Detailed information of TA system TA021486

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1890657..1891433
• Replicon: chromosome
• Accession: NC_007795
• Organism: Staphylococcus aureus subsp. aureus NCTC 8325

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: Q2FX91
• Locus tag: SAOUHSC_01986
• Protein ID: YP_500483.1
• Coordinates: 1890657..1890809 (-)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: Q2FX90
• Locus tag: SAOUHSC_01987
• Protein ID: YP_500484.1
• Coordinates: 1890834..1891433 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAOUHSC_01982	1886620..1887441	+	822	YP_500479.1	ribosomal large subunit pseudouridine synthase D	-
SAOUHSC_01983	1887904..1889289	-	1386	YP_500480.1	fumarate hydratase	-
SAOUHSC_01984	1889485..1889880	-	396	YP_500481.1	hypothetical protein	-
SAOUHSC_01985	1889999..1890361	+	363	YP_500482.1	hypothetical protein	-
SAOUHSC_01986	1890657..1890809	-	153	YP_500483.1	hypothetical protein	Toxin
SAOUHSC_01987	1890834..1891433	-	600	YP_500484.1	hypothetical protein	Antitoxin
SAOUHSC_01988	1891592..1892062	-	471	YP_500485.1	hypothetical protein	-
SAOUHSC_01989	1892067..1893209	-	1143	YP_500486.1	hypothetical protein	-
SAOUHSC_01990	1893345..1894073	-	729	YP_500487.1	amino acid ABC transporter ATP-binding protein	-
SAOUHSC_01991	1894060..1895517	-	1458	YP_500488.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5936.28 Da
• Isoelectric Point: 3.8962

>T21486 YP_500483.1 NC_007795:c1890809-1890657 [Staphylococcus aureus subsp. aureus NCTC 8325]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Nucleotide

• Length: 153 bp

>T21486 NC_007795:c1890809-1890657 [Staphylococcus aureus subsp. aureus NCTC 8325]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATCTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22343.47 Da
• Isoelectric Point: 5.1445

>AT21486 YP_500484.1 NC_007795:c1891433-1890834 [Staphylococcus aureus subsp. aureus NCTC 8325]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT21486 NC_007795:c1891433-1890834 [Staphylococcus aureus subsp. aureus NCTC 8325]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Structures

Toxin

• AlphaFold DB: Q2FX91

Antitoxin

• AlphaFold DB: Q2FX90