214881

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4110329..4110983 Replicon chromosome
Accession NZ_CP082772
Organism Escherichia coli O2:H1 strain HM670

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag K8B93_RS19760 Protein ID WP_000244781.1
Coordinates 4110329..4110736 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag K8B93_RS19765 Protein ID WP_000354046.1
Coordinates 4110717..4110983 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8B93_RS19740 (4106286) 4106286..4108019 - 1734 WP_000813189.1 single-stranded-DNA-specific exonuclease RecJ -
K8B93_RS19745 (4108025) 4108025..4108735 - 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
K8B93_RS19750 (4108760) 4108760..4109656 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
K8B93_RS19755 (4109768) 4109768..4110289 + 522 WP_001055874.1 flavodoxin FldB -
K8B93_RS19760 (4110329) 4110329..4110736 - 408 WP_000244781.1 protein YgfX Toxin
K8B93_RS19765 (4110717) 4110717..4110983 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
K8B93_RS19770 (4111226) 4111226..4112206 + 981 WP_000886079.1 tRNA-modifying protein YgfZ -
K8B93_RS19775 (4112283) 4112283..4112942 - 660 WP_000250274.1 hemolysin III family protein -
K8B93_RS19780 (4113106) 4113106..4113417 - 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
K8B93_RS19785 (4113462) 4113462..4114895 + 1434 WP_001350137.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T214881 WP_000244781.1 NZ_CP082772:c4110736-4110329 [Escherichia coli O2:H1]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T214881 NZ_CP110303:c5036078-5035965 [Xanthomonas phaseoli pv. phaseoli]
TTGAAGGGCGAGCGGCGCGGCCAGTACCGCATCCGGATCAACGATCGATGGCGCATCTGCGTCCGATGGATGGAAGGCGA
TGTGGTCCAGGTCGAAATCATCGATTACCACTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT214881 WP_000354046.1 NZ_CP082772:c4110983-4110717 [Escherichia coli O2:H1]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT214881 NZ_CP110303:c5035947-5035657 [Xanthomonas phaseoli pv. phaseoli]
ATGACGGTCCTGCCCAATATCCACCCTGGCGCAATTCTGCTTGAGGAGTTTCTCCAGCCTCTGGGCATCAGCCAGAACGC
ACTGGCACGCGCCACCGGCGTCCCGCCGCGCCGTATCAAAAAAAGCGTGCTGGGCAAGCGCGGCATCACTGCCGACACTG
CCGTGCGTCTGGCCGCCGCGTTGGGAACCTTCGAGCGCTTCTGGCTTGGCCTGCAGGCCGACGACGAGCTGGAGCAGGCG
CATCGCGCGCTGGGCGACTTGCCGGCGCGGATCAAGCGGCTGGCGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QD57

References