214882

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4251711..4252545 Replicon chromosome
Accession NZ_CP082772
Organism Escherichia coli O2:H1 strain HM670

Toxin (Protein)


Gene name yeeV Uniprot ID A0A8E0IX31
Locus tag K8B93_RS20500 Protein ID WP_000854689.1
Coordinates 4252168..4252545 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A8E0IVP8
Locus tag K8B93_RS20495 Protein ID WP_001285599.1
Coordinates 4251711..4252091 (+) Length 127 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8B93_RS20460 (4247797) 4247797..4248252 + 456 WP_000581502.1 IrmA family protein -
K8B93_RS20465 (4248395) 4248395..4248484 + 90 WP_225385657.1 DUF905 family protein -
K8B93_RS20470 (4248663) 4248663..4249484 + 822 WP_001234555.1 DUF932 domain-containing protein -
K8B93_RS20475 (4249748) 4249748..4250221 + 474 WP_001538139.1 antirestriction protein -
K8B93_RS20480 (4250237) 4250237..4250714 + 478 Protein_3986 RadC family protein -
K8B93_RS20485 (4250777) 4250777..4250998 + 222 WP_000692326.1 DUF987 domain-containing protein -
K8B93_RS20490 (4251017) 4251017..4251661 + 645 Protein_3988 antitoxin of toxin-antitoxin stability system -
K8B93_RS20495 (4251711) 4251711..4252091 + 381 WP_001285599.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
K8B93_RS20500 (4252168) 4252168..4252545 + 378 WP_000854689.1 TA system toxin CbtA family protein Toxin
K8B93_RS20505 (4252542) 4252542..4253030 + 489 WP_000761698.1 DUF5983 family protein -
K8B93_RS20510 (4253047) 4253047..4253244 + 198 WP_000839250.1 DUF957 domain-containing protein -
K8B93_RS20515 (4253329) 4253329..4254174 + 846 WP_001530851.1 DUF4942 domain-containing protein -
K8B93_RS20520 (4254243) 4254243..4254638 + 396 WP_000208382.1 DUF6088 family protein -
K8B93_RS20525 (4254631) 4254631..4255524 + 894 WP_021528665.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
K8B93_RS20530 (4255995) 4255995..4256165 + 171 Protein_3996 IS110 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14042.07 Da        Isoelectric Point: 9.1510

>T214882 WP_000854689.1 NZ_CP082772:4252168-4252545 [Escherichia coli O2:H1]
MKTLPDTHVRAASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR

Download         Length: 378 bp

>T214882 NZ_CP110304:c3240-2824 [Xanthomonas phaseoli pv. phaseoli]
ATGATCGTTCTCGATACCAACGTCGTTTCCGAGGCGATGAAGCCCGAGCCGCACCCATCCGTGCGGACCTGGTTGAACGA
TCAAGCCGCTGAAACACTGTACCTGTCCAGCGTGACGCTGGCCGAACTGCTATTTGGCATCGCTGCGCTTCCTGCCGGTA
AGCGCAAGGACATGCTGGAACAGGCCCTTGATGGCCTCATGGGCCTGTTTAGGGATCGGGTGTTGCCATTCGACATCGAT
GCAGCGCGGCGTTATGCCGAATTGGCCGTGACGGCAAAGATCGGAGGGCGAGGATTTCCGACACCCGACGGCTACATCGC
AGCGATTGCTGCCTCGCGGGGTTTCATTGTGGCGTCACGCGACACGGCCCCTTACGAAGCGGCCGGCGTAACCGTCATCA
ATCCGTGGGAAGGGTGA

Antitoxin


Download         Length: 127 a.a.        Molecular weight: 13984.78 Da        Isoelectric Point: 5.0823

>AT214882 WP_001285599.1 NZ_CP082772:4251711-4252091 [Escherichia coli O2:H1]
MSDTLPGTTLPDDNKDRPWWGLPCTVTPCFGARLLQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE

Download         Length: 381 bp

>AT214882 NZ_CP110304:c3491-3237 [Xanthomonas phaseoli pv. phaseoli]
ATGGCAATGCTGACAGTACGTAATCTGCCGGATGATGTGCACCGCGCATTGCGCATGCGGGCCGCTCAAAATGGGCACAG
CACCGAGGCCGAGGTCCGCGAGATTCTGGCGACCGCAGTCAAGCCAGAGACGCGCGTTCGCCTAGGCGAAGCCTTGGCGG
CTTTGGGTCGCAAGATTGGCCTGACGAATGAGGACTTCGAGGTCTTCGATCGGGTAAGAGACAAGACGCCGGCCGTCCCG
CCGAGGCTTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References