYGVYTKARRNIITGKIMPAAPGGSAAVITE
ALERLNIRYRLAGATECYNKGQSTQIPVSLGIKTPSRFKRMLIVGKSKINA
MTTKDRIQSRLNRSKRYVFTRDDFRDIAGYDQVGRALRTLVNEGKLMKVGYGVYTKARRNIITGKIMPAAPGGSAAVITE
ALERLNIRYRLAGATECYNKGQSTQIPVSLGIKTPSRFKRMLIVGKSKINA
Download Length: 396 bp
>AT214883 NZ_CP110305:c8856-8602 [Xanthomonas phaseoli pv. phaseoli]
ATGGCAATGCTGACAGTACGTAATCTGCCGGATGATGTGCACCGCGCATTGCGCATGCGGGCCGCTCAAAATGGGCACAG
CACCGAGGCCGAGGTCCGCGAGATTCTGGCGACCGCAGTCAAGCCAGAGACGCGCGTTCGCCTAGGCGAAGCCTTGGCGG
CTTTGGGTCGCAAGATTGGCCTGACGAATGAGGACTTCGAGGTCTTCGATCGGGTAAGAGACAAGACGCCGGCCGTCCCG
CCGAGGCTTGAATGA
ATGGCAATGCTGACAGTACGTAATCTGCCGGATGATGTGCACCGCGCATTGCGCATGCGGGCCGCTCAAAATGGGCACAG
CACCGAGGCCGAGGTCCGCGAGATTCTGGCGACCGCAGTCAAGCCAGAGACGCGCGTTCGCCTAGGCGAAGCCTTGGCGG
CTTTGGGTCGCAAGATTGGCCTGACGAATGAGGACTTCGAGGTCTTCGATCGGGTAAGAGACAAGACGCCGGCCGTCCCG
CCGAGGCTTGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|