Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /RES-TIGR02293 |
| Location | 85293..86203 | Replicon | plasmid pKP12-vir |
| Accession | NZ_CP082766 | ||
| Organism | Klebsiella pneumoniae strain 12 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A663AYG0 |
| Locus tag | FTO26_RS27475 | Protein ID | WP_004026354.1 |
| Coordinates | 85293..85763 (-) | Length | 157 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A6P1V3Q9 |
| Locus tag | FTO26_RS27480 | Protein ID | WP_004026357.1 |
| Coordinates | 85760..86203 (-) | Length | 148 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FTO26_RS27435 (FTO26_027435) | 80609..80923 | + | 315 | WP_011251273.1 | hypothetical protein | - |
| FTO26_RS27440 (FTO26_027440) | 80932..81426 | + | 495 | WP_011251274.1 | hypothetical protein | - |
| FTO26_RS27445 (FTO26_027445) | 81432..81872 | + | 441 | WP_011251275.1 | hypothetical protein | - |
| FTO26_RS27450 (FTO26_027450) | 82297..83253 | - | 957 | WP_011251280.1 | DsbA family protein | - |
| FTO26_RS27455 (FTO26_027455) | 83313..83654 | - | 342 | WP_011251281.1 | hypothetical protein | - |
| FTO26_RS27460 (FTO26_027460) | 83668..83979 | - | 312 | WP_011251282.1 | hypothetical protein | - |
| FTO26_RS27465 (FTO26_027465) | 83996..84445 | - | 450 | WP_011251283.1 | thioredoxin fold domain-containing protein | - |
| FTO26_RS27475 (FTO26_027475) | 85293..85763 | - | 471 | WP_004026354.1 | RES family NAD+ phosphorylase | Toxin |
| FTO26_RS27480 (FTO26_027480) | 85760..86203 | - | 444 | WP_004026357.1 | DUF2384 domain-containing protein | Antitoxin |
| FTO26_RS27485 (FTO26_027485) | 86304..86807 | - | 504 | Protein_99 | DUF4113 domain-containing protein | - |
| FTO26_RS27490 (FTO26_027490) | 87013..87993 | - | 981 | WP_000019473.1 | IS5-like element ISKpn26 family transposase | - |
| FTO26_RS27495 (FTO26_027495) | 88059..89366 | + | 1308 | Protein_101 | FepA family TonB-dependent siderophore receptor | - |
| FTO26_RS27500 (FTO26_027500) | 89428..89649 | + | 222 | WP_004213615.1 | hypothetical protein | - |
| FTO26_RS27505 (FTO26_027505) | 89792..90694 | - | 903 | WP_004213613.1 | DMT family inner membrane transporter PEG344 | - |
| FTO26_RS27510 (FTO26_027510) | 90767..91168 | - | 402 | WP_214588034.1 | LuxR C-terminal-related transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | - | iroN / rmpA / iucA / iucB / iucC / iucD / iutA / rmpA2 | 1..199279 | 199279 | |
| - | inside | IScluster/Tn | - | iroN / rmpA | 79012..98988 | 19976 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 157 a.a. Molecular weight: 17515.79 Da Isoelectric Point: 4.6155
>T214817 WP_004026354.1 NZ_CP082766:c85763-85293 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
Download Length: 471 bp
>T214817 NZ_CP110261:c65740-65453 [Escherichia albertii]
ATGACTTATACGGTAAAATTCAGGGATGATGCGCTCAAGGAATGGCTGAAACTGGATAAGACCATTCAACAACAGTTTGT
GAAAAAACTAAAAAAATGCAGCGAAAATCCTCATATACCGTCAGCAAAACTAAGAGGGCTAAAGGATTGCTACAAAATTA
AACTACGTGCATCGGGATTTCGTCTGGTTTATCAGGTGATTGACGATATGTTAATTATTGCGGTTGTTGCGGTAGGAAAA
CGAGAACGTAGTAACGTTTATAATCTCGCCAGTGAGAGAATGAGATAG
ATGACTTATACGGTAAAATTCAGGGATGATGCGCTCAAGGAATGGCTGAAACTGGATAAGACCATTCAACAACAGTTTGT
GAAAAAACTAAAAAAATGCAGCGAAAATCCTCATATACCGTCAGCAAAACTAAGAGGGCTAAAGGATTGCTACAAAATTA
AACTACGTGCATCGGGATTTCGTCTGGTTTATCAGGTGATTGACGATATGTTAATTATTGCGGTTGTTGCGGTAGGAAAA
CGAGAACGTAGTAACGTTTATAATCTCGCCAGTGAGAGAATGAGATAG
Antitoxin
Download Length: 148 a.a. Molecular weight: 16480.80 Da Isoelectric Point: 10.2498
>AT214817 WP_004026357.1 NZ_CP082766:c86203-85760 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
Download Length: 444 bp
>AT214817 NZ_CP110261:c65988-65737 [Escherichia albertii]
ATGCCTAACATCATTCTGTCTGACACCAGTGCAAGTGTCAGTGAACTGAAAAAAAATCCTATGGCTACCGTCAGTGCCGG
AGATGGTTACCCTGTCGCCATTCTTAACCGGAATCAGCCGGCATTCTACTGTGTGCCTGCTGAACTGTATGAAAGGATGC
TTGATGCTCTGGATGACCAGGAACTGGTGAAACTGGTTACTGAACGCAGCAATCAGCCACTGCATGATGTGGACCTAGAC
AGTTATTTATGA
ATGCCTAACATCATTCTGTCTGACACCAGTGCAAGTGTCAGTGAACTGAAAAAAAATCCTATGGCTACCGTCAGTGCCGG
AGATGGTTACCCTGTCGCCATTCTTAACCGGAATCAGCCGGCATTCTACTGTGTGCCTGCTGAACTGTATGAAAGGATGC
TTGATGCTCTGGATGACCAGGAACTGGTGAAACTGGTTACTGAACGCAGCAATCAGCCACTGCATGATGTGGACCTAGAC
AGTTATTTATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A663AYG0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6P1V3Q9 |