Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 1145648..1146446 | Replicon | chromosome |
| Accession | NZ_CP082772 | ||
| Organism | Escherichia coli O2:H1 strain HM670 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | Q8VRA6 |
| Locus tag | K8B93_RS05360 | Protein ID | WP_000854730.1 |
| Coordinates | 1145648..1146025 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A0P0SQV8 |
| Locus tag | K8B93_RS05365 | Protein ID | WP_001285481.1 |
| Coordinates | 1146072..1146446 (-) | Length | 125 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K8B93_RS05335 (1140904) | 1140904..1142308 | + | 1405 | Protein_1025 | IS66 family transposase | - |
| K8B93_RS05340 (1142562) | 1142562..1143695 | - | 1134 | WP_000555401.1 | IS110-like element ISEc45 family transposase | - |
| K8B93_RS05345 (1143756) | 1143756..1143944 | + | 189 | Protein_1027 | IS66 family transposase | - |
| K8B93_RS05350 (1144092) | 1144092..1145080 | + | 989 | Protein_1028 | IS630 family transposase | - |
| K8B93_RS05355 (1145159) | 1145159..1145651 | - | 493 | Protein_1029 | DUF5983 family protein | - |
| K8B93_RS05360 (1145648) | 1145648..1146025 | - | 378 | WP_000854730.1 | TA system toxin CbtA family protein | Toxin |
| K8B93_RS05365 (1146072) | 1146072..1146446 | - | 375 | WP_001285481.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| K8B93_RS05370 (1146496) | 1146496..1147140 | - | 645 | Protein_1032 | antitoxin of toxin-antitoxin stability system | - |
| K8B93_RS05375 (1147159) | 1147159..1147380 | - | 222 | WP_000692326.1 | DUF987 domain-containing protein | - |
| K8B93_RS05380 (1147443) | 1147443..1147919 | - | 477 | WP_021528430.1 | RadC family protein | - |
| K8B93_RS05385 (1147935) | 1147935..1148408 | - | 474 | WP_001313575.1 | antirestriction protein | - |
| K8B93_RS05390 (1148502) | 1148502..1148747 | - | 246 | WP_001164966.1 | hypothetical protein | - |
| K8B93_RS05395 (1148747) | 1148747..1149568 | - | 822 | WP_001234359.1 | DUF932 domain-containing protein | - |
| K8B93_RS05400 (1149668) | 1149668..1149901 | - | 234 | WP_001213776.1 | DUF905 family protein | - |
| K8B93_RS05405 (1150019) | 1150019..1150471 | - | 453 | WP_000682723.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 1136748..1193593 | 56845 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14212.21 Da Isoelectric Point: 7.2923
>T214862 WP_000854730.1 NZ_CP082772:c1146025-1145648 [Escherichia coli O2:H1]
MKTLPDTHVREASRCPSPVTIWQTLLTQLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRSNYRMVNDIIRGEHSEAKR
MKTLPDTHVREASRCPSPVTIWQTLLTQLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRSNYRMVNDIIRGEHSEAKR
Download Length: 378 bp
>T214862 NZ_CP110294:216227-216493 [Enterococcus faecium]
ATGAGTAACTATACAGTCGCAATCAAAAACTCTGCGAAAGTGGATTTAAGAAAAATCAAGCAATCGAATTTAAAGAAACA
ATTTGAAGAAGTGATTCAGACATTGAAGGAAGATCCATATATGCCCACGCAGTCTTTTGAAAAGCTGAGACCTACACATG
AAGGCAGATACTCACGCAGGCTGAATAGACAGCATCGAGTGGTTTACAAAGTTGATGAGGAAAATAAAGTTGTGGAAATT
TATTCTGCCTGGACACATTATGAGTGA
ATGAGTAACTATACAGTCGCAATCAAAAACTCTGCGAAAGTGGATTTAAGAAAAATCAAGCAATCGAATTTAAAGAAACA
ATTTGAAGAAGTGATTCAGACATTGAAGGAAGATCCATATATGCCCACGCAGTCTTTTGAAAAGCTGAGACCTACACATG
AAGGCAGATACTCACGCAGGCTGAATAGACAGCATCGAGTGGTTTACAAAGTTGATGAGGAAAATAAAGTTGTGGAAATT
TATTCTGCCTGGACACATTATGAGTGA
Antitoxin
Download Length: 125 a.a. Molecular weight: 13817.53 Da Isoelectric Point: 4.7511
>AT214862 WP_001285481.1 NZ_CP082772:c1146446-1146072 [Escherichia coli O2:H1]
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTIG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTIG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS
Download Length: 375 bp
>AT214862 NZ_CP110294:215964-216227 [Enterococcus faecium]
ATGGCTAATACAACGATGAATCCTAGCACTGCTCGTAAAAATTTTTATCAGTTATTGAAAGAGGTAAATGAAAATCATAC
TGAAATCGAGATTATTAGTGATCGTAGTGGAAACAATGCTGTATTGATTGGGCTAGAAGACTGGAGAGCGATTCAAGAAA
CCCTTTTTCTTGAGCAAACAGGTACTTTAGATAAAGTACGAGACCGCGAAAAAGACGACAGTGGCTTTACGAATATCGAT
GATATTGATTGGGAAGCTCTTTGA
ATGGCTAATACAACGATGAATCCTAGCACTGCTCGTAAAAATTTTTATCAGTTATTGAAAGAGGTAAATGAAAATCATAC
TGAAATCGAGATTATTAGTGATCGTAGTGGAAACAATGCTGTATTGATTGGGCTAGAAGACTGGAGAGCGATTCAAGAAA
CCCTTTTTCTTGAGCAAACAGGTACTTTAGATAAAGTACGAGACCGCGAAAAAGACGACAGTGGCTTTACGAATATCGAT
GATATTGATTGGGAAGCTCTTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H2V671 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0P0SQV8 |