214877

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 3036229..3036707 Replicon chromosome
Accession NZ_CP082772
Organism Escherichia coli O2:H1 strain HM670

Toxin (Protein)


Gene name parE_1 Uniprot ID D8A5B3
Locus tag K8B93_RS15075 Protein ID WP_000936799.1
Coordinates 3036420..3036707 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID D8A5B4
Locus tag K8B93_RS15070 Protein ID WP_000100899.1
Coordinates 3036229..3036420 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8B93_RS15030 (3031722) 3031722..3032000 - 279 WP_024193993.1 hypothetical protein -
K8B93_RS15035 (3032168) 3032168..3032323 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
K8B93_RS15040 (3032561) 3032561..3033226 - 666 WP_000150294.1 epoxyqueuosine reductase QueH -
K8B93_RS15045 (3033401) 3033401..3033826 - 426 WP_001151152.1 DUF977 family protein -
K8B93_RS15050 (3033867) 3033867..3034937 - 1071 WP_001262355.1 hypothetical protein -
K8B93_RS15055 (3035009) 3035009..3035434 - 426 WP_000693918.1 toxin YdaT family protein -
K8B93_RS15060 (3035418) 3035418..3035690 - 273 WP_000887447.1 YdaS family helix-turn-helix protein -
K8B93_RS15065 (3035800) 3035800..3036201 + 402 WP_001329851.1 helix-turn-helix domain-containing protein -
K8B93_RS15070 (3036229) 3036229..3036420 + 192 WP_000100899.1 hypothetical protein Antitoxin
K8B93_RS15075 (3036420) 3036420..3036707 + 288 WP_000936799.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K8B93_RS15080 (3036979) 3036979..3037131 + 153 WP_000379609.1 DUF1391 family protein -
K8B93_RS15085 (3037143) 3037143..3037517 + 375 WP_001553098.1 hypothetical protein -
K8B93_RS15090 (3037507) 3037507..3037728 - 222 WP_000202161.1 hypothetical protein -
K8B93_RS15095 (3038296) 3038296..3039144 + 849 WP_000935606.1 Rha family phage regulatory protein -
K8B93_RS15100 (3039190) 3039190..3039411 + 222 WP_000560231.1 cell division protein FtsZ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - ybtS / ybtX / ybtQ / ybtP 2999928..3052345 52417


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10929.85 Da        Isoelectric Point: 10.1360

>T214877 WP_000936799.1 NZ_CP082772:3036420-3036707 [Escherichia coli O2:H1]
MLPILWLPSARDDLRQIVAYIAKENIPAARRLKIRIETSVLALSEHPYLYPPSDRVSGLREIVVHPNYIVLYRVATSSIE
IANIVHARRQFPFPI

Download         Length: 288 bp

>T214877 NZ_CP110301:c4608713-4608561 [Xanthomonas citri pv. fuscans]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTTTCGGCCGGCGTGATGACGGGCTGCAACACCGTGGCCGGCGC
CGGCAAGGACATGCAGGGTGCGGGTAACAAGGTCGAGAAAACGGCCGAAAAATGCAGCGACGGTAAGTGCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7035.80 Da        Isoelectric Point: 4.0270

>AT214877 WP_000100899.1 NZ_CP082772:3036229-3036420 [Escherichia coli O2:H1]
MSTALSPIVSEFETTEQENSYNEWLRAKVASSLADPRPSIPHDEVMAEMENLIAQIAVTNRSE

Download         Length: 192 bp

>AT214877 NZ_CP110301:c4608486-4608352 [Xanthomonas citri pv. fuscans]
ATGAAGCGTGCAATTGTGCTGCTGGTGCTGTCGATGTTGTCGGTGGGAATGCTGGCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCAGCGCGTAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D8A5B3

Antitoxin

Source ID Structure
AlphaFold DB A0A161RC07

References