Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3190494..3191325 Replicon chromosome
Accession NZ_CP082772
Organism Escherichia coli O2:H1 strain HM670

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag K8B93_RS15630 Protein ID WP_000854814.1
Coordinates 3190951..3191325 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1PWQ3
Locus tag K8B93_RS15625 Protein ID WP_001285586.1
Coordinates 3190494..3190862 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8B93_RS15590 (3185711) 3185711..3186781 + 1071 WP_000102631.1 patatin-like phospholipase family protein -
K8B93_RS15595 (3186917) 3186917..3187594 + 678 WP_001362823.1 hypothetical protein -
K8B93_RS15600 (3187610) 3187610..3188020 + 411 WP_000846704.1 hypothetical protein -
K8B93_RS15605 (3188241) 3188241..3189062 + 822 WP_001234569.1 DUF932 domain-containing protein -
K8B93_RS15610 (3189153) 3189153..3189638 + 486 WP_000213703.1 antirestriction protein -
K8B93_RS15615 (3189654) 3189654..3190130 + 477 WP_001351157.1 RadC family protein -
K8B93_RS15620 (3190199) 3190199..3190420 + 222 WP_000692323.1 DUF987 domain-containing protein -
K8B93_RS15625 (3190494) 3190494..3190862 + 369 WP_001285586.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
K8B93_RS15630 (3190951) 3190951..3191325 + 375 WP_000854814.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
K8B93_RS15635 (3191322) 3191322..3191516 + 195 WP_000988601.1 DUF5983 family protein -
K8B93_RS15640 (3191562) 3191562..3191642 + 81 Protein_3040 hypothetical protein -
K8B93_RS15645 (3191931) 3191931..3192011 - 81 WP_023441679.1 hypothetical protein -
K8B93_RS15650 (3191990) 3191990..3192313 + 324 WP_223216378.1 EutP/PduV family microcompartment system protein -
K8B93_RS15655 (3192414) 3192414..3192743 - 330 WP_000450409.1 DUF496 family protein -
K8B93_RS15660 (3192915) 3192915..3193973 - 1059 WP_001200890.1 FUSC family protein -
K8B93_RS15665 (3194171) 3194171..3194644 - 474 WP_001105376.1 DNA gyrase inhibitor SbmC -
K8B93_RS15670 (3194763) 3194763..3195929 - 1167 WP_001297905.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T214878 WP_000854814.1 NZ_CP082772:3190951-3191325 [Escherichia coli O2:H1]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T214878 NZ_CP110302:c31817-31401 [Xanthomonas citri pv. fuscans]
ATGATCGTTCTCGATACCAACGTCGTTTCCGAGGCGATGAAGCCCGAGCCGCACCCATCCGTGCGGACCTGGTTGAACGA
TCAAGCCGCTGAAACACTGTACCTGTCCAGCGTGACGCTGGCCGAACTGCTATTTGGCATCGCTGCGCTTCCTGCCGGTA
AGCGCAAGGACATGCTGGAACAGGCCCTTGATGGCCTCATGGGCCTGTTTAGGGATCGGGTGTTGCCATTCGACATCGAT
GCAGCGCGGCGTTATGCCGAATTGGCCGTGACGGCAAAGATCGGAGGGCGAGGATTTCCGACACCCGACGGCTACATCGC
AGCGATTGCTGCCTCGCGGGGTTTCATTGTGGCGTCACGCGACACGGCCCCTTACGAAGCGGCCGGCGTAACCGTCATCA
ATCCGTGGGAAGGGTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13563.41 Da        Isoelectric Point: 5.0468

>AT214878 WP_001285586.1 NZ_CP082772:3190494-3190862 [Escherichia coli O2:H1]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELSPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT214878 NZ_CP110302:c32068-31814 [Xanthomonas citri pv. fuscans]
ATGGCAATGCTGACAGTACGTAATCTGCCGGATGATGTGCACCGCGCATTGCGCATGCGGGCCGCTCAAAATGGGCACAG
CACCGAGGCCGAGGTCCGCGAGATTCTGGCGACCGCAGTCAAGCCAGAGACGCGCGTTCGCCTAGGCGAAGCCTTGGCGG
CTTTGGGTCGCAAGATTGGCCTGACGAATGAGGACTTCGAGGTCTTCGATCGGGTAAGAGACAAGACGCCGGCCGTCCCG
CCGAGGCTTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB S1PWQ3

References